What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?

Research output: Contribution to journal › Review › Research › peer-review

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What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? / Kuhre, Rune E.; Deacon, Carolyn F.; Holst, Jens J.; Petersen, Natalia.

In: Frontiers in Endocrinology, Vol. 12, 694284, 2021.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Kuhre, RE, Deacon, CF, Holst, JJ & Petersen, N 2021, 'What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?', Frontiers in Endocrinology, vol. 12, 694284. https://doi.org/10.3389/fendo.2021.694284

APA

Kuhre, R. E., Deacon, C. F., Holst, J. J., & Petersen, N. (2021). What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? Frontiers in Endocrinology, 12, [694284]. https://doi.org/10.3389/fendo.2021.694284

Vancouver

Kuhre RE, Deacon CF, Holst JJ, Petersen N. What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell? Frontiers in Endocrinology. 2021;12. 694284. https://doi.org/10.3389/fendo.2021.694284

Author

Kuhre, Rune E. ; Deacon, Carolyn F. ; Holst, Jens J. ; Petersen, Natalia. / What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?. In: Frontiers in Endocrinology. 2021 ; Vol. 12.

Bibtex

@article{21186d21aa2c484da9be2c22359824fe,
title = "What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?",
abstract = "Synthetic glucagon-like peptide-1 (GLP-1) analogues are effective anti-obesity and anti-diabetes drugs. The beneficial actions of GLP-1 go far beyond insulin secretion and appetite, and include cardiovascular benefits and possibly also beneficial effects in neurodegenerative diseases. Considerable reserves of GLP-1 are stored in intestinal endocrine cells that potentially might be mobilized by pharmacological means to improve the body's metabolic state. In recognition of this, the interest in understanding basic L-cell physiology and the mechanisms controlling GLP-1 secretion, has increased considerably. With a view to home in on what an L-cell is, we here present an overview of available data on L-cell development, L-cell peptide expression profiles, peptide production and secretory patterns of L-cells from different parts of the gut. We conclude that L-cells differ markedly depending on their anatomical location, and that the traditional definition of L-cells as a homogeneous population of cells that only produce GLP-1, GLP-2, glicentin and oxyntomodulin is no longer tenable. We suggest to sub-classify L-cells based on their differential peptide contents as well as their differential expression of nutrient sensors, which ultimately determine the secretory responses to different stimuli. A second purpose of this review is to describe and discuss the most frequently used experimental models for functional L-cell studies, highlighting their benefits and limitations. We conclude that no experimental model is perfect and that a comprehensive understanding must be built on results from a combination of models.",
keywords = "L-cell, GLP-1, glucagon-like peptide-1, experimental, animal models, in vitro model, hormone secretion, peptide expression, GLUCAGON-LIKE PEPTIDE-1, Y GASTRIC BYPASS, ENTEROENDOCRINE L-CELLS, SHORT-BOWEL PATIENTS, GASTROINTESTINAL-TRACT, SMALL-INTESTINE, INHIBITORY POLYPEPTIDE, SLEEVE GASTRECTOMY, INSULIN-SECRETION, PROGLUCAGON GENE",
author = "Kuhre, {Rune E.} and Deacon, {Carolyn F.} and Holst, {Jens J.} and Natalia Petersen",
year = "2021",
doi = "10.3389/fendo.2021.694284",
language = "English",
volume = "12",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?

AU - Kuhre, Rune E.

AU - Deacon, Carolyn F.

AU - Holst, Jens J.

AU - Petersen, Natalia

PY - 2021

Y1 - 2021

N2 - Synthetic glucagon-like peptide-1 (GLP-1) analogues are effective anti-obesity and anti-diabetes drugs. The beneficial actions of GLP-1 go far beyond insulin secretion and appetite, and include cardiovascular benefits and possibly also beneficial effects in neurodegenerative diseases. Considerable reserves of GLP-1 are stored in intestinal endocrine cells that potentially might be mobilized by pharmacological means to improve the body's metabolic state. In recognition of this, the interest in understanding basic L-cell physiology and the mechanisms controlling GLP-1 secretion, has increased considerably. With a view to home in on what an L-cell is, we here present an overview of available data on L-cell development, L-cell peptide expression profiles, peptide production and secretory patterns of L-cells from different parts of the gut. We conclude that L-cells differ markedly depending on their anatomical location, and that the traditional definition of L-cells as a homogeneous population of cells that only produce GLP-1, GLP-2, glicentin and oxyntomodulin is no longer tenable. We suggest to sub-classify L-cells based on their differential peptide contents as well as their differential expression of nutrient sensors, which ultimately determine the secretory responses to different stimuli. A second purpose of this review is to describe and discuss the most frequently used experimental models for functional L-cell studies, highlighting their benefits and limitations. We conclude that no experimental model is perfect and that a comprehensive understanding must be built on results from a combination of models.

AB - Synthetic glucagon-like peptide-1 (GLP-1) analogues are effective anti-obesity and anti-diabetes drugs. The beneficial actions of GLP-1 go far beyond insulin secretion and appetite, and include cardiovascular benefits and possibly also beneficial effects in neurodegenerative diseases. Considerable reserves of GLP-1 are stored in intestinal endocrine cells that potentially might be mobilized by pharmacological means to improve the body's metabolic state. In recognition of this, the interest in understanding basic L-cell physiology and the mechanisms controlling GLP-1 secretion, has increased considerably. With a view to home in on what an L-cell is, we here present an overview of available data on L-cell development, L-cell peptide expression profiles, peptide production and secretory patterns of L-cells from different parts of the gut. We conclude that L-cells differ markedly depending on their anatomical location, and that the traditional definition of L-cells as a homogeneous population of cells that only produce GLP-1, GLP-2, glicentin and oxyntomodulin is no longer tenable. We suggest to sub-classify L-cells based on their differential peptide contents as well as their differential expression of nutrient sensors, which ultimately determine the secretory responses to different stimuli. A second purpose of this review is to describe and discuss the most frequently used experimental models for functional L-cell studies, highlighting their benefits and limitations. We conclude that no experimental model is perfect and that a comprehensive understanding must be built on results from a combination of models.

KW - L-cell

KW - GLP-1

KW - glucagon-like peptide-1

KW - experimental

KW - animal models

KW - in vitro model

KW - hormone secretion

KW - peptide expression

KW - GLUCAGON-LIKE PEPTIDE-1

KW - Y GASTRIC BYPASS

KW - ENTEROENDOCRINE L-CELLS

KW - SHORT-BOWEL PATIENTS

KW - GASTROINTESTINAL-TRACT

KW - SMALL-INTESTINE

KW - INHIBITORY POLYPEPTIDE

KW - SLEEVE GASTRECTOMY

KW - INSULIN-SECRETION

KW - PROGLUCAGON GENE

U2 - 10.3389/fendo.2021.694284

DO - 10.3389/fendo.2021.694284

M3 - Review

C2 - 34168620

VL - 12

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

M1 - 694284

ER -

ID: 274061716