Sam Trammell
Special Consultant, Guest Researcher
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
Moritz Group
Blegdamsvej 3B, Mærsk Tårnet, 8. sal
2200 København N.
- 2024
- Published
Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function
Zhang, Q., Li, Z., Li, Q., Trammell, Sam, Schmidt, M. S., Pires, K. M., Cai, J., Zhang, Y., Kenny, H., Boudina, S., Brenner, C. & Abel, E. D., 2024, In: EMBO Journal. 43, 3, p. 362-390Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans
Peluso, A. A., Lundgaard, A. T., Babaei, P., Mousovich-Neto, F., Rocha, A. L., Damgaard, M. V., Bak, E. G., Gnanasekaran, T., Dollerup, O. L., Trammell, S. A. J., Nielsen, T. S., Kern, T., Abild, C. B., Sulek, K., Ma, T., Gerhart-Hines, Z., Gillum, M. P., Arumugam, M., Ørskov, C., McCloskey, D. & 4 others, , 2023, In: npj Aging. 9, 21 p., 7.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Clostridium scindens secretome suppresses virulence gene expression of Clostridioides difficile in a bile acid-independent manner
Saenz, C., Fang, Q., Gnanasekaran, Thiyagarajan, Trammell, Sam, Buijink, Jesse A., Pisano, P., Wierer, M., Moens, F., Lengger, B., Brejnrod, A. & Arumugam, Mani, 2023, In: Microbiology Spectrum. 11, 5, p. 1-18 e0393322.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of bile acid-CoA:amino acid N-acyltransferase as the hepatic N-acyl taurine synthase for polyunsaturated fatty acids
Trammell, Sam, Gamon, Luke Francis, Gotfryd, K., Michler, Katja Thorøe, Alrehaili, B. D., Rix, I., Knop, Filip Krag, Gourdon, Pontus Emanuel, Lee, Y. K., Davies, Michael J., Gillum, M. P. & Grevengoed, Trisha Jean, 2023, In: Journal of Lipid Research. 64, 9, 9 p., 100361.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice
Alrehaili, B. D., Lee, M., Takahashi, S., Novak, R., Rimal, B., Boehme, S., Trammell, Sam, Grevengoed, Trisha Jean, Kumar, D., Alnouti, Y., Chiti, K., Wang, X., Patterson, A. D., Chiang, J. Y. L., Gonzalez, F. J. & Lee, Y., 2022, In: Hepatology Communications. 6, 10, p. 2765-2780 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells
Elmelund, E., Galsgaard, Katrine Douglas, Johansen, C. D., Trammell, Sam, Billeschou, Anna, Winther-Sørensen, Marie, Dal, Jenna Elizabeth Hunt, Sorensen, Charlotte Mehlin, Kruse, Thomas, Lau, J. F., Grevengoed, Trisha Jean, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: iScience. 25, 11, 20 p., 105296.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit
Flippo, K. H., Trammell, Sam, Gillum, M. P., Aklan, I., Perez, M. B., Yavuz, Y., Smith, N. K., Jensen-Cody, S. O., Zhou, B., Claflin, K. E., Beierschmitt, A., Fink-Jensen, Anders, Knop, Filip Krag, Palmour, R. M., Grueter, B. A., Atasoy, D. & Potthoff, M. J., 2022, In: Cell Metabolism. 34, 2, p. 317-328.e6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Opposing roles of the entero-pancreatic hormone urocortin-3 in glucose metabolism in rats
Grunddal, Kaare Villum, Trammell, Sam, Bæch-Laursen, C., Andersen, Daniel Bjørklund, Xu, S. F. S., Andersen, H., Gillum, M. P., Ghiasi, S. M., Novak, Ivana, Tyrberg, B., Li, C., Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul & Kuhre, Rune Ehrenreich, 2022, In: Diabetologia. 65, p. 1018–1031Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fibroblast growth factor 21 is the main alcohol responsive peptide hormone in humans and individuals with alcohol use disorder exihibit increased plasma concentrations after alcohol intake
Lanng, A., Gasbjerg, Lærke Smidt, Sucksdorff, A., Svenningsen, J., Trammell, Sam, Vilsbøll, Tina, Gillum, M. & Knop, Filip Krag, 2022, In: Journal of Hepatology. 77, S1, p. S121-S121 1 p., THU006.Research output: Contribution to journal › Conference abstract in journal › Research
- 2021
- Published
Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes
Dall, M., Hassing, Anna Skab, Niu, Lili, Nielsen, Thomas Svava, Ingerslev, L. R., Sulek, K., Trammell, Sam, Gillum, M. P., Barrès, Romain, Larsen, Steen, Poulsen, Steen Seier, Mann, Matthias, Ørskov, Cathrine & Treebak, Jonas Thue, 2021, In: Journal of Biological Chemistry. 297, 6, 26 p., 101388.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An abundant biliary fatty acid metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides
Grevengoed, Trisha Jean, Trammell, Sam, Svenningsen, J. S., Makarov, M., Nielsen, Thomas Svava, Jacobsen, Jens Christian Brings, Calder, P. C., Migaud, M. E., Cravatt, B. & Gillum, M. P., 2021, In: Journal of Clinical Investigation. 131, 6, 12 p., e143861.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Biochemical Pathways of Nicotinamide-Derived Pyridones
Hayat, F., Sonavane, M., Makarov, M. V., Trammell, Sam, McPherson, P., Gassman, N. R. & Migaud, M. E., 2021, In: International Journal of Molecular Sciences. 22, 3, 28 p., 1145.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy
Eiken, A., Fuglsang, S., Eiken, M., Svane, M. S., Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hansen, S. H., Trammell, Sam, Svenningsen, J. S., Rehfeld, Jens Frederik, Bojsen-Møller, K. N., Jørgensen, N. B., Holst, Jens Juul, Madsbad, Sten, Madsen, J. L. & Dirkse, C., 2020, In: International Journal of Obesity. 44, p. 1872-1883Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Coronavirus infection and PARP expression dysregulate the NAD metabolome: An actionable component of innate immunity
Heer, C. D., Sanderson, D. J., Voth, L. S., Alhammad, Y. M. O., Schmidt, M. S., Trammell, Sam, Perlman, S., Cohen, M. S., Fehr, A. R. & Brenner, C., 2020, In: Journal of Biological Chemistry. 295, 52, p. 17986-17996 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5
Trammell, Sam, Svenningsen, J. S., Holst, Jens Juul, Gillum, M. P. & Kuhre, Rune Ehrenreich, 2020, In: Molecules. 25, 14 p., 2371.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis
Winther-Sørensen, M., Galsgaard, K. D., Santos, A., Trammell, S. A. J., Sulek, K., Kuhre, R. E., Pedersen, J., Andersen, D. B., Hassing, A. S., Dall, M., Treebak, J. T., Gillum, M. P., Torekov, S. S., Windeløv, J. A., Hunt, J. E., Kjeldsen, S. A. S., Jepsen, S. L., Vasilopoulou, C. G., Knop, F. K., Ørskov, C. & 7 others, , 2020, In: Molecular Metabolism. 42, 18 p., 101080.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fasting- and ghrelin-induced food intake is regulated by NAMPT in the hypothalamus
de Guia, R. M., Hassing, Anna Skab, Skov, Louise Julie, Ratner, C., Plucinska, Kaja, Madsen, S., Diep, T. A., dela Cruz, Gelo, Trammell, Sam, Sustarsic, E. G., Emanuelli, Brice, Gillum, M. P., Gerhart-Hines, Zach, Holst, Birgitte & Treebak, Jonas Thue, 2020, In: Acta Physiologica. 228, 4Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
Christiansen, Charlotte Bayer, Trammell, Sam, Albrechtsen, Nicolai Jacob Wewer, Schoonjans, K., Albrechtsen, Reidar, Gillum, M. P., Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G574-G584 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity
Dall, M., Trammell, Sam, Asping, M., Hassing, Anna Skab, Agerholm, M., Vienberg, S. G., Gillum, M. P., Larsen, Steen & Treebak, Jonas Thue, 2019, In: The Journal of Biological Chemistry. 294, 36, p. 13304-13326 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity
Dollerup, O. L., Trammell, Sam, Hartmann, Bolette, Holst, Jens Juul, Christensen, B., Møller, N., Gillum, M. P., Treebak, Jonas Thue & Jessen, N., 1 Nov 2019, In: The Journal of clinical endocrinology and metabolism. 104, 11, p. 5703-5714 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis
Grevengoed, Trisha Jean, Trammell, Sam, McKinney, M. K., Petersen, N., Cardone, R. L., Svenningsen, J. S., Ogasawara, D., Nexøe-Larsen, C. C., Knop, Filip Krag, Schwartz, Thue W., Kibbey, R. G., Cravatt, B. F. & Gillum, M. P., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24770-24778Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The chemistry of the vitamin B3 metabolome
Makarov, M. V., Trammell, Sam & Migaud, M. E., 2019, In: Biochemical Society Transactions. 47, 1, p. 131-147Research output: Contribution to journal › Review › Research › peer-review
- 2018
Nicotinamide riboside preserves cardiac function in a mouse model of dilated cardiomyopathy
Diguet, N., Trammell, Sam, Tannous, C., Deloux, R., Piquereau, J., Mougenot, N., Gouge, A., Gressette, M., Manoury, B., Blanc, J., Breton, M., Decaux, J. F., Lavery, G. G., Baczkó, I., Zoll, J., Garnier, A., Li, Z., Brenner, C. & Mericskay, M., 2018, In: Circulation. 137, 21, p. 2256-2273 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans
Morville, T., Sahl, Ronni Eg, Trammell, Sam, Svenningsen, J. S., Gillum, M. P., Helge, Jørn Wulff & Clemmensen, Christoffer, 2018, In: JCI Insight. 3, 15, p. 1-13 e122737.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest
Søberg, S., Andersen, E. S., Dalsgaard, N. B., Jarlhelt, I., Hansen, N. L., Hoffmann, N., Vilsbøll, Tina, Chenchar, A., Jensen, M., Grevengoed, Trisha Jean, Trammell, Sam, Knop, Filip Krag & Gillum, M. P., 2018, In: Molecular Metabolism. 11, p. 96-103 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
Discovery and characterization of novel nonsubstrate and substrate NAMPT inhibitors
Wilsbacher, J. L., Cheng, M., Cheng, D., Trammell, S. A. J., Shi, Y., Guo, J., Koeniger, S. L., Kovar, P. J., He, Y., Selvaraju, S., Heyman, H. R., Sorensen, B. K., Clark, R. F., Hansen, T. M., Longenecker, K. L., Raich, D., Korepanova, A. V., Cepa, S., Towne, D. L., Abraham, V. C. & 13 others, , 2017, In: Molecular Cancer Therapeutics. 16, 7, p. 1236-1245 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells
Ratajczak, J., Joffraud, M., Trammell, Sam, Ras, R., Canela, N., Boutant, M., Kulkarni, S. S., Rodrigues, M., Redpath, P., Migaud, M. E., Auwerx, J., Yanes, O., Brenner, C. & Cantó, C., 11 Oct 2016, In: Nature Communications. 7, 13103.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nicotinamide riboside is a major NAD+ precursor vitamin in cow milk
Trammell, Sam, Y., L., Redpath, P., Migaud, M. E. & Brenner, C., 1 May 2016, In: Journal of Nutrition. 146, 5, p. 957-963 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Trammell, Sam, Schmidt, M. S., Weidemann, B. J., Redpath, P., Jaksch, F., Dellinger, R. W., Li, Z., Abel, E. D., Migaud, M. E. & Brenner, C., 10 Oct 2016, In: Nature Communications. 7, 12948.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nicotinamide riboside opposes type 2 diabetes and neuropathy in mice
Trammell, Sam, Weidemann, B. J., Chadda, A., Yorek, M. S., Holmes, A., Coppey, L. J., Obrosov, A., Kardon, R. H., Yorek, M. A. & Brenner, C., 27 May 2016, In: Scientific Reports. 6, 26933.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
NNMT: A Bad Actor in Fat Makes Good in Liver
Trammell, Sam & Brenner, C., 4 Aug 2015, In: Cell Metabolism. 22, 2, p. 200-201 2 p.Research output: Contribution to journal › Editorial › Research › peer-review
- 2013
Targeted, LCMS-based metabolomics for quantitative measurement of NAD+ metabolites
Trammell, Sam & Brenner, C., 2013, In: Computational and Structural Biotechnology Journal. 4, 5, e201301012.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside
Midtkandal, R. R., Redpath, P., Trammell, Sam, MacDonald, S. J. F., Brenner, C. & Migaud, M. E., 15 Aug 2012, In: Bioorganic and Medicinal Chemistry Letters. 22, 16, p. 5204-5207 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 138358551
Most downloads
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249
downloads
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
150
downloads
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
127
downloads
FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest
Research output: Contribution to journal › Journal article › Research › peer-review
Published