Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis? / Madsen, Lars Siim; Christophersen, Palle; Olesen, Søren-Peter.

In: European Journal of Immunology, Vol. 35, No. 4, 2005, p. 1023-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Madsen, LS, Christophersen, P & Olesen, S-P 2005, 'Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?', European Journal of Immunology, vol. 35, no. 4, pp. 1023-6. https://doi.org/10.1002/eji.200526078

APA

Madsen, L. S., Christophersen, P., & Olesen, S-P. (2005). Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis? European Journal of Immunology, 35(4), 1023-6. https://doi.org/10.1002/eji.200526078

Vancouver

Madsen LS, Christophersen P, Olesen S-P. Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis? European Journal of Immunology. 2005;35(4):1023-6. https://doi.org/10.1002/eji.200526078

Author

Madsen, Lars Siim ; Christophersen, Palle ; Olesen, Søren-Peter. / Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?. In: European Journal of Immunology. 2005 ; Vol. 35, No. 4. pp. 1023-6.

Bibtex

@article{02cf5b00acd811ddb538000ea68e967b,
title = "Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?",
abstract = "Voltage- and Ca(2+)-dependent K(+) channels in the membrane of both T and B lymphocytes are important for the cellular immune response. In the current issue of the European Journal of Immunology, Reich et al. demonstrate that selective blockade of the intermediate-conductance Ca(2+)-activated K(+) channel (the IK channel encoded by the KCNN4 gene) prevents cytokine production in the spinal chord and ameliorates the development of EAE caused by injection of myelin oligodendrocyte glycoprotein (MOG)(35-55) in mice. These data renew the focus on the IK channel as a potential target for the development of new immune-suppressant drugs for the treatment of autoimmune diseases.",
author = "Madsen, {Lars Siim} and Palle Christophersen and S{\o}ren-Peter Olesen",
note = "Keywords: Animals; Mice; Multiple Sclerosis; Potassium Channels, Calcium-Activated; T-Lymphocytes",
year = "2005",
doi = "10.1002/eji.200526078",
language = "English",
volume = "35",
pages = "1023--6",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "4",

}

RIS

TY - JOUR

T1 - Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?

AU - Madsen, Lars Siim

AU - Christophersen, Palle

AU - Olesen, Søren-Peter

N1 - Keywords: Animals; Mice; Multiple Sclerosis; Potassium Channels, Calcium-Activated; T-Lymphocytes

PY - 2005

Y1 - 2005

N2 - Voltage- and Ca(2+)-dependent K(+) channels in the membrane of both T and B lymphocytes are important for the cellular immune response. In the current issue of the European Journal of Immunology, Reich et al. demonstrate that selective blockade of the intermediate-conductance Ca(2+)-activated K(+) channel (the IK channel encoded by the KCNN4 gene) prevents cytokine production in the spinal chord and ameliorates the development of EAE caused by injection of myelin oligodendrocyte glycoprotein (MOG)(35-55) in mice. These data renew the focus on the IK channel as a potential target for the development of new immune-suppressant drugs for the treatment of autoimmune diseases.

AB - Voltage- and Ca(2+)-dependent K(+) channels in the membrane of both T and B lymphocytes are important for the cellular immune response. In the current issue of the European Journal of Immunology, Reich et al. demonstrate that selective blockade of the intermediate-conductance Ca(2+)-activated K(+) channel (the IK channel encoded by the KCNN4 gene) prevents cytokine production in the spinal chord and ameliorates the development of EAE caused by injection of myelin oligodendrocyte glycoprotein (MOG)(35-55) in mice. These data renew the focus on the IK channel as a potential target for the development of new immune-suppressant drugs for the treatment of autoimmune diseases.

U2 - 10.1002/eji.200526078

DO - 10.1002/eji.200526078

M3 - Journal article

C2 - 15770695

VL - 35

SP - 1023

EP - 1026

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 4

ER -

ID: 8466454