Aquaglyceroporins and orthodox aquaporins in human adipocytes

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Aquaglyceroporins and orthodox aquaporins in human adipocytes. / Huang, Peng; Hansen, Jesper S; Saba, Karim H; Bergman, Anna; Negoita, Florentina; Gourdon, Pontus; Hagström-Andersson, Anna; Lindkvist-Petersson, Karin.

I: B B A - Biomembranes, Bind 1864, Nr. 1, 183795, 01.02.2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Huang, P, Hansen, JS, Saba, KH, Bergman, A, Negoita, F, Gourdon, P, Hagström-Andersson, A & Lindkvist-Petersson, K 2022, 'Aquaglyceroporins and orthodox aquaporins in human adipocytes', B B A - Biomembranes, bind 1864, nr. 1, 183795. https://doi.org/10.1016/j.bbamem.2021.183795

APA

Huang, P., Hansen, J. S., Saba, K. H., Bergman, A., Negoita, F., Gourdon, P., Hagström-Andersson, A., & Lindkvist-Petersson, K. (2022). Aquaglyceroporins and orthodox aquaporins in human adipocytes. B B A - Biomembranes, 1864(1), [183795]. https://doi.org/10.1016/j.bbamem.2021.183795

Vancouver

Huang P, Hansen JS, Saba KH, Bergman A, Negoita F, Gourdon P o.a. Aquaglyceroporins and orthodox aquaporins in human adipocytes. B B A - Biomembranes. 2022 feb. 1;1864(1). 183795. https://doi.org/10.1016/j.bbamem.2021.183795

Author

Huang, Peng ; Hansen, Jesper S ; Saba, Karim H ; Bergman, Anna ; Negoita, Florentina ; Gourdon, Pontus ; Hagström-Andersson, Anna ; Lindkvist-Petersson, Karin. / Aquaglyceroporins and orthodox aquaporins in human adipocytes. I: B B A - Biomembranes. 2022 ; Bind 1864, Nr. 1.

Bibtex

@article{26837382a3ca4952b2d167f2a76071a8,

title = "Aquaglyceroporins and orthodox aquaporins in human adipocytes",

abstract = "Aquaporins play a crucial role in water homeostasis in the human body, and recently the physiological importance of aquaporins as glycerol channels have been demonstrated. The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Adipocytes are the major source of glycerol and during lipolysis, glycerol is released to be metabolized by other tissues through a well-orchestrated process. Here we show that both AQP3 and AQP7 bind to the lipid droplet protein perilipin 1 (PLIN1), suggesting that PLIN1 is involved in the coordination of the subcellular translocation of aquaglyceroporins in human adipocytes. Moreover, in addition to aquaglyceroporins, we discovered by transcriptome sequencing that AQP1 is expressed in human primary adipocytes. AQP1 is mainly a water channel and thus is thought to be involved in the response to hyper-osmotic stress by efflux of water during hyperglycemia. Thus, this data suggests a contribution of both orthodox aquaporin and aquaglyceroporin in human adipocytes to maintain the homeostasis of glycerol and water during fasting and feeding.",

keywords = "Adipocytes/metabolism, Aquaglyceroporins/genetics, Aquaporin 1/genetics, Aquaporin 3/genetics, Aquaporins/genetics, Gene Expression Regulation/genetics, Glycerol/metabolism, Homeostasis/genetics, Humans, Hyperglycemia/genetics, Perilipin-1/genetics, Transcriptome/genetics, Water/metabolism",

author = "Peng Huang and Hansen, {Jesper S} and Saba, {Karim H} and Anna Bergman and Florentina Negoita and Pontus Gourdon and Anna Hagstr{\"o}m-Andersson and Karin Lindkvist-Petersson",

year = "2022",

month = feb,

day = "1",

doi = "10.1016/j.bbamem.2021.183795",

language = "English",

volume = "1864",

journal = "B B A - Biomembranes",

issn = "0005-2736",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Aquaglyceroporins and orthodox aquaporins in human adipocytes

AU - Huang, Peng

AU - Hansen, Jesper S

AU - Saba, Karim H

AU - Bergman, Anna

AU - Negoita, Florentina

AU - Gourdon, Pontus

AU - Hagström-Andersson, Anna

AU - Lindkvist-Petersson, Karin

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Aquaporins play a crucial role in water homeostasis in the human body, and recently the physiological importance of aquaporins as glycerol channels have been demonstrated. The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Adipocytes are the major source of glycerol and during lipolysis, glycerol is released to be metabolized by other tissues through a well-orchestrated process. Here we show that both AQP3 and AQP7 bind to the lipid droplet protein perilipin 1 (PLIN1), suggesting that PLIN1 is involved in the coordination of the subcellular translocation of aquaglyceroporins in human adipocytes. Moreover, in addition to aquaglyceroporins, we discovered by transcriptome sequencing that AQP1 is expressed in human primary adipocytes. AQP1 is mainly a water channel and thus is thought to be involved in the response to hyper-osmotic stress by efflux of water during hyperglycemia. Thus, this data suggests a contribution of both orthodox aquaporin and aquaglyceroporin in human adipocytes to maintain the homeostasis of glycerol and water during fasting and feeding.

AB - Aquaporins play a crucial role in water homeostasis in the human body, and recently the physiological importance of aquaporins as glycerol channels have been demonstrated. The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Adipocytes are the major source of glycerol and during lipolysis, glycerol is released to be metabolized by other tissues through a well-orchestrated process. Here we show that both AQP3 and AQP7 bind to the lipid droplet protein perilipin 1 (PLIN1), suggesting that PLIN1 is involved in the coordination of the subcellular translocation of aquaglyceroporins in human adipocytes. Moreover, in addition to aquaglyceroporins, we discovered by transcriptome sequencing that AQP1 is expressed in human primary adipocytes. AQP1 is mainly a water channel and thus is thought to be involved in the response to hyper-osmotic stress by efflux of water during hyperglycemia. Thus, this data suggests a contribution of both orthodox aquaporin and aquaglyceroporin in human adipocytes to maintain the homeostasis of glycerol and water during fasting and feeding.

KW - Adipocytes/metabolism

KW - Aquaglyceroporins/genetics

KW - Aquaporin 1/genetics

KW - Aquaporin 3/genetics

KW - Aquaporins/genetics

KW - Gene Expression Regulation/genetics

KW - Glycerol/metabolism

KW - Homeostasis/genetics

KW - Humans

KW - Hyperglycemia/genetics

KW - Perilipin-1/genetics

KW - Transcriptome/genetics

KW - Water/metabolism

U2 - 10.1016/j.bbamem.2021.183795

DO - 10.1016/j.bbamem.2021.183795

M3 - Journal article

C2 - 34627746

VL - 1864

JO - B B A - Biomembranes

JF - B B A - Biomembranes

SN - 0005-2736

IS - 1

M1 - 183795

ER -

ID: 338428991

Biomedicinsk Institut