Molecular Insights From Multiomics Studies of Physical Activity

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Molecular Insights From Multiomics Studies of Physical Activity. / Wei, Wei; Raun, Steffen H.; Long, Jonathan Z.

In: Diabetes, Vol. 73, No. 2, 01.02.2024, p. 162-168.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wei, W, Raun, SH & Long, JZ 2024, 'Molecular Insights From Multiomics Studies of Physical Activity', Diabetes, vol. 73, no. 2, pp. 162-168. https://doi.org/10.2337/dbi23-0004

APA

Wei, W., Raun, S. H., & Long, J. Z. (2024). Molecular Insights From Multiomics Studies of Physical Activity. Diabetes, 73(2), 162-168. https://doi.org/10.2337/dbi23-0004

Vancouver

Wei W, Raun SH, Long JZ. Molecular Insights From Multiomics Studies of Physical Activity. Diabetes. 2024 Feb 1;73(2):162-168. https://doi.org/10.2337/dbi23-0004

Author

Wei, Wei ; Raun, Steffen H. ; Long, Jonathan Z. / Molecular Insights From Multiomics Studies of Physical Activity. In: Diabetes. 2024 ; Vol. 73, No. 2. pp. 162-168.

Bibtex

@article{f94115903e4d4e7780805ab8d81f3fac,
title = "Molecular Insights From Multiomics Studies of Physical Activity",
abstract = "Physical activity confers systemic health benefits and provides powerful protection against disease. There has been tremendous interest in understanding the molecular effectors of exercise that mediate these physiologic effects. The modern growth of multiomics technologies-including metabolomics, proteomics, phosphoproteomics, lipidomics, single-cell RNA sequencing, and epigenomics-has provided unparalleled opportunities to systematically investigate the molecular changes associated with physical activity on an organism-wide scale. Here, we discuss how multiomics technologies provide new insights into the systemic effects of physical activity, including the integrative responses across organs as well as the molecules and mechanisms mediating tissue communication during exercise. We also highlight critical unanswered questions that can now be addressed using these high-dimensional tools and provide perspectives on fertile future research directions.",
author = "Wei Wei and Raun, {Steffen H.} and Long, {Jonathan Z.}",
note = "Publisher Copyright: {\textcopyright} 2024 by the American Diabetes Association.",
year = "2024",
month = feb,
day = "1",
doi = "10.2337/dbi23-0004",
language = "English",
volume = "73",
pages = "162--168",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "2",

}

RIS

TY - JOUR

T1 - Molecular Insights From Multiomics Studies of Physical Activity

AU - Wei, Wei

AU - Raun, Steffen H.

AU - Long, Jonathan Z.

N1 - Publisher Copyright: © 2024 by the American Diabetes Association.

PY - 2024/2/1

Y1 - 2024/2/1

N2 - Physical activity confers systemic health benefits and provides powerful protection against disease. There has been tremendous interest in understanding the molecular effectors of exercise that mediate these physiologic effects. The modern growth of multiomics technologies-including metabolomics, proteomics, phosphoproteomics, lipidomics, single-cell RNA sequencing, and epigenomics-has provided unparalleled opportunities to systematically investigate the molecular changes associated with physical activity on an organism-wide scale. Here, we discuss how multiomics technologies provide new insights into the systemic effects of physical activity, including the integrative responses across organs as well as the molecules and mechanisms mediating tissue communication during exercise. We also highlight critical unanswered questions that can now be addressed using these high-dimensional tools and provide perspectives on fertile future research directions.

AB - Physical activity confers systemic health benefits and provides powerful protection against disease. There has been tremendous interest in understanding the molecular effectors of exercise that mediate these physiologic effects. The modern growth of multiomics technologies-including metabolomics, proteomics, phosphoproteomics, lipidomics, single-cell RNA sequencing, and epigenomics-has provided unparalleled opportunities to systematically investigate the molecular changes associated with physical activity on an organism-wide scale. Here, we discuss how multiomics technologies provide new insights into the systemic effects of physical activity, including the integrative responses across organs as well as the molecules and mechanisms mediating tissue communication during exercise. We also highlight critical unanswered questions that can now be addressed using these high-dimensional tools and provide perspectives on fertile future research directions.

U2 - 10.2337/dbi23-0004

DO - 10.2337/dbi23-0004

M3 - Journal article

C2 - 38241506

AN - SCOPUS:85182850690

VL - 73

SP - 162

EP - 168

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 2

ER -

ID: 381502970