Vasoactive intestinal polypeptide and acetylcholine stimulate exocrine secretion of epidermal growth factor from the rat submandibular gland

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Standard

Vasoactive intestinal polypeptide and acetylcholine stimulate exocrine secretion of epidermal growth factor from the rat submandibular gland. / Poulsen, Steen Seier; Nexø, Ebba.

In: Regulatory Peptides, Vol. 15, No. 1, 08.1986, p. 37-46.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS & Nexø, E 1986, 'Vasoactive intestinal polypeptide and acetylcholine stimulate exocrine secretion of epidermal growth factor from the rat submandibular gland', Regulatory Peptides, vol. 15, no. 1, pp. 37-46.

APA

Poulsen, S. S., & Nexø, E. (1986). Vasoactive intestinal polypeptide and acetylcholine stimulate exocrine secretion of epidermal growth factor from the rat submandibular gland. Regulatory Peptides, 15(1), 37-46.

Vancouver

Poulsen SS, Nexø E. Vasoactive intestinal polypeptide and acetylcholine stimulate exocrine secretion of epidermal growth factor from the rat submandibular gland. Regulatory Peptides. 1986 Aug;15(1):37-46.

Author

Poulsen, Steen Seier ; Nexø, Ebba. / Vasoactive intestinal polypeptide and acetylcholine stimulate exocrine secretion of epidermal growth factor from the rat submandibular gland. In: Regulatory Peptides. 1986 ; Vol. 15, No. 1. pp. 37-46.

Bibtex

@article{a95d203266ec4b29b7ea1e22b2eeec8f,
title = "Vasoactive intestinal polypeptide and acetylcholine stimulate exocrine secretion of epidermal growth factor from the rat submandibular gland",
abstract = "The effect of vasoactive intestinal polypeptide (VIP) and acetylcholine on secretion of epidermal growth factor (EGF) from the rat salivary glands was investigated. VIP in doses of 3 X 10(-10) to 3 X 10(-8) mol/kg per h stimulated secretion of saliva and total output of EGF dose-dependently. Acetylcholine also stimulated salivation and output of EGF. VIP in a dose of 3 X 10(-11) to 3 X 10(-10) mol/kg per h enhanced the stimulatory effect of acetylcholine, but this effect disappeared when the dose of VIP was increased. Adrenalectomy decreased acetylcholine stimulated total output of EGF by approximately 50%, but only by 20% when acetylcholine plus VIP was administered. EGF was localized to the convoluted granular tubules in the submandibular gland, whereas EGF could not be detected in the remaining salivary glands. The results suggest that VIP and acetylcholine cooperate in the control of exocrine secretion from the rat salivary glands. The effect of acetylcholine, however, seems to be partly dependent on circulating catecholamines.",
keywords = "Acetylcholine, Animals, Dose-Response Relationship, Drug, Epidermal Growth Factor, Male, Rats, Rats, Inbred Strains, Saliva, Submandibular Gland, Vasoactive Intestinal Peptide",
author = "Poulsen, {Steen Seier} and Ebba Nex{\o}",
year = "1986",
month = aug,
language = "English",
volume = "15",
pages = "37--46",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Vasoactive intestinal polypeptide and acetylcholine stimulate exocrine secretion of epidermal growth factor from the rat submandibular gland

AU - Poulsen, Steen Seier

AU - Nexø, Ebba

PY - 1986/8

Y1 - 1986/8

N2 - The effect of vasoactive intestinal polypeptide (VIP) and acetylcholine on secretion of epidermal growth factor (EGF) from the rat salivary glands was investigated. VIP in doses of 3 X 10(-10) to 3 X 10(-8) mol/kg per h stimulated secretion of saliva and total output of EGF dose-dependently. Acetylcholine also stimulated salivation and output of EGF. VIP in a dose of 3 X 10(-11) to 3 X 10(-10) mol/kg per h enhanced the stimulatory effect of acetylcholine, but this effect disappeared when the dose of VIP was increased. Adrenalectomy decreased acetylcholine stimulated total output of EGF by approximately 50%, but only by 20% when acetylcholine plus VIP was administered. EGF was localized to the convoluted granular tubules in the submandibular gland, whereas EGF could not be detected in the remaining salivary glands. The results suggest that VIP and acetylcholine cooperate in the control of exocrine secretion from the rat salivary glands. The effect of acetylcholine, however, seems to be partly dependent on circulating catecholamines.

AB - The effect of vasoactive intestinal polypeptide (VIP) and acetylcholine on secretion of epidermal growth factor (EGF) from the rat salivary glands was investigated. VIP in doses of 3 X 10(-10) to 3 X 10(-8) mol/kg per h stimulated secretion of saliva and total output of EGF dose-dependently. Acetylcholine also stimulated salivation and output of EGF. VIP in a dose of 3 X 10(-11) to 3 X 10(-10) mol/kg per h enhanced the stimulatory effect of acetylcholine, but this effect disappeared when the dose of VIP was increased. Adrenalectomy decreased acetylcholine stimulated total output of EGF by approximately 50%, but only by 20% when acetylcholine plus VIP was administered. EGF was localized to the convoluted granular tubules in the submandibular gland, whereas EGF could not be detected in the remaining salivary glands. The results suggest that VIP and acetylcholine cooperate in the control of exocrine secretion from the rat salivary glands. The effect of acetylcholine, however, seems to be partly dependent on circulating catecholamines.

KW - Acetylcholine

KW - Animals

KW - Dose-Response Relationship, Drug

KW - Epidermal Growth Factor

KW - Male

KW - Rats

KW - Rats, Inbred Strains

KW - Saliva

KW - Submandibular Gland

KW - Vasoactive Intestinal Peptide

M3 - Journal article

C2 - 3489957

VL - 15

SP - 37

EP - 46

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 1

ER -

ID: 47488857