Trefoil factor family peptides in the human foetus and at birth
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Trefoil factor family peptides in the human foetus and at birth. / Samson, Mie Hessellund; Poulsen, Steen Seier; Obeid, Rima; Herrmann, Wolfgang; Nexo, Ebba.
In: European Journal of Clinical Investigation, Vol. 41, No. 7, 01.07.2011, p. 785-792.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Trefoil factor family peptides in the human foetus and at birth
AU - Samson, Mie Hessellund
AU - Poulsen, Steen Seier
AU - Obeid, Rima
AU - Herrmann, Wolfgang
AU - Nexo, Ebba
N1 - © 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Eur J Clin Invest 2011; 41 (7): 785-792 ABSTRACT: Background Trefoil factors (TFF1-3) are cysteine-rich peptides secreted by mucosal surfaces. Changing levels of expression are reflected in serum concentrations. Serum levels of TFF2 and TFF3 are highly elevated during pregnancy. Here, we explore a possible foetal origin of these increased levels. Materials and methods We examined the expression of trefoil peptides in foetal tissues, placentas and foetal membranes from midterm abortions by immunohistochemistry. Employing in-house ELISAs, serum concentrations of TFF1-3 were measured in 92 paired samples of cord and maternal blood prior to delivery. Size exclusion chromatography was used to investigate the molecular forms of TFF1-3. Results Immunohistochemistry showed all trefoil peptides to be present during foetal life, but compared to adults with a more widespread expression of TFF2 and TFF3 in the stomach and Brunner's glands. No trefoil peptides were seen in placentas or foetal membranes. Median serum concentrations of TFF1 in cord blood were comparable to those observed in the (mother) [0·42 (0·37) nM, P = 0·25], whereas TFF2 and TFF3 showed lower values than in the mother [0·11 (0·69), and 1·2 (6·7) nM, respectively, P
AB - Eur J Clin Invest 2011; 41 (7): 785-792 ABSTRACT: Background Trefoil factors (TFF1-3) are cysteine-rich peptides secreted by mucosal surfaces. Changing levels of expression are reflected in serum concentrations. Serum levels of TFF2 and TFF3 are highly elevated during pregnancy. Here, we explore a possible foetal origin of these increased levels. Materials and methods We examined the expression of trefoil peptides in foetal tissues, placentas and foetal membranes from midterm abortions by immunohistochemistry. Employing in-house ELISAs, serum concentrations of TFF1-3 were measured in 92 paired samples of cord and maternal blood prior to delivery. Size exclusion chromatography was used to investigate the molecular forms of TFF1-3. Results Immunohistochemistry showed all trefoil peptides to be present during foetal life, but compared to adults with a more widespread expression of TFF2 and TFF3 in the stomach and Brunner's glands. No trefoil peptides were seen in placentas or foetal membranes. Median serum concentrations of TFF1 in cord blood were comparable to those observed in the (mother) [0·42 (0·37) nM, P = 0·25], whereas TFF2 and TFF3 showed lower values than in the mother [0·11 (0·69), and 1·2 (6·7) nM, respectively, P
U2 - 10.1111/j.1365-2362.2011.02489.x
DO - 10.1111/j.1365-2362.2011.02489.x
M3 - Journal article
C2 - 21651517
VL - 41
SP - 785
EP - 792
JO - Zeitschrift fur klinische Medizin
JF - Zeitschrift fur klinische Medizin
SN - 0014-2972
IS - 7
ER -
ID: 33792271