A guide to adhesion GPCR research

Research output: Contribution to journal › Journal article › Research › peer-review

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A guide to adhesion GPCR research. / Liebscher, Ines; Cevheroglu, Orkun; Hsiao, Cheng-Chih; Maia, Andre F.; Schihada, Hannes; Scholz, Nicole; Soave, Mark; Spiess, Katja; Trajkovic, Katarina; Kosloff, Mickey; Proemel, Simone.

In: FEBS Journal, Vol. 289, No. 24, 2022, p. 7610-7630.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Liebscher, I, Cevheroglu, O, Hsiao, C-C, Maia, AF, Schihada, H, Scholz, N, Soave, M, Spiess, K, Trajkovic, K, Kosloff, M & Proemel, S 2022, 'A guide to adhesion GPCR research', FEBS Journal, vol. 289, no. 24, pp. 7610-7630. https://doi.org/10.1111/febs.16258

APA

Liebscher, I., Cevheroglu, O., Hsiao, C-C., Maia, A. F., Schihada, H., Scholz, N., Soave, M., Spiess, K., Trajkovic, K., Kosloff, M., & Proemel, S. (2022). A guide to adhesion GPCR research. FEBS Journal, 289(24), 7610-7630. https://doi.org/10.1111/febs.16258

Vancouver

Liebscher I, Cevheroglu O, Hsiao C-C, Maia AF, Schihada H, Scholz N et al. A guide to adhesion GPCR research. FEBS Journal. 2022;289(24):7610-7630. https://doi.org/10.1111/febs.16258

Author

Liebscher, Ines ; Cevheroglu, Orkun ; Hsiao, Cheng-Chih ; Maia, Andre F. ; Schihada, Hannes ; Scholz, Nicole ; Soave, Mark ; Spiess, Katja ; Trajkovic, Katarina ; Kosloff, Mickey ; Proemel, Simone. / A guide to adhesion GPCR research. In: FEBS Journal. 2022 ; Vol. 289, No. 24. pp. 7610-7630.

Bibtex

@article{e1362113f5dd4d22a35cff2ea9e79d18,
title = "A guide to adhesion GPCR research",
abstract = "Adhesion G protein-coupled receptors (aGPCRs) are a class of structurally and functionally highly intriguing cell surface receptors with essential functions in health and disease. Thus, they display a vastly unexploited pharmacological potential. Our current understanding of the physiological functions and signaling mechanisms of aGPCRs form the basis for elucidating further molecular aspects. Combining these with novel tools and methodologies from different fields tailored for studying these unusual receptors yields a powerful potential for pushing aGPCR research from singular approaches toward building up an in-depth knowledge that will facilitate its translation to applied science. In this review, we summarize the state-of-the-art knowledge on aGPCRs in respect to structure-function relations, physiology, and clinical aspects, as well as the latest advances in the field. We highlight the upcoming most pressing topics in aGPCR research and identify strategies to tackle them. Furthermore, we discuss approaches how to promote, stimulate, and translate research on aGPCRs 'from bench to bedside' in the future.",
keywords = "Adhesion GPCRs, clinical application, physiology, signaling, structure-function, PROTEIN-COUPLED-RECEPTOR, NEURAL-TUBE DEFECTS, MEMORY T-CELLS, STRUCTURAL BASIS, INHIBITORY RECEPTOR, TETHERED AGONIST, GPR56 ADGRG1, ANGIOGENESIS, CD97, GENE",
author = "Ines Liebscher and Orkun Cevheroglu and Cheng-Chih Hsiao and Maia, {Andre F.} and Hannes Schihada and Nicole Scholz and Mark Soave and Katja Spiess and Katarina Trajkovic and Mickey Kosloff and Simone Proemel",
year = "2022",
doi = "10.1111/febs.16258",
language = "English",
volume = "289",
pages = "7610--7630",
journal = "F E B S Journal",
issn = "1742-464X",
publisher = "Wiley-Blackwell",
number = "24",

}

RIS

TY - JOUR

T1 - A guide to adhesion GPCR research

AU - Liebscher, Ines

AU - Cevheroglu, Orkun

AU - Hsiao, Cheng-Chih

AU - Maia, Andre F.

AU - Schihada, Hannes

AU - Scholz, Nicole

AU - Soave, Mark

AU - Spiess, Katja

AU - Trajkovic, Katarina

AU - Kosloff, Mickey

AU - Proemel, Simone

PY - 2022

Y1 - 2022

N2 - Adhesion G protein-coupled receptors (aGPCRs) are a class of structurally and functionally highly intriguing cell surface receptors with essential functions in health and disease. Thus, they display a vastly unexploited pharmacological potential. Our current understanding of the physiological functions and signaling mechanisms of aGPCRs form the basis for elucidating further molecular aspects. Combining these with novel tools and methodologies from different fields tailored for studying these unusual receptors yields a powerful potential for pushing aGPCR research from singular approaches toward building up an in-depth knowledge that will facilitate its translation to applied science. In this review, we summarize the state-of-the-art knowledge on aGPCRs in respect to structure-function relations, physiology, and clinical aspects, as well as the latest advances in the field. We highlight the upcoming most pressing topics in aGPCR research and identify strategies to tackle them. Furthermore, we discuss approaches how to promote, stimulate, and translate research on aGPCRs 'from bench to bedside' in the future.

AB - Adhesion G protein-coupled receptors (aGPCRs) are a class of structurally and functionally highly intriguing cell surface receptors with essential functions in health and disease. Thus, they display a vastly unexploited pharmacological potential. Our current understanding of the physiological functions and signaling mechanisms of aGPCRs form the basis for elucidating further molecular aspects. Combining these with novel tools and methodologies from different fields tailored for studying these unusual receptors yields a powerful potential for pushing aGPCR research from singular approaches toward building up an in-depth knowledge that will facilitate its translation to applied science. In this review, we summarize the state-of-the-art knowledge on aGPCRs in respect to structure-function relations, physiology, and clinical aspects, as well as the latest advances in the field. We highlight the upcoming most pressing topics in aGPCR research and identify strategies to tackle them. Furthermore, we discuss approaches how to promote, stimulate, and translate research on aGPCRs 'from bench to bedside' in the future.

KW - Adhesion GPCRs

KW - clinical application

KW - physiology

KW - signaling

KW - structure-function

KW - PROTEIN-COUPLED-RECEPTOR

KW - NEURAL-TUBE DEFECTS

KW - MEMORY T-CELLS

KW - STRUCTURAL BASIS

KW - INHIBITORY RECEPTOR

KW - TETHERED AGONIST

KW - GPR56 ADGRG1

KW - ANGIOGENESIS

KW - CD97

KW - GENE

U2 - 10.1111/febs.16258

DO - 10.1111/febs.16258

M3 - Journal article

C2 - 34729908

VL - 289

SP - 7610

EP - 7630

JO - F E B S Journal

JF - F E B S Journal

SN - 1742-464X

IS - 24

ER -

ID: 285713312