Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?
Research output: Contribution to journal › Journal article › Research › peer-review
Voltage- and Ca(2+)-dependent K(+) channels in the membrane of both T and B lymphocytes are important for the cellular immune response. In the current issue of the European Journal of Immunology, Reich et al. demonstrate that selective blockade of the intermediate-conductance Ca(2+)-activated K(+) channel (the IK channel encoded by the KCNN4 gene) prevents cytokine production in the spinal chord and ameliorates the development of EAE caused by injection of myelin oligodendrocyte glycoprotein (MOG)(35-55) in mice. These data renew the focus on the IK channel as a potential target for the development of new immune-suppressant drugs for the treatment of autoimmune diseases.
Original language | English |
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Journal | European Journal of Immunology |
Volume | 35 |
Issue number | 4 |
Pages (from-to) | 1023-6 |
Number of pages | 3 |
ISSN | 0014-2980 |
DOIs | |
Publication status | Published - 2005 |
Bibliographical note
Keywords: Animals; Mice; Multiple Sclerosis; Potassium Channels, Calcium-Activated; T-Lymphocytes
ID: 8466454