Nils Billestrup

Nils Billestrup

Professor

Member of:

    ORCID: 0000-0002-4968-8067

    Publication year:
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    51 - 100 out of 118Page size: 50
    1. 2008
    2. Published

      Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

      Rønn, S. G., Börjesson, A., Bruun, C., Heding, P. E., Frobøse, H., Mandrup-Poulsen, Thomas, Karlsen, A. E., Rasschaert, J., Sandler, S. & Billestrup, Nils, 2008, In: Diabetologia. 51, 10, p. 1873-1882 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2007
    4. Published

      Inhibition of histone deacetylases prevents cytokine-induced toxicity in beta cells

      Larsen, L., Tonnesen, M., Ronn, S. G., Størling, Joachim, Jørgensen, S., Mascagni, P., Dinarello, C. A., Billestrup, Nils & Mandrup-Poulsen, Thomas, Apr 2007, In: Diabetologia. 50, 4, p. 779-89 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Effects of growth hormone on glucose and fat metabolism in human subjects

      Jørgensen, J. O. L., Møller, L., Krag, M. B., Billestrup, Nils & Christiansen, J. K. S., 1 Mar 2007, In: Endocrinology & Metabolism Clinics of North America. 36, 1, p. 75-87 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. 2006
    7. Published

      GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus

      Jørgensen, J. O. L., Jessen, N., Pedersen, S. B., Vestergaard, E. T., Gormsen, L. C., Lund, S. & Billestrup, Nils, 1 Nov 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 5, p. E899-905

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

      Larsen, C. M., Døssing, M. G., Papa, S., Franzoso, G., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 May 2006, In: Diabetologia. 49, 5, p. 980-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      IL-1beta-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line

      Petersen, L. G., Størling, Joachim, Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, Nils, Bock, E. & Mandrup-Poulsen, Thomas, 2006, In: Diabetologia. 49, 8, p. 1864-75 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. 2005
    11. Published

      Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells

      Larsen, L., Størling, Joachim, Darville, M., Eizirik, D. L., Bonny, C., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Dec 2005, In: Diabetologia. 48, 12, p. 2582-90 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt

      Størling, Joachim, Binzer, J., Andersson, A., Züllig, R. A., Tonnesen, M., Knudsen, R. L. P., Spinas, G. A., Sandler, S., Billestrup, Nils & Mandrup-Poulsen, Thomas, 1 Oct 2005, In: Diabetologia. 48, 10, p. 2039-50 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Regulation of pancreatic beta-cell mass and proliferation by SOCS-3

      Lindberg, K., Rønn, S. G., Tornehave, D., Richter, H., Hansen, J. A., Rømer, J., Jackerott, M. & Billestrup, Nils, Oct 2005, In: Journal of Molecular Endocrinology. 35, 2, p. 231-43 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling

      Lund, I. K., Hansen, J. A., Andersen, H. S., Møller, N. P. H. & Billestrup, Nils, 1 Apr 2005, In: Journal of Molecular Endocrinology. 34, 2, p. 339-51 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. 2004
    16. Published

      Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways

      Karlsen, A. E., Heding, P. E., Frobøse, H., Rønn, S. G., Kruhøffer, M., Orntoft, T. F., Darville, M., Eizirik, D. L., Pociot, Flemming, Nerup, J., Mandrup-Poulsen, Thomas & Billestrup, Nils, 1 Nov 2004, In: Diabetologia. 47, 11, p. 1998-2011 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

      Gylvin, T., Nolsøe, R., Hansen, Torben, Nielsen, E. M. D., Bergholdt, R., Karlsen, A. E., Billestrup, Nils, Borch-Johnsen, K., Pedersen, O., Mandrup-Poulsen, Thomas, Nerup, J. & Pociot, Flemming, 1 Jul 2004, In: Diabetologia. 47, 7, p. 1273-7 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Growth hormone receptor expression and function in pituitary adenomas

      Clausen, L. R., Kristiansen, M. T., Rasmussen, L. M., Billestrup, Nils, Blaabjerg, O., Ledet, T. & Jørgensen, J. O. L., May 2004, In: Clinical Endocrinology. 60, 5, p. 576-83 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. 2003
    20. Published

      Nuclear translocation and retention of growth hormone

      Mertani, H. C., Raccurt, M., Abbate, A., Kindblom, J., Törnell, J., Billestrup, Nils, Usson, Y., Morel, G. & Lobie, P. E., Jul 2003, In: Endocrinology. 144, 7, p. 3182-95 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells

      Friedrichsen, B. N., Richter, H. E., Hansen, J. A., Rhodes, C. J., Nielsen, Jens Høiriis, Billestrup, Nils & Møldrup, A., May 2003, In: Molecular endocrinology (Baltimore, Md.). 17, 5, p. 945-58 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      The role of signal transducer and activator of transcription 5 in the inhibitory effects of GH on adipocyte differentiation

      Richter, H. E., Albrektsen, T. & Billestrup, Nils, Apr 2003, In: Journal of Molecular Endocrinology. 30, 2, p. 139-50 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      SOCS-3 is involved in the downregulation of the acute insulin-like effects of growth hormone in rat adipocytes by inhibition of Jak2/IRS-1 signaling

      Ridderstråle, M., Amstrup, J., Hilton, D. J., Billestrup, Nils & Tornqvist, H., Mar 2003, In: Hormone and Metabolic Research. Supplement. 35, 3, p. 169-77 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. 2002
    25. Published

      Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling

      Greenhalgh, C. J., Metcalf, D., Thaus, A. L., Corbin, J. E., Uren, R., Morgan, P. O., Fabri, L. J., Zhang, J., Martin, H. M., Willson, T. A., Billestrup, Nils, Nicola, N. A., Baca, M., Alexander, W. S. & Hilton, D. J., 25 Oct 2002, In: The Journal of Biological Chemistry. 277, 43, p. 40181-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells

      Rønn, S. G., Hansen, J. A., Lindberg, K., Karlsen, A. E. & Billestrup, Nils, Sep 2002, In: Molecular endocrinology (Baltimore, Md.). 16, 9, p. 2124-34 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. 2000
    28. Published

      Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B

      Stofega, M. R., Herrington, J., Billestrup, Nils & Carter-Su, C., Sep 2000, In: Molecular endocrinology (Baltimore, Md.). 14, 9, p. 1338-50 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation

      Behncken, S. N., Billestrup, Nils, Brown, R., Amstrup, J., Conway-Campbell, B. & Waters, M. J., 2 Jun 2000, In: The Journal of Biological Chemistry. 275, 22, p. 17000-7 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. 1999
    31. Published

      Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins

      Hansen, J. A., Lindberg, K., Hilton, D. J., Nielsen, Jens Høiriis & Billestrup, Nils, Nov 1999, In: Molecular endocrinology (Baltimore, Md.). 13, 11, p. 1832-43 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Developmental expression of proprotein convertase 1/3 in the rat

      Lee, Y. C., Damholt, A. B., Billestrup, Nils, Kisbye, T., Galante, P., Michelsen, B., Kofod, H. & Nielsen, Jens Høiriis, 10 Sep 1999, In: Molecular and Cellular Endocrinology. 155, 1-2, p. 27-35 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Beta cell proliferation and growth factors

      Nielsen, Jens Høiriis, Svensson, C., Møldrup, A., Galsgaard, E. D. & Billestrup, Nils, Jan 1999, In: Journal of Molecular Medicine. 77, 1, p. 62-6 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. 1998
    35. Published

      Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation

      Hansen, L. H., Madsen, B., Teisner, B., Nielsen, Jens Høiriis & Billestrup, Nils, Aug 1998, In: Molecular endocrinology (Baltimore, Md.). 12, 8, p. 1140-9 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Molecular mechanism of growth hormone signalling

      Billestrup, Nils, Hansen, J. A., Hansen, L. H., Møldrup, A., Galsgaard, E. D. & Nielsen, Jens Høiriis, Apr 1998, In: Endocrine Journal. 45 Suppl, p. S41-5

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Regulation of glucose transport and c-fos and egr-1 expression in cells with mutated or endogenous growth hormone receptors

      Gong, T. W., Meyer, D. J., Liao, J., Hodge, C. L., Campbell, G. S., Wang, X., Billestrup, Nils, Carter-Su, C. & Schwartz, J., Apr 1998, In: Endocrinology. 139, 4, p. 1863-71 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

      Adams, T. E., Hansen, J. A., Starr, R., Nicola, N. A., Hilton, D. J. & Billestrup, Nils, 16 Jan 1998, In: The Journal of Biological Chemistry. 273, 3, p. 1285-7 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. 1997
    40. Published

      Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas

      Carlsson, C., Tornehave, D., Lindberg, K., Galante, P., Billestrup, Nils, Michelsen, B., Larsson, L. I. & Nielsen, Jens Høiriis, Sep 1997, In: Endocrinology. 138, 9, p. 3940-8 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      The role of GH receptor tyrosine phosphorylation in Stat5 activation

      Hansen, J. A., Hansen, Lars Hestbjerg, Wang, X., Kopchick, J. J., Gouilleux, F., Groner, B., Møldrup, A., Galsgaard, E. D., Nielsen, Jens Høiriis & Billestrup, Nils, Jun 1997, In: Journal of Molecular Endocrinology. 18, 3, p. 213-21 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. 1996
    43. Published

      Growth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling

      Argetsinger, L. S., Norstedt, G., Billestrup, Nils, White, M. F. & Carter-Su, C., 15 Nov 1996, In: The Journal of Biological Chemistry. 271, 46, p. 29415-21 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Distinct cytoplasmic domains of the growth hormone receptor are required for glucocorticoid- and phorbol ester-induced decreases in growth hormone (GH) binding. These domains are different from that reported for GH-induced receptor internalization

      King, A. P., Tseng, M. J., Logsdon, C. D., Billestrup, Nils & Carter-Su, C., 26 Jul 1996, In: The Journal of Biological Chemistry. 271, 30, p. 18088-94 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene

      Galsgaard, E. D., Gouilleux, F., Groner, B., Serup, Palle, Billestrup, Nils & Nielsen, Jens Høiriis, Jun 1996, In: Molecular endocrinology (Baltimore, Md.). 10, 6, p. 652-60 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation

      Hansen, L. H., Wang, X., Kopchick, J. J., Bouchelouche, P., Galsgaard, E. D., Nielsen, Jens Høiriis & Billestrup, Nils, 24 May 1996, In: The Journal of Biological Chemistry. 271, 21, p. 12669-73 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH

      Smit, L. S., Meyer, D. J., Billestrup, Nils, Norstedt, G., Schwartz, J. & Carter-Su, C., May 1996, In: Molecular endocrinology (Baltimore, Md.). 10, 5, p. 519-33 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. 1995
    49. Published

      Growth hormone-dependent phosphorylation of tyrosine 333 and/or 338 of the growth hormone receptor

      VanderKuur, J. A., Wang, X., Zhang, L., Allevato, G., Billestrup, Nils & Carter-Su, C., 15 Sep 1995, In: The Journal of Biological Chemistry. 270, 37, p. 21738-44 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Requirement of tyrosine residues 333 and 338 of the growth hormone (GH) receptor for selected GH-stimulated function

      Lobie, P. E., Allevato, G., Norstedt, G., Billestrup, Nils & Nielsen, Jens Høiriis, 15 Sep 1995, In: The Journal of Biological Chemistry. 270, 37, p. 21745-50 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Molecular dissection of the growth hormone receptor. Identification of distinct cytoplasmic domains corresponding to different signaling pathways

      Billestrup, Nils, Allevato, G., Møldrup, A., Galsgaard, E. D., Amstrup, J., Hansen, J. A., Svensson, C. & Nielsen, Jens Høiriis, 7 Sep 1995, In: Annals of the New York Academy of Sciences. 766, p. 481-3 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation

      Allevato, G., Billestrup, Nils, Goujon, L., Galsgaard, E. D., Norstedt, G., Postel-Vinay, M. C., Kelly, P. A. & Nielsen, Jens Høiriis, 21 Jul 1995, In: The Journal of Biological Chemistry. 270, 29, p. 17210-4 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1

      Argetsinger, L. S., Hsu, G. W., Myers, M. G., Billestrup, Nils, White, M. F. & Carter-Su, C., 16 Jun 1995, In: The Journal of Biological Chemistry. 270, 24, p. 14685-92 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

      VanderKuur, J., Allevato, G., Billestrup, Nils, Norstedt, G. & Carter-Su, C., 31 Mar 1995, In: The Journal of Biological Chemistry. 270, 13, p. 7587-93 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription

      Billestrup, Nils, Bouchelouche, P., Allevato, G., Ilondo, M. & Nielsen, Jens Høiriis, 28 Mar 1995, In: Proceedings of the National Academy of Sciences of the United States of America. 92, 7, p. 2725-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. 1994
    57. Published

      The cellular mechanism of growth hormone signal transduction

      Lobie, P. E., Wood, T. J., Sliva, D., Billestrup, Nils, Waters, M. J., Enberg, B. & Norstedt, G., Dec 1994, In: Acta Paediatrica. Supplement. 406, p. 39-46; discussion 47

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Published

      Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase

      VanderKuur, J. A., Wang, X., Zhang, L., Campbell, G. S., Allevato, G., Billestrup, Nils, Norstedt, G. & Carter-Su, C., 26 Aug 1994, In: The Journal of Biological Chemistry. 269, 34, p. 21709-17 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Cell transfection as a tool to study growth hormone action

      Norstedt, G., Enberg, B., Francis, S., Hansson, A., Hulthén, A., Lobie, P. E., Sliva, D., Wood, T. J. & Billestrup, Nils, Jul 1994, In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 206, 3, p. 181-4 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Published

      Identification of intracellular domains in the growth hormone receptor involved in signal transduction

      Billestrup, Nils, Allevato, G., Norstedt, G., Møldrup, A. & Nielsen, Jens Høiriis, Jul 1994, In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 206, 3, p. 205-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. 1993
    62. Published

      Growth of the endocrine pancreas: the role of somatolactogenic hormones and receptors

      Billestrup, Nils, Møldrup, A., Allevato, G., Petersen, Erik Brinch, Pedersen, Johan, Hansen, J. A. & Nielsen, Jens Høiriis, Feb 1993, In: Biochemical Society Transactions. 21, 1, p. 146-9 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. 1992
    64. Published

      Pituitary adenomas in mice transgenic for growth hormone-releasing hormone

      Asa, S. L., Kovacs, K., Stefaneanu, L., Horvath, E., Billestrup, Nils, Gonzalez-Manchon, C. & Vale, W., Nov 1992, In: Endocrinology. 131, 5, p. 2083-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. Published

      Evidence for association of the cloned liver growth hormone receptor with a tyrosine kinase

      Wang, X., Uhler, M. D., Billestrup, Nils, Norstedt, G., Talamantes, F., Nielsen, Jens Høiriis & Carter-Su, C., 25 Aug 1992, In: The Journal of Biological Chemistry. 267, 24, p. 17390-6 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Published

      The role of growth hormone and prolactin in beta cell growth and regeneration

      Nielsen, Jens Høiriis, Møldrup, A., Billestrup, Nils, Petersen, E. D., Allevato, G. & Stahl, M., 1992, Pancreatic islet cell regeneration and growth. Vol. 321. p. 9-17; discussion 19-20 (Advances in Experimental Medicine and Biology).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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