Thomas Mandrup-Poulsen

Thomas Mandrup-Poulsen

Professor


  1. Published

    (19)F-heptuloses as tools for the non-invasive imaging of GLUT2-expressing cells

    Malaisse, W. J., Zhang, Y., Louchami, K., Sharma, S., Dresselaers, T., Himmelreich, U., Novotny, G. W., Mandrup-Poulsen, Thomas, Waschke, D., Leshch, Y., Thimm, J., Thiem, J. & Sener, A., 2012, In: Archives of Biochemistry and Biophysics. 517, 2, p. 138-43 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    16 SKELETAL-MUSCLE LIPOPROTEIN EXPRESSION IS REGULATED BY TRAINING AND TYPE 2 DIABETES IN HUMANS AND IMPROVES INSULIN SENSITIVITY IN OBESE MICE

    Bartels, E. M., Mandrup-Poulsen, Thomas & Nielsen, L. B., Jun 2011, In: Atherosclerosis. Supplement. 12, 1, p. 4 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  3. Published

    A Blunted GPR183/Oxysterol Axis during Dysglycemia Results in Delayed Recruitment of Macrophages to the Lung during Mycobacterium tuberculosis Infection

    Ngo, M. D., Bartlett, S., Bielefeldt-Ohmann, H., Foo, C. X., Sinha, R., Arachchige, B. J., Reed, S., Mandrup-Poulsen, Thomas, Rosenkilde, Mette & Ronacher, K., 2022, In: Journal of Infectious Diseases. 225, 12, p. 2219-2228

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published
  5. Published

    A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells

    Vestergaard, A. L., Blankestijn, M., Stahl, J. L., Pallesen, E. M. H., Bang-Berthelsen, C. H., Pociot, Flemming, Novotny, G. W., Lundh, M. & Mandrup-Poulsen, Thomas, 2016, In: International Journal of Molecular Sciences (Online). 17, 6, 8 p., 896.

    Research output: Contribution to journalComment/debateResearchpeer-review

  6. Published

    A guiding map for inflammation

    Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., Hotchkiss, R., Joosten, L. A. B., Kastner, D. L., Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K. H. G., Nowak, K. L. & 12 others, O'Neill, L. A., Pickkers, P., van der Poll, T., Ridker, P. M., Schalkwijk, J., Schwartz, D. A., Siegmund, B., Steer, C. J., Tilg, H., van der Meer, J. W. M., van de Veerdonk, F. L. & Dinarello, C. A., 19 Jul 2017, In: Nature Immunology. 18, 8, p. 826-831 6 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  7. Published
  8. Published

    Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice

    Christiansen, Charlotte Bayer, Jepsen, Sara Lind, Svendsen, B., Balk-Møller, E., Dahlby, T., Kuhre, Rune Ehrenreich, Hartmann, Bolette, Mandrup-Poulsen, Thomas, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2018, In: Physiological Reports. 6, 13, p. 1-8 e13788.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

    Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, Jan 1986, In: Diabetologia. 29, 1, p. 63-7 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Age-dependent decline of beta-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study

    Barker, A., Lauria, A., Schloot, N., Hosszufalusi, N., Ludvigsson, J., Mathieu, C., Mauricio, D., Nordwall, M., Van der Schueren, B., Mandrup-Poulsen, Thomas, Scherbaum, W. A., Weets, I., Gorus, F. K., Wareham, N., Leslie, R. D. & Pozzilli, P., Mar 2014, In: Diabetes, Obesity and Metabolism. 16, 3, p. 262-267 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Age-dependent decline of β cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study

    Barker, V. A., Lauria, A., Schloot, N., Hosszufalusi, N., Ludvigsson, J., Mathieu, C. J., Mauricio, D., Nordwall, M., Van der Schueren, B., Mandrup-Poulsen, Thomas, Scherbaum, W., Weets, I., Gorus, F., Wareham, N., Leslie, R. & Pozzilli, P., 1 Oct 2013, In: Diabetes, Obesity and Metabolism Online. 16, 3, p. 262-267 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

    Lubberding, Anniek Frederike, Zhang, J., Lundh, M., Nielsen, Thomas Svava, Søndergaard, M. S., Villadsen, M., Skovhøj, E. Z., Boer, G. A., Hansen, J. B., Thomsen, Morten Bækgaard, Treebak, Jonas Thue, Holst, Jens Juul, Kanters, Jørgen K., Mandrup-Poulsen, Thomas, Jespersen, Thomas, Emanuelli, Brice & Torekov, Signe Sørensen, 2021, In: Scientific Reports. 11, 1, 14 p., 12253.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Altering β-cell number through stable alteration of miR-21 and miR-34a expression

    Backe, M. B., Novotny, G. W., Christensen, D. P., Grunnet, L. G. & Mandrup-Poulsen, Thomas, 26 Feb 2014, In: Islets. 6, 1, p. 1-8 8 p., e27754.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

    Wagner, F. F., Lundh, M., Kaya, T., McCarren, P., Zhang, Y-L., Chattopadhyay, S., Gale, J. P., Galbo, T., Fisher, S. L., Meier, B. C., Vetere, A., Richardson, S., Morgan, N. G., Christensen, D. P., Gilbert, T. J., Hooker, J. M., Leroy, M., Walpita, D., Mandrup-Poulsen, T., Wagner, B. K. & 1 others, Holson, E. B., 19 Feb 2016, In: ACS chemical biology. 11, 2, p. 363-374 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    An immune origin of type 2 diabetes?

    Kolb, H. & Mandrup-Poulsen, Thomas, 1 Jun 2005, In: Diabetologia. 48, 6, p. 1038-50 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Anti-cytokine therapies in T1D: Concepts and strategies

    Nepom, G. T., Ehlers, M. & Mandrup-Poulsen, Thomas, Dec 2013, In: Clinical Immunology. 149, 3 Part A, p. 279-85 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Anti-inflammatory properties of a novel peptide interleukin 1 receptor antagonist

    Klementiev, B., Li, S., Korshunova, Irina, Dmytriyeva, O., Pankratova, Stanislava, Walmod, P. S., Kjær, L. K., Dahllöf, M. S., Lundh, M., Christensen, D. P., Mandrup-Poulsen, Thomas, Bock, E. & Berezin, V., 2014, In: Journal of Neuroinflammation. 11, 1, p. 27

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Antitumorigenic effect of proteasome inhibitors on insulinoma cells.

    Størling, J., Allaman-Pillet, N., Karlsen, A. E., Billestrup, N., Bonny, C. & Mandrup-Poulsen, Thomas, 2004, In: Endocrinology. 146, 4, p. 1718-26 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Apolipoprotein CIII Reduces Proinflammatory Cytokine-Induced Apoptosis in Rat Pancreatic Islets via the Akt Prosurvival Pathway

    Størling, Joachim, Juntti-Berggren, L., Olivecrona, G., Prause, M. C., Berggren, P. & Mandrup-Poulsen, Thomas, 2011, In: Endocrinology. 152, 8, p. 3040-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Apolipoprotein CIII reduces proinflammatory cytokine-induced apoptosis in rat pancreatic islets via the Akt prosurvival pathway.

    Størling, Joachim, Juntti-Berggren, L., Olivecrona, G., Prause, Michala Cecilie Burstein, Berggren, P. & Mandrup-Poulsen, Thomas, Aug 2011, In: Endocrinology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Association between age, IL-10, IFN¿, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes

    Kaas, A., Pfleger, C. C., Kharagjitsingh, A. V., Schloot, N. C., Hansen, L., Buschard, K., Koeleman, B. P. C., Roep, B. O., Mortensen, H. B., Alizadeh, B. Z., Hvidoere Study Group On Childhood Diabetes, H. S. G. O. C. D. & Mandrup-Poulsen, Thomas, 2012, In: Diabetic Medicine Online. 29, 6, p. 734-741 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Association of a functional 17beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females

    Kristiansen, O. P., Nolsøe, R. L., Larsen, L., Gjesing, A. M. P., Johannesen, J., Larsen, Z. M. E., Lykkesfeldt, A. E., Karlsen, A. E., Pociot, Flemming, Mandrup-Poulsen, Thomas & DIEGG, D., 15 May 2003, In: Human Molecular Genetics. 12, 10, p. 1101-10 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission

    Schloot, N. C., Hanifi-Moghaddam, P., Aabenhus-Andersen, N., Alizadeh, B. Z., Saha, M. T., Knip, M., Devendra, D., Wilkin, T., Bonifacio, E., Roep, B. O., Kolb, H. & Mandrup-Poulsen, Thomas, 2007, In: Diabetic Medicine. 24, 5, p. 512-520 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes

    Alizadeh, B. Z., Hanifi-Moghaddam, P., Eerligh, P., van der Slik, A. R., Kolb, H., Kharagjitsingh, A. V., Pereira Arias, A. M., Ronkainen, M., Knip, M., Bonfanti, R., Bonifacio, E., Prasad, D., Wilkin, T., Giphart, M. J., Koeleman, B. P. C., Nolsøe, R., Mandrup-Poulsen, Thomas, Schloot, N. C., Roep, B. O. & DIABMARKER Study Group, D. S. G., 1 Sep 2006, In: Clinical and Experimental Immunology. 145, 3, p. 480-4 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Behandling af diabetes mellitus med biologiske laegemidler.

    Larsen, C. M. & Mandrup-Poulsen, Thomas, 2008, In: Ugeskrift for læger. 170, 24, p. 2134-7 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Beta-Cell Specific DMT1 KO Protects Islets from Cytokine Induced ROS and Apoptosis

    Hansen, J. B., Heller, S., Madsen, A. N., Holst, Birgitte, Tonnesen, M. F. & Mandrup-Poulsen, Thomas, 2012.

    Research output: Contribution to conferencePosterResearchpeer-review

  27. Published

    Blockade of Interleukin 1 in Type 1 diabetes mellitus

    Mandrup-Poulsen, Thomas, Pickersgill, L. M. S. & Donath, M. Y., 2010, In: Nature Reviews Endocrinology. 6, p. 158-166 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Calcium has a permissive role in interleukin-1beta-induced c-jun N-terminal kinase activation in insulin-secreting cells.

    Størling, J., Zaitsev, S. V., Kapelioukh, I. L., Karlsen, A. E., Billestrup, N., Berggren, P. & Mandrup-Poulsen, Thomas, 2005, In: Endocrinology. 146, 7, p. 3026-36 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study

    Kjær, L. K., Cejvanovic, V., Henriksen, T., Petersen, K. M., Hansen, Torben, Pedersen, Oluf Borbye, Christensen, C. K., Torp-Pedersen, C., Gerds, Thomas Alexander, Brandslund, I., Mandrup-Poulsen, Thomas & Poulsen, Henrik Enghusen, Dec 2017, In: Diabetes Care. 40, 12, p. 1771-1778 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published
  31. Published

    Circulating endothelial progenitor cell number in long-standing type 1 diabetic patients

    Reinhard, H., Jacobsen, P. K., Tarnov, L., Astrup, A. S., Lajer, M., Pedersen, N., Billestrup, N., Mandrup-Poulsen, Thomas, Kastrup, J., Parving, H. H. & Rossing, P., 2008, In: Diabetologia. 51, Suppl. 1, p. S531-S531

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Combination of ferric ammonium citrate with cytokines involved in apoptosis and insulin secretion of human pancreatic beta cells related to diabetes in thalassemia

    Rattanaporn, P., Tongsima, S., Mandrup-Poulsen, Thomas, Svasti, S. & Tanyong, D., 2020, In: PeerJ. 8, e9298.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.

    Ortis, F., Cardozo, A. K., Crispim, D., Störling, J., Mandrup-Poulsen, Thomas & Eizirik, D. L., 2006, In: Molecular Endocrinology. 20, 8, p. 1867-79 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Cytokines and Pancreatic β-Cell Apoptosis

    Berchtold, L. A., Prause, Michala Cecilie Burstein, Størling, Joachim & Mandrup-Poulsen, Thomas, 28 Jun 2016, Advances in Clinical Chemistry. Academic Press, Vol. 75. p. 99-158 60 p. (Advances in Clinical Chemistry, Vol. 75).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  35. Published

    Cytokines and beta-cell biology: from concept to clinical translation

    Donath, M. Y., Storling, J., Berchtold, L. A., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Endocrine Reviews. 29, 3, p. 334-50 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Cytokines and type 1 diabetes: a numbers game

    Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Diabetes. 60, 3, p. 697-9 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Cytokines cause functional and structural damage to isolated islets of Langerhans

    Mandrup-Poulsen, Thomas, Bendtzen, K., Bendixen, G., Nerup, J. & Nielsen, Jens Høiriis, Aug 1985, In: Allergy. 40, 6, p. 424-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.

    Cardozo, A. K., Ortis, F., Storling, J., Feng, Y., Rasschaert, J., Tonnesen, M., Van Eylen, F., Mandrup-Poulsen, Thomas, Herchuelz, A. & Eizirik, D. L., 2005, In: Diabetes. 54, 2, p. 452-61 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans

    Bendtzen, K., Mandrup-Poulsen, Thomas, Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, 20 Jun 1986, In: Science (New York, N.Y.). 232, 4757, p. 1545-7 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published
  41. Published
  42. Published

    DIFFERENTIAL TRANSCRIPTIONAL REGULATION OF EXTRA CELLULAR MATRIX MODULATING GENES BY PROINFLAMMATORY CYTOKINES IN INS-1 CELLS

    Hansen, J. B., Tonnesen, M. F., Friberg, J., Brunner, N. & Mandrup-Poulsen, Thomas, 2010.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  43. Published

    Defective Proinsulin Handling Modulates the MHC I Bound Peptidome and Activates the Inflammasome in β-Cells

    Khilji, Muhammad Saad, Faridi, P., Pinheiro-Machado, E., Hoefner, C., Dahlby, T., Aranha, R., Buus, Søren, Nielsen, M., Klusek, J., Mandrup-Poulsen, Thomas, Pandey, K., Purcell, A. W. & Marzec, Michal Tomasz, 2022, In: Biomedicines. 10, 4, 814.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Detrimental Actions of Chlorinated Nucleosides on the Function and Viability of Insulin-Producing Cells

    Sileikaite-Morvaközi, I., Hansen, W. H., Davies, Michael J., Mandrup-Poulsen, Thomas & Hawkins, Clare Louise, 2023, In: International Journal of Molecular Sciences. 24, 19, 13 p., 14585.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Diabetes and suppressors of cytokine signaling proteins.

    Rønn, S. G., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Diabetes. 56, 2, p. 541-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Differential transcriptional regulation of extra cellular matrix modulating genes by proinflammatory cytokines in ins-1 cells

    Hansen, J. B., Tonnesen, M., Friberg, J., Brünner, N. & Mandrup-Poulsen, Thomas, 2009. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  47. Published

    Direct demonstration of NCAM cis-dimerization and inhibitory effect of palmitoylation using the BRET2 technique

    Kulahin, N., Grunnet, L. G., Lundh, M., Christensen, D. P., Jorgensen, R., Heding, A., Billestrup, Nils, Berezin, V., Bock, E. & Mandrup-Poulsen, Thomas, 3 Jan 2011, In: FEBS Letters. 585, 1, p. 58-64 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Direct effects of cyclosporin A on human pancreatic beta-cells

    Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Sep 1986, In: Diabetes. 35, 9, p. 1049-52 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Divalent metal transporter 1 knock-down modulates il-1β mediated pancreatic beta-cell pro-apoptotic signaling pathways through the autophagic machinery

    Kang, T., Huang, H., Mandrup-Poulsen, Thomas & Larsen, M. R., 2021, In: International Journal of Molecular Sciences. 22, 15, 25 p., 8013.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic ß cell fate in response to cytokines

    Hansen, J. B., Tonnesen, M. F., Madsen, A. N., Hagedorn, P., Friberg, J., Grunnet, L. G., Heller, R. S., Nielsen, A. Ø., Størling, J., Baeyens, L., Anker-Kitai, L., Qvortrup, K., Bouwens, L., Efrat, S., Aalund, M., Andrews, N. C., Billestrup, N., Karlsen, A. E., Holst, B., Pociot, F. & 1 others, Mandrup-Poulsen, Thomas, 2012, In: Cell Metabolism. 16, 4, p. 449-61 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    ESVE-O-8 A PLACEBO-CONTROLLED STUDY ON THE EFFECT OF THE GLP-1 ANALOGUE, EXENATIDE, ON BODY COMPOSITION, LEPTIN AND ADIPONECTIN IN OBESE, CLIENTOWNED CATS

    Hølmkjær, K. M., Mandrup-Poulsen, Thomas, Nielsen, Dorte Hald, Bjørnvad, Charlotte Reinhard & Cronin, A., Sep 2015, Research Communications of the 25th ECVIM-CA Congress: ECVIM-CA Abstracts. p. 374-375 1 p.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  52. Published

    Early feeding and risk of type 1 diabetes: experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)

    Knip, M., Virtanen, S. M., Becker, D., Dupré, J., Krischer, J. P., Åkerblom, H. K., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, 2011, In: American Journal of Clinical Nutrition. 94, 6 Suppl, p. 1814S-1820S 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial

    TRIGR Study Group, T. S. G., 2018, In: J A M A: The Journal of the American Medical Association. 319, 1, p. 38-48

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets

    Hansen, B. S., Linde, S., Spinas, G. A., Welinder, B. S., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, 1988, In: Biomedica Biochimica Acta. 47, 4-5, p. 305-9 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes

    Cavelti-Weder, C., Babians-Brunner, A., Keller, C., Stahel, M. A., Kurz-Levin, M., Zayed, H., Solinger, A. M., Mandrup-Poulsen, Thomas, Dinarello, C. A. & Donath, M. Y., 2012, In: Diabetes Care.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Elevated transferrin saturation and risk of diabetes: Three population-based studies

    Ellervik, Christina, Mandrup-Poulsen, Thomas, Andersen, H. U., Tybjærg-Hansen, Anne, Frandsen, M., Birgens, H. & Nordestgaard, Børge, 2011, In: Diabetes Care. 34, 10, p. 2256-8 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling

    Ghiasi, S. M., Dahlby, T., Hede Andersen, C., Haataja, L., Petersen, S., Omar-Hmeadi, M., Yang, M., Pihl, Celina, Bresson, S. E., Khilji, Muhammad Saad, Klindt, K., Cheta, O., Perone, M. J., Tyrberg, B., Prats, C., Barg, S., Tengholm, A., Arvan, P., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, Apr 2019, In: Diabetes. 68, 4, p. 747-760 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Endothelial Progenitor Cells in Long-Standing Asymptomatic Type 1 Diabetic Patients with or without Diabetic Nephropathy

    Reinhard, H., Jacobsen, P. K., Lajer, M., Tarnow, L., Astrup, A. S., Kim, W. Y., Pedersen, N., Billestrup, Nils, Mandrup-Poulsen, Thomas, Parving, H. & Rossing, Peter, 2011, In: Nephron Clinical Practice. 118, 3, p. c309-c314 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in beta-Cells

    Dahlby, T., Simon, C., Backe, M. B., Dahllof, M. S., Holson, E., Wagner, B. K., Boni-Schnetzler, M., Marzec, Michal Tomasz, Lundh, M. & Mandrup-Poulsen, Thomas, 2020, In: International Journal of Molecular Sciences. 21, 21, 18 p., 8016.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Er der dokumentation for Lyrica til behandling af smertende diabetisk neuropati?

    Persson, F., Mogensen, C. E. & Mandrup-Poulsen, Thomas, 2005, In: Ugeskrift for læger. 167, 16, p. 1768-9; author reply 1769-70

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    European Nicotinamide Diabetes Intervention Trial (ENDIT)--sekundaerpublikation. En randomiseret, placebokontrolleret undersøgelse af intervention før debut af type 1-diabetes.

    Reimers, J. I., Larsen, C. M., Mandrup-Poulsen, Thomas & European Nicotinamide Diabetes Intervention Trial Group, E. N. D. I. T. G., 2005, In: Ugeskrift for læger. 167, 3, p. 293-6 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells

    Larsen, L., Størling, Joachim, Darville, M., Eizirik, D. L., Bonny, C., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Dec 2005, In: Diabetologia. 48, 12, p. 2582-90 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    FK506-Binding Protein 2 Participates in Proinsulin Folding

    Hoefner, C., Bryde, T. H., Pihl, C., Tiedemann, S. N., Bresson, S. E., Hotiana, H. A., Khilji, M. S., Santos, T. D., Puglia, M., Pisano, P., Majewska, M., Durzynska, J., Klindt, K., Klusek, J., Perone, M. J., Bucki, R., Hägglund, P. M., Gourdon, P. E., Gotfryd, K., Urbaniak, E. & 5 others, Borowiak, M., Wierer, M., MacDonald, P. E., Mandrup-Poulsen, Thomas & Marzec, Michal Tomasz, 2023, In: Biomolecules. 13, 1, 20 p., 152.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 diabetes

    Pham, M., Kolb, H., Battelino, T., Ludvigsson, J., Pozzilli, P., Zivehe, F., Roden, M., Mandrup-Poulsen, Thomas, Schloot, N. C. & European C-Peptide Trial, E. C. T., Jun 2013, In: Diabetologia. 56, 6, p. 1356-63 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Functional SOCS1 polymorphisms are associated with variation in obesity in whites

    Gylvin, T., Ek, J., Nolsøe, R., Albrechtsen, A., Andersen, G., Bergholdt, R., Brorsson, C., Bang-Berthelsen, C. H., Hansen, T., Karlsen, A. E., Billestrup, N., Borch-Johnsen, K., Jørgensen, T., Pedersen, Oluf Borbye, Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 2009, In: Diabetes, Obesity and Metabolism. 11, 3, p. 196-203 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia

    Nolsøe, R. L., Kelly, J. A., Pociot, Flemming, Moser, K., Kristiansen, O. P., Mandrup-Poulsen, Thomas & Harley, J. B., 1 Dec 2005, In: Genes and Immunity. 6, 8, p. 699-706 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction

    Holst, Birgitte, Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Østergaard, M. V., Hald, J., Sprinkel, A. M. E., Størling, J., Mandrup-Poulsen, Thomas, Holst, Jens Juul, Thams, P., Orskov, C., Wierup, N., Sundler, F., Madsen, O. D. & Schwartz, Thue W., 2009, In: Endocrinology. 150, 6, p. 2577-85 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During Mycobacterium tuberculosis Infection and Is Associated With TB Disease Severity

    Bartlett, S., Gemiarto, A. T., Ngo, M. D., Sajiir, H., Hailu, S., Sinha, R., Foo, C. X., Kleynhans, L., Tshivhula, H., Webber, T., Bielefeldt-Ohmann, H., West, N. P., Hiemstra, A. M., MacDonald, C. E., Christensen, Liv von Voss, Schlesinger, L. S., Walzl, G., Rosenkilde, Mette, Mandrup-Poulsen, Thomas & Ronacher, K., 2020, In: Frontiers in Immunology. 11, 11 p., 601534.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Accepted/In press

    Genetic deficiency of tissue inhibitor of metalloproteinase (TIMP) 1 does not affect apoptosis in cytokine-exposed mouse islets in vitro.

    Hansen, J. B., Tonnesen, M. F., Rømer, M. U. K., Billestrup, Nils, Brunner, N. & Mandrup-Poulsen, Thomas, 2010, (Accepted/In press).

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  70. Published

    Glucolipotoxic conditions induce beta-cell iron import, cytosolic ROS formation and apoptosis

    Hansen, J. B., Dos Santos, L. R. B., Liu, Y., Prentice, K. J., Teudt, F., Tonnesen, M., Jonas, J., Wheeler, M. B. & Mandrup-Poulsen, Thomas, 2018, In: Journal of Molecular Endocrinology. 61, 2, p. 69-77

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

    Maedler, K., Størling, J., Sturis, J., Zuellig, R. A., Spinas, G. A., Arkhammar, P. O. G., Mandrup-Poulsen, Thomas & Donath, M. Y., 2004, In: Diabetes. 53, 7, p. 1706-13 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Glutaminsyre-decarboxylase-antistoffer og diabetes.

    Mandrup-Poulsen, Thomas, 2007, In: Ugeskrift for læger. 169, 4, p. 300-4 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Gluten under graviditeten og risiko for type 1 diabetes hos barnet: [Medicinsk nyhed]

    Mandrup-Poulsen, Thomas, 2019, In: Ugeskrift for Laeger. 22

    Research output: Contribution to journalComment/debateCommunication

  74. Published

    Granzyme A in the Pathogenesis of Type 1 Diabetes: The Yes and the No

    Mandrup-Poulsen, Thomas, Dec 2017, In: Diabetes. 66, 12, p. 2937-2939 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  75. Published

    Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

    Larsen, C. M., Døssing, M. G., Papa, S., Franzoso, G., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 May 2006, In: Diabetologia. 49, 5, p. 980-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Growth differences between North American and European children at risk for type 1 diabetes

    Nucci, A. M., Becker, D. J., Virtanen, S. M., Cuthbertson, D., Softness, B., Huot, C., Wasikowa, R., Dosch, H. M., Akerblom, H. K., Knip, M., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, Aug 2012, In: Pediatric Diabetes Online. 13, 5, p. 425-31 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    HDAC Inhibitor-Mediated Beta-Cell Protection Against Cytokine-Induced Toxicity Is STAT1 Tyr701 Phosphorylation Independent

    Dahllöf, M. S., Christensen, D. P., Harving, M., Wagner, B. K., Mandrup-Poulsen, Thomas & Lundh, M., 13 Jan 2015, In: Journal of Interferon & Cytokine Research. 35, 1, p. 63-70 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    HDAC3 inhibition rescues pancreatic beta cells from glucolipotoxicity and improves insulin secretion in obese diabetic rats

    Lundh, M., Galbo, T., Wagner, F. F., Christensen, D. P., Walpita, D., Gale, J. P., Zhang, Y., Hooker, J., Shulman, G. I., Mandrup-Poulsen, Thomas, Holson, E. B. & Wagner, B. K., Sep 2013, In: Diabetologia. 56, 1 suppl, p. S219-S219

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression

    Fred, R. G., Bang-Berthelsen, C. H., Mandrup-Poulsen, Thomas, Grunnet, L. G. & Welsh, N., 2010, In: PLoS ONE. 5, 5, p. e10843

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus

    Christensen, D. P., Dahllöf, M. S., Lundh, M., Rasmussen, D. N., Nielsen, M. D., Billestrup, Nils, Grunnet, L. G. & Mandrup-Poulsen, Thomas, 2011, In: Molecular Medicine. 17, 5-6, p. 378-90 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats

    Lundh, M., Galbo, T., Poulsen, Steen Seier & Mandrup-Poulsen, Thomas, Jul 2015, In: Diabetes, Obesity and Metabolism. 17, 7, p. 703-7 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  82. Published

    Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

    Lundh, M., Christensen, D. P., Damgaard Nielsen, M., Richardson, S. J., Dahllöf, M. S., Skovgaard, T., Berthelsen, J., Dinarello, C. A., Stevenazzi, A., Mascagni, P., Grunnet, Louise Groth, Morgan, N. G. & Mandrup-Poulsen, Thomas, 2012, In: Diabetologia. 55, 9, p. 2421-31

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Hydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial

    Knip, M., Åkerblom, H. K., Becker, D., Dosch, H., Dupre, J., Fraser, W., Howard, N., Ilonen, J., Krischer, J. P., Kordonouri, O., Lawson, M. L., Palmer, J. P., Savilahti, E., Vaarala, O., Virtanen, S. M., TRIGR Study Group, T. S. G. & Mandrup-Poulsen, Thomas, 11 Jun 2014, In: JAMA : the journal of the American Medical Association. 311, 22, p. 2279-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    IAPP boosts islet macrophage IL-1 in type 2 diabetes

    Mandrup-Poulsen, Thomas, 1 Oct 2010, In: Nature Immunology. 11, 10, p. 881-3 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    IL-1 beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

    Jacobsen, M. L. B., Ronn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2009, In: Diabetologia. 52, 2, p. 281-288 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    IL-1 family nomenclature

    Dinarello, C., Arend, W., Sims, J., Smith, D., Blumberg, H., O'Neill, L., Goldbach-Mansky, R., Pizarro, T., Hoffman, H., Bufler, P., Nold, M., Ghezzi, P., Mantovani, A., Garlanda, C., Boraschi, D., Rubartelli, A., Netea, M., van der Meer, J., Joosten, L., Mandrup-Poulsen, T. & 14 others, Donath, M., Lewis, E., Pfeilschifter, J., Martin, M., Kracht, M., Muehl, H., Novick, D., Lukic, M., Conti, B., Solinger, A., Kelk, P., Peyman, K., van de Veerdonk, F. & Gabel, C., 1 Nov 2010, In: Nature Immunology. 11, 11, p. 973 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    IL-1 receptor antagonism and muscle gene expression in patients with type 2 diabetes

    Berchtold, L. A., Larsen, C. M., Vaag, Allan, Faulenbach, M., Workman, C. T., Kruhøffer, M., Donath, M. & Mandrup-Poulsen, Thomas, 2009, In: European Cytokine Network. 20, 2, p. 81-87 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    IL-1β-induced pro-apoptotic signaling is facilitated by NCAM/FGF receptor signaling and inhibited by the C3d ligand in the INS-1E rat beta cell line

    Petersen, L. G., Størling, J., Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, N., Bock, E. M. & Mandrup-Poulsen, Thomas, 2006, In: Diabetologia. 49, p. 1864-75

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    IL-1beta-induced chemokine and Fas expression are inhibited by suppressor of cytokine signalling-3 in insulin-producing cells

    Jacobsen, M. L. B., Rønn, S. G., Bruun, C., Larsen, C. M., Eizirik, D. L., Mandrup-Poulsen, Thomas & Billestrup, Nils, 2008, In: Diabetologia. 52, 2, p. 281-8 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line

    Petersen, L. G., Størling, Joachim, Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, Nils, Bock, E. & Mandrup-Poulsen, Thomas, 2006, In: Diabetologia. 49, 8, p. 1864-75 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Identification of a type 1 diabetes-associated CD4 promoter haplotype with high constitutive activity

    Kristiansen, O. P., Karlsen, A. E., Larsen, Z. M., Johannesen, Jesper, Pociot, Flemming, Mandrup-Poulsen, Thomas & Danish IDDM Epidemiology and Genetics Group and Danish Study Group of IDDM in Childhood, D. I. E. A. G. G. A. D. S. G. O. I. I. C., 1 Jun 2004, In: Scandinavian Journal of Immunology. 59, 6, p. 582-91 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Immunometabolism in 2017: Metabolism and the inflammasome in health and ageing

    Mandrup-Poulsen, Thomas, Feb 2018, In: Nature Reviews Endocrinology. 14, 2, p. 72-74 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Increased Plasma Ferritin Concentration and Low-Grade Inflammation-A Mendelian Randomization Study

    Moen, I. W., Bergholdt, H. K. M., Mandrup-Poulsen, Thomas, Nordestgaard, Børge & Ellervik, Christina, 2018, In: Clinical Chemistry. 64, 2, p. 374-385 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J Mice

    Fjære, E., Aune, U. L., Røen, K., Keenan, A. H., Ma, Tao, Borkowski, K., Kristensen, D. M. B., Novotny, G. W., Mandrup-Poulsen, Thomas, Hudson, B. D., Milligan, G., Xi, Y., Newman, J. W., Haj, F. G., Liaset, B., Kristiansen, Karsten & Madsen, L., 2014, In: The Journal of Biological Chemistry. 289, 23, p. 16032-16045 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Inflammatory and metabolic stress perturbs the beta cell circadian clock: [Meeting Abstract]

    Andersen, Phillip Alexander Keller, Rose, P. H., Koomen, M., Petrenko, V., Dahlby, T., Ghiasi, S. M., Dibner, C. & Mandrup-Poulsen, Thomas, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S120-S120 237.

    Research output: Contribution to journalConference abstract in journalResearch

  96. Published

    Inhibition of Nuclear Factor-kappa B or Bax Prevents Endoplasmic Reticulum Stress-But Not Nitric Oxide-Mediated Apoptosis in INS-1E Cells

    Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Storling, J. & Mandrup-Poulsen, Thomas, 2009, In: Endocrinology. 150, 9, p. 4094-4103 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Inhibition of beta cell growth and function by bone morphogenetic proteins

    Bruun, C., Christensen, G. L., Jacobsen, M. L. B., Kanstrup, M. B., Jensen, P. R., Fjordvang, H., Mandrup-Poulsen, Thomas & Billestrup, Nils, 27 Sep 2014, In: Diabetologia. 57, 12, p. 2546-54 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

    Larsen, L., Tonnesen, M., Ronn, S. G., Størling, Joachim, Jørgensen, S., Mascagni, P., Dinarello, C. A., Billestrup, Nils & Mandrup-Poulsen, Thomas, Apr 2007, In: Diabetologia. 50, 4, p. 779-89 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

    Larsen, L., Tonnesen, M. F., Ronn, S. G., Storling, J., Jørgensen, S., Mascagni, P., Dinarello, C. A., Billestrup, N. & Mandrup-Poulsen, Thomas, 2007, In: Diabetologia. 50, 4, p. 779-789 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells

    Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, Nils, Eizirik, D. L., Størling, Joachim & Mandrup-Poulsen, Thomas, Sep 2009, In: Endocrinology. 150, 9, p. 4094-103 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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