TY - JOUR

T1 - Early risk stratification using Rubidium-82 positron emission tomography in STEMI patients

AU - Ghotbi, Adam Ali

AU - Hasbak, Philip

AU - Nepper-Christensen, Lars

AU - Lønborg, Jacob

AU - Atharovski, Kiril

AU - Christensen, Thomas

AU - Holmvang, Lene

AU - Engstrøm, Thomas

AU - Ripa, Rasmus Sejersten

AU - Kjær, Andreas

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Assessment of infarct size after myocardial infarction is predictive of subsequent morphological changes and clinical outcome. This study aimed to assess subacute post-intervention Rubidium-82 ((82)Rb)-PET imaging in predicting left ventricle ejection fraction, regional wall motion, and final infarct size by CMR at 3-months after STEMI.METHODS: STEMI patients undergoing percutaneous coronary intervention were included prospectively. Rest-only (82)Rb-PET perfusion imaging was performed at median 36 hours [IQR: 22 to 50] after the treatment. The extent of hypoperfusion and absolute blood flow (mL·min·g) were estimated on a global and a 17-segment model with dedicated software. At 3-months follow-up patients completed the CMR functional and late gadolinium enhancement imaging.RESULTS: 42 patients were included, but only 35 had follow-up CMR and constituted the study population. Absolute blood flow was significantly lower in the infarct-related territory compared to remote myocardium, P < .005. Extent of hypoperfusion correlated with final infarct size, r = 0.58, P < .001, while blood flow correlated with ejection fraction, r = 0.41, P < .05. In linear mixed models, higher subacute absolute blood flow (β = 4.6, confidence interval [3.5; 5.2], P < .001, R (2) = 0.67) was associated with greater wall motion. Segmental extent of subacute hypoperfusion (β = 0.43 [0.38; 0.49], P < .001, R (2) = 0.58) was associated with the degree of late gadolinium enhancement at 3-months.CONCLUSIONS: Subacute rest-only (82)Rb-PET is feasible following STEMI and seems predictive of myocardial function and infarct size at 3-months.

AB - BACKGROUND: Assessment of infarct size after myocardial infarction is predictive of subsequent morphological changes and clinical outcome. This study aimed to assess subacute post-intervention Rubidium-82 ((82)Rb)-PET imaging in predicting left ventricle ejection fraction, regional wall motion, and final infarct size by CMR at 3-months after STEMI.METHODS: STEMI patients undergoing percutaneous coronary intervention were included prospectively. Rest-only (82)Rb-PET perfusion imaging was performed at median 36 hours [IQR: 22 to 50] after the treatment. The extent of hypoperfusion and absolute blood flow (mL·min·g) were estimated on a global and a 17-segment model with dedicated software. At 3-months follow-up patients completed the CMR functional and late gadolinium enhancement imaging.RESULTS: 42 patients were included, but only 35 had follow-up CMR and constituted the study population. Absolute blood flow was significantly lower in the infarct-related territory compared to remote myocardium, P < .005. Extent of hypoperfusion correlated with final infarct size, r = 0.58, P < .001, while blood flow correlated with ejection fraction, r = 0.41, P < .05. In linear mixed models, higher subacute absolute blood flow (β = 4.6, confidence interval [3.5; 5.2], P < .001, R (2) = 0.67) was associated with greater wall motion. Segmental extent of subacute hypoperfusion (β = 0.43 [0.38; 0.49], P < .001, R (2) = 0.58) was associated with the degree of late gadolinium enhancement at 3-months.CONCLUSIONS: Subacute rest-only (82)Rb-PET is feasible following STEMI and seems predictive of myocardial function and infarct size at 3-months.

KW - Journal Article

U2 - 10.1007/s12350-017-0993-x

DO - 10.1007/s12350-017-0993-x

M3 - Journal article

C2 - 28718077

VL - 26

SP - 471

EP - 482

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

ER -