Translational implications of bradyarrhythmia in hibernating brown bears
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The brown bear Ursus arctos undergoes exceptional physiological adaptions during annual hibernation that minimize energy consumption, including profound decrease in heart rate, cardiac output, and respiratory rate. These changes are completely reversible after the bears reenter into the active state in spring. In this case report, we show episodes of sinus arrest in a hibernating Scandinavian brown bear and in humans, recorded by implantable loop recorders and discuss the possible underlying mechanisms. Lessons learned from cardiac adaptations in hibernating bears might prove useful in the treatment of patients with sinus node dysfunction.
Original language | English |
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Article number | e15550 |
Journal | Physiological Reports |
Volume | 11 |
Issue number | 1 |
Number of pages | 6 |
ISSN | 2051-817X |
DOIs | |
Publication status | Published - 2023 |
Bibliographical note
Publisher Copyright:
© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.
- Ursus arctos, bradyarrhythmia, brown bear, hibernation, sinus arrest, sinus node disease, sinus pause, syncope, translational model
Research areas
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