Weight-loss induced by carbohydrate restriction does not negatively affect health-related quality of life and cognition in people with type 2 diabetes: A randomised controlled trial
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Weight-loss induced by carbohydrate restriction does not negatively affect health-related quality of life and cognition in people with type 2 diabetes: A randomised controlled trial. / Jensen, Nicole Jacqueline; Wodschow, Helena Zander; Skytte, Mads Juul; Samkani, Amirsalar; Astrup, Arne; Frystyk, Jan; Hartmann, Bolette; Holst, Jens Juul; Larsen, Thomas Meinert; Madsbad, Sten; Magkos, Faidon; Miskowiak, Kamilla Woznica; Haugaard, Steen Bendix; Krarup, Thure; Rungby, Jørgen; Thomsen, Mads Norvin.
In: Clinical Nutrition, Vol. 41, No. 7, 2022, p. 1605-1612.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Weight-loss induced by carbohydrate restriction does not negatively affect health-related quality of life and cognition in people with type 2 diabetes: A randomised controlled trial
AU - Jensen, Nicole Jacqueline
AU - Wodschow, Helena Zander
AU - Skytte, Mads Juul
AU - Samkani, Amirsalar
AU - Astrup, Arne
AU - Frystyk, Jan
AU - Hartmann, Bolette
AU - Holst, Jens Juul
AU - Larsen, Thomas Meinert
AU - Madsbad, Sten
AU - Magkos, Faidon
AU - Miskowiak, Kamilla Woznica
AU - Haugaard, Steen Bendix
AU - Krarup, Thure
AU - Rungby, Jørgen
AU - Thomsen, Mads Norvin
N1 - Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Background & aims: We evaluated the effect of weight loss induced by dietary carbohydrate restriction on health-related quality of life (HRQoL) and cognition in type 2 diabetes (T2D).Methods: In this randomised parallel trial, 72 adults with T2D and overweight/obesity (mean ± SD, HbA1c: 57 ± 8 mmol/mol and BMI: 33 ± 5 kg/m2) were randomly assigned to a carbohydrate-reduced high-protein diet (CRHP: C30E%-P30E%-F40E%) or conventional diabetes diet (CD: C50E%-P17E%-F33E%) for 6 weeks, targeting a 6% weight loss. HRQoL was assessed from the short form 36 (SF-36) questionnaire, including physical and mental component summary (PCS and MCS) scores; global cognition, verbal memory, attention and psychomotor speed, and executive function were assessed from a neuropsychological test battery.Results: Both diet groups achieved a 5.8 kg weight loss and improved PCS (median [25th;75th percentiles], CD: 2.7 [1.1; 4.2] vs. CRHP: 2.1 [0.7; 3.7]), with no difference between diets. The CRHP diet resulted in a clinically relevant improvement of MCS, albeit non-significantly different compared with the change after the CD diet (2.0 [-0.7; 4.8], p = 0.15). Global cognition, attention, and verbal memory were unaffected by the CRHP diet, which selectively worsened the Symbol Digit Modality Test assessing psychomotor speed when compared with the CD diet (-4.1 [-7.2;-1.1], p < 0.01).Conclusion: Physical health improved by weight loss independently of macronutrient distribution, while mental health and cognition may be affected by the amount of carbohydrate, protein and fat in the diet. Collectively, our data suggest that weight loss through moderate carbohydrate restriction has no clinically important impact on HRQoL and global cognition in patients with T2D. Registered under ClinicalTrials.gov Identifier no. NCT03814694.
AB - Background & aims: We evaluated the effect of weight loss induced by dietary carbohydrate restriction on health-related quality of life (HRQoL) and cognition in type 2 diabetes (T2D).Methods: In this randomised parallel trial, 72 adults with T2D and overweight/obesity (mean ± SD, HbA1c: 57 ± 8 mmol/mol and BMI: 33 ± 5 kg/m2) were randomly assigned to a carbohydrate-reduced high-protein diet (CRHP: C30E%-P30E%-F40E%) or conventional diabetes diet (CD: C50E%-P17E%-F33E%) for 6 weeks, targeting a 6% weight loss. HRQoL was assessed from the short form 36 (SF-36) questionnaire, including physical and mental component summary (PCS and MCS) scores; global cognition, verbal memory, attention and psychomotor speed, and executive function were assessed from a neuropsychological test battery.Results: Both diet groups achieved a 5.8 kg weight loss and improved PCS (median [25th;75th percentiles], CD: 2.7 [1.1; 4.2] vs. CRHP: 2.1 [0.7; 3.7]), with no difference between diets. The CRHP diet resulted in a clinically relevant improvement of MCS, albeit non-significantly different compared with the change after the CD diet (2.0 [-0.7; 4.8], p = 0.15). Global cognition, attention, and verbal memory were unaffected by the CRHP diet, which selectively worsened the Symbol Digit Modality Test assessing psychomotor speed when compared with the CD diet (-4.1 [-7.2;-1.1], p < 0.01).Conclusion: Physical health improved by weight loss independently of macronutrient distribution, while mental health and cognition may be affected by the amount of carbohydrate, protein and fat in the diet. Collectively, our data suggest that weight loss through moderate carbohydrate restriction has no clinically important impact on HRQoL and global cognition in patients with T2D. Registered under ClinicalTrials.gov Identifier no. NCT03814694.
KW - Faculty of Science
KW - Carbohydrate restriction
KW - Cognition
KW - Dietary intervention
KW - Health-related quality of life
KW - Type 2 diabetes
KW - Weight loss
U2 - 10.1016/j.clnu.2022.05.005
DO - 10.1016/j.clnu.2022.05.005
M3 - Journal article
C2 - 35679680
VL - 41
SP - 1605
EP - 1612
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 7
ER -
ID: 310219421