Identification and characterization of protein cross-links induced by oxidative reactions

Research output: Contribution to journal › Review › Research › peer-review

Standard

Identification and characterization of protein cross-links induced by oxidative reactions. / Hagglund, Per; Mariotti, Michele; Davies, Michael J.

In: Expert Review of Proteomics, Vol. 15, No. 8, 2018, p. 665-681.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Hagglund, P, Mariotti, M & Davies, MJ 2018, 'Identification and characterization of protein cross-links induced by oxidative reactions', Expert Review of Proteomics, vol. 15, no. 8, pp. 665-681. https://doi.org/10.1080/14789450.2018.1509710

APA

Hagglund, P., Mariotti, M., & Davies, M. J. (2018). Identification and characterization of protein cross-links induced by oxidative reactions. Expert Review of Proteomics, 15(8), 665-681. https://doi.org/10.1080/14789450.2018.1509710

Vancouver

Hagglund P, Mariotti M, Davies MJ. Identification and characterization of protein cross-links induced by oxidative reactions. Expert Review of Proteomics. 2018;15(8):665-681. https://doi.org/10.1080/14789450.2018.1509710

Author

Hagglund, Per ; Mariotti, Michele ; Davies, Michael J. / Identification and characterization of protein cross-links induced by oxidative reactions. In: Expert Review of Proteomics. 2018 ; Vol. 15, No. 8. pp. 665-681.

Bibtex

@article{6527e35340584660ac0de887df7dd7a0,
title = "Identification and characterization of protein cross-links induced by oxidative reactions",
abstract = "Introduction: Protein cross-links are common in biological systems and are generated both deliberately as a part of normal metabolism and also accidently as a result of exposure to external factors such as oxidation and glycation stresses. These cross-links can be both positive and negative for biological function, with high levels of inappropriate cross-links being associated with multiple human pathologies, as well as loss of protein structure and function in the food, agricultural, and pharmaceutical fields.Areas covered: This review covers recent advances in the detection and identification of protein cross-links arising from oxidation reactions, mediated by both radicals and two-electron oxidants. Information on both enzymatic and nonenzymatic cross-linking is reviewed, both where this is intentional, as part of normal metabolism, and accidental and a potential cause of disease.Expert commentary: The advantages and drawbacks of various methods available for the detection, identification, and quantification of these species are discussed, as well as some of the mechanisms and processes known to give rise to these species.",
keywords = "Protein oxidation, cross-linking, mass spectrometry",
author = "Per Hagglund and Michele Mariotti and Davies, {Michael J.}",
year = "2018",
doi = "10.1080/14789450.2018.1509710",
language = "English",
volume = "15",
pages = "665--681",
journal = "Expert Review of Proteomics",
issn = "1478-9450",
publisher = "Taylor & Francis",
number = "8",

}

RIS

TY - JOUR

T1 - Identification and characterization of protein cross-links induced by oxidative reactions

AU - Hagglund, Per

AU - Mariotti, Michele

AU - Davies, Michael J.

PY - 2018

Y1 - 2018

N2 - Introduction: Protein cross-links are common in biological systems and are generated both deliberately as a part of normal metabolism and also accidently as a result of exposure to external factors such as oxidation and glycation stresses. These cross-links can be both positive and negative for biological function, with high levels of inappropriate cross-links being associated with multiple human pathologies, as well as loss of protein structure and function in the food, agricultural, and pharmaceutical fields.Areas covered: This review covers recent advances in the detection and identification of protein cross-links arising from oxidation reactions, mediated by both radicals and two-electron oxidants. Information on both enzymatic and nonenzymatic cross-linking is reviewed, both where this is intentional, as part of normal metabolism, and accidental and a potential cause of disease.Expert commentary: The advantages and drawbacks of various methods available for the detection, identification, and quantification of these species are discussed, as well as some of the mechanisms and processes known to give rise to these species.

AB - Introduction: Protein cross-links are common in biological systems and are generated both deliberately as a part of normal metabolism and also accidently as a result of exposure to external factors such as oxidation and glycation stresses. These cross-links can be both positive and negative for biological function, with high levels of inappropriate cross-links being associated with multiple human pathologies, as well as loss of protein structure and function in the food, agricultural, and pharmaceutical fields.Areas covered: This review covers recent advances in the detection and identification of protein cross-links arising from oxidation reactions, mediated by both radicals and two-electron oxidants. Information on both enzymatic and nonenzymatic cross-linking is reviewed, both where this is intentional, as part of normal metabolism, and accidental and a potential cause of disease.Expert commentary: The advantages and drawbacks of various methods available for the detection, identification, and quantification of these species are discussed, as well as some of the mechanisms and processes known to give rise to these species.

KW - Protein oxidation

KW - cross-linking

KW - mass spectrometry

U2 - 10.1080/14789450.2018.1509710

DO - 10.1080/14789450.2018.1509710

M3 - Review

C2 - 30091671

VL - 15

SP - 665

EP - 681

JO - Expert Review of Proteomics

JF - Expert Review of Proteomics

SN - 1478-9450

IS - 8

ER -

ID: 210610120