Ultrastructure of interstitial cells of Cajal in circular muscle of human small intestine

Research output: Contribution to journal › Journal article › Research › peer-review

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Ultrastructure of interstitial cells of Cajal in circular muscle of human small intestine. / Rumessen, J J; Mikkelsen, H B; Qvortrup, K; Thuneberg, L.

In: Gastroenterology, Vol. 104, No. 2, 02.1993, p. 343-50.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rumessen, JJ, Mikkelsen, HB, Qvortrup, K & Thuneberg, L 1993, 'Ultrastructure of interstitial cells of Cajal in circular muscle of human small intestine', Gastroenterology, vol. 104, no. 2, pp. 343-50.

APA

Rumessen, J. J., Mikkelsen, H. B., Qvortrup, K., & Thuneberg, L. (1993). Ultrastructure of interstitial cells of Cajal in circular muscle of human small intestine. Gastroenterology, 104(2), 343-50.

Vancouver

Rumessen JJ, Mikkelsen HB, Qvortrup K, Thuneberg L. Ultrastructure of interstitial cells of Cajal in circular muscle of human small intestine. Gastroenterology. 1993 Feb;104(2):343-50.

Author

Rumessen, J J ; Mikkelsen, H B ; Qvortrup, K ; Thuneberg, L. / Ultrastructure of interstitial cells of Cajal in circular muscle of human small intestine. In: Gastroenterology. 1993 ; Vol. 104, No. 2. pp. 343-50.

Bibtex

@article{6283da1d86004cc8acde95349a110ab1,
title = "Ultrastructure of interstitial cells of Cajal in circular muscle of human small intestine",
abstract = "BACKGROUND: Interstitial cells of Cajal (ICC) may be important regulatory cells in gut muscle layers. This study examined ICC within the circular muscle of human small intestine.METHODS: Surgically resected, uninvolved intestine was studied by light microscopy and electron microscopy.RESULTS: Muscle lamellae were separated by main septa in continuity with submucosa. Smooth muscle cells ran radially in the septa. Two types of ICC were distinguished. One ICC type had abundant intermediate filaments and smooth cisternae and a discontinuous basal lamina. This ICC type was present in the septa and in the outer third of the circular lamellae. The other ICC type had a complete basal lamina and conspicuous caveolae. This ICC type was observed only in the inner third of the circular lamellae. Both ICC types were close to nerves, but only the latter type formed gap junctions with one another and with muscle cells. Junctions between the two ICC types were not observed.CONCLUSIONS: The arrangement suggests that ICC and radially oriented muscle cells participate in electrical and mechanical coordination of the circular muscle layer of human small intestine.",
keywords = "Adult, Aged, Aged, 80 and over, Female, Humans, Intercellular Junctions, Intestine, Small, Male, Middle Aged, Muscle, Smooth, Journal Article, Research Support, Non-U.S. Gov't",
author = "Rumessen, {J J} and Mikkelsen, {H B} and K Qvortrup and L Thuneberg",
year = "1993",
month = feb,
language = "English",
volume = "104",
pages = "343--50",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Ultrastructure of interstitial cells of Cajal in circular muscle of human small intestine

AU - Rumessen, J J

AU - Mikkelsen, H B

AU - Qvortrup, K

AU - Thuneberg, L

PY - 1993/2

Y1 - 1993/2

N2 - BACKGROUND: Interstitial cells of Cajal (ICC) may be important regulatory cells in gut muscle layers. This study examined ICC within the circular muscle of human small intestine.METHODS: Surgically resected, uninvolved intestine was studied by light microscopy and electron microscopy.RESULTS: Muscle lamellae were separated by main septa in continuity with submucosa. Smooth muscle cells ran radially in the septa. Two types of ICC were distinguished. One ICC type had abundant intermediate filaments and smooth cisternae and a discontinuous basal lamina. This ICC type was present in the septa and in the outer third of the circular lamellae. The other ICC type had a complete basal lamina and conspicuous caveolae. This ICC type was observed only in the inner third of the circular lamellae. Both ICC types were close to nerves, but only the latter type formed gap junctions with one another and with muscle cells. Junctions between the two ICC types were not observed.CONCLUSIONS: The arrangement suggests that ICC and radially oriented muscle cells participate in electrical and mechanical coordination of the circular muscle layer of human small intestine.

AB - BACKGROUND: Interstitial cells of Cajal (ICC) may be important regulatory cells in gut muscle layers. This study examined ICC within the circular muscle of human small intestine.METHODS: Surgically resected, uninvolved intestine was studied by light microscopy and electron microscopy.RESULTS: Muscle lamellae were separated by main septa in continuity with submucosa. Smooth muscle cells ran radially in the septa. Two types of ICC were distinguished. One ICC type had abundant intermediate filaments and smooth cisternae and a discontinuous basal lamina. This ICC type was present in the septa and in the outer third of the circular lamellae. The other ICC type had a complete basal lamina and conspicuous caveolae. This ICC type was observed only in the inner third of the circular lamellae. Both ICC types were close to nerves, but only the latter type formed gap junctions with one another and with muscle cells. Junctions between the two ICC types were not observed.CONCLUSIONS: The arrangement suggests that ICC and radially oriented muscle cells participate in electrical and mechanical coordination of the circular muscle layer of human small intestine.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Female

KW - Humans

KW - Intercellular Junctions

KW - Intestine, Small

KW - Male

KW - Middle Aged

KW - Muscle, Smooth

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Journal article

C2 - 8425676

VL - 104

SP - 343

EP - 350

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 2

ER -

ID: 176771226