Translational implications of bradyarrhythmia in hibernating brown bears

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Translational implications of bradyarrhythmia in hibernating brown bears. / Gottlieb, Lisa A.; Evans, Alina L.; Fuchs, Boris; Fröbert, Ole; Björkenheim, Anna.

I: Physiological Reports, Bind 11, Nr. 1, e15550, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gottlieb, LA, Evans, AL, Fuchs, B, Fröbert, O & Björkenheim, A 2023, 'Translational implications of bradyarrhythmia in hibernating brown bears', Physiological Reports, bind 11, nr. 1, e15550. https://doi.org/10.14814/phy2.15550

APA

Gottlieb, L. A., Evans, A. L., Fuchs, B., Fröbert, O., & Björkenheim, A. (2023). Translational implications of bradyarrhythmia in hibernating brown bears. Physiological Reports, 11(1), [e15550]. https://doi.org/10.14814/phy2.15550

Vancouver

Gottlieb LA, Evans AL, Fuchs B, Fröbert O, Björkenheim A. Translational implications of bradyarrhythmia in hibernating brown bears. Physiological Reports. 2023;11(1). e15550. https://doi.org/10.14814/phy2.15550

Author

Gottlieb, Lisa A. ; Evans, Alina L. ; Fuchs, Boris ; Fröbert, Ole ; Björkenheim, Anna. / Translational implications of bradyarrhythmia in hibernating brown bears. I: Physiological Reports. 2023 ; Bind 11, Nr. 1.

Bibtex

@article{c2a3c8566a03434084daf3b0bcec1155,
title = "Translational implications of bradyarrhythmia in hibernating brown bears",
abstract = "The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.",
keywords = "Ursus arctos, bradyarrhythmia, brown bear, hibernation, sinus arrest, sinus node disease, sinus pause, syncope, translational model",
author = "Gottlieb, {Lisa A.} and Evans, {Alina L.} and Boris Fuchs and Ole Fr{\"o}bert and Anna Bj{\"o}rkenheim",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.",
year = "2023",
doi = "10.14814/phy2.15550",
language = "English",
volume = "11",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "Wiley Periodicals, Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Translational implications of bradyarrhythmia in hibernating brown bears

AU - Gottlieb, Lisa A.

AU - Evans, Alina L.

AU - Fuchs, Boris

AU - Fröbert, Ole

AU - Björkenheim, Anna

N1 - Publisher Copyright: © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.

PY - 2023

Y1 - 2023

N2 - The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.

AB - The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.

KW - Ursus arctos

KW - bradyarrhythmia

KW - brown bear

KW - hibernation

KW - sinus arrest

KW - sinus node disease

KW - sinus pause

KW - syncope

KW - translational model

UR - http://www.scopus.com/inward/record.url?scp=85145430728&partnerID=8YFLogxK

U2 - 10.14814/phy2.15550

DO - 10.14814/phy2.15550

M3 - Journal article

C2 - 36597216

AN - SCOPUS:85145430728

VL - 11

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 1

M1 - e15550

ER -

ID: 332193738