Z-score transformation of T-wave morphology values to a standardized scale

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Drugs that prolong the QTc interval to clinically relevant magnitudes are likely to be proarrhythmic if they also produce relevant changes in the morphology of repolarization waveforms. Concurrent analyses of QTc and the T-wave Morphology Combination Score (MCS) have already shown how this approach can improve characterization of repolarization effects for a number of drugs. In this study we develop a transformation of MCS values to standardized T-wave Morphology scores (TWM) which have the important advantage of being directly comparable to QTc. We then examined the relative merits of assessing changes in TWM values in addition to QTcF for 37 schizophrenia subjects exposed to Sertindole, a drug which is not considered acceptably safe as a broad treatment of schizophrenia.

Original languageEnglish
Title of host publicationComputing in Cardiology 2011, CinC 2011
Number of pages4
Publication date1 Dec 2011
Article number6164671
ISBN (Print)9781457706127
Publication statusPublished - 1 Dec 2011
EventComputing in Cardiology 2011, CinC 2011 - Hangzhou, China
Duration: 18 Sep 201121 Sep 2011


ConferenceComputing in Cardiology 2011, CinC 2011
SponsorEuropean Society of Cardiology, Zhejiang University, EMB, IEEE, Drager

ID: 204298799