Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes. / Suri, Bani Kaur; Verma, Navin Kumar; Schmidtchen, Artur.

In: Acta Dermato-Venereologica, Vol. 98, No. 8, 2018, p. 762-765.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Suri, BK, Verma, NK & Schmidtchen, A 2018, 'Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes', Acta Dermato-Venereologica, vol. 98, no. 8, pp. 762-765. https://doi.org/10.2340/00015555-2963

APA

Suri, B. K., Verma, N. K., & Schmidtchen, A. (2018). Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes. Acta Dermato-Venereologica, 98(8), 762-765. https://doi.org/10.2340/00015555-2963

Vancouver

Suri BK, Verma NK, Schmidtchen A. Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes. Acta Dermato-Venereologica. 2018;98(8):762-765. https://doi.org/10.2340/00015555-2963

Author

Suri, Bani Kaur ; Verma, Navin Kumar ; Schmidtchen, Artur. / Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes. In: Acta Dermato-Venereologica. 2018 ; Vol. 98, No. 8. pp. 762-765.

Bibtex

@article{d784cde8691040df8a05be4d53716793,
title = "Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes",
abstract = "Carbonic anhydrases are ubiquitously expressed enzymes that reversibly hydrate carbon dioxide to bicarbonate and protons. While the main function of carbonic anhydrases is to regulate pH and osmotic balance, their involvement in other physiological processes remains to be explored. This study analysed changes in mRNA and protein levels of carbonic anhydrase II in human primary keratinocytes treated with various toll-like receptor agonists and cytokines. A significant upregulation of carbonic anhydrase II at the mRNA and protein levels was observed upon treatment with polyinosinic-polycytidylic acid, a toll-like receptor 3 agonist. Furthermore, in agreement with the increased expression of carbonic anhydrase II in atopic dermatitis skin, carbonic anhydrase II was upregulated by the Th2 cytokines interleukins-4 and-13. In conclusion, these results suggest a potential role of carbonic anhydrase II in Th2-dependent and toll-like receptor 3-induced pathways in inflammatory skin conditions.",
keywords = "carbonic anhydrase II, keratinocytes, TLR3, poly(I:C), Th2 cytokines, inflammation",
author = "Suri, {Bani Kaur} and Verma, {Navin Kumar} and Artur Schmidtchen",
year = "2018",
doi = "10.2340/00015555-2963",
language = "English",
volume = "98",
pages = "762--765",
journal = "Acta Dermato-Venereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",
number = "8",

}

RIS

TY - JOUR

T1 - Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes

AU - Suri, Bani Kaur

AU - Verma, Navin Kumar

AU - Schmidtchen, Artur

PY - 2018

Y1 - 2018

N2 - Carbonic anhydrases are ubiquitously expressed enzymes that reversibly hydrate carbon dioxide to bicarbonate and protons. While the main function of carbonic anhydrases is to regulate pH and osmotic balance, their involvement in other physiological processes remains to be explored. This study analysed changes in mRNA and protein levels of carbonic anhydrase II in human primary keratinocytes treated with various toll-like receptor agonists and cytokines. A significant upregulation of carbonic anhydrase II at the mRNA and protein levels was observed upon treatment with polyinosinic-polycytidylic acid, a toll-like receptor 3 agonist. Furthermore, in agreement with the increased expression of carbonic anhydrase II in atopic dermatitis skin, carbonic anhydrase II was upregulated by the Th2 cytokines interleukins-4 and-13. In conclusion, these results suggest a potential role of carbonic anhydrase II in Th2-dependent and toll-like receptor 3-induced pathways in inflammatory skin conditions.

AB - Carbonic anhydrases are ubiquitously expressed enzymes that reversibly hydrate carbon dioxide to bicarbonate and protons. While the main function of carbonic anhydrases is to regulate pH and osmotic balance, their involvement in other physiological processes remains to be explored. This study analysed changes in mRNA and protein levels of carbonic anhydrase II in human primary keratinocytes treated with various toll-like receptor agonists and cytokines. A significant upregulation of carbonic anhydrase II at the mRNA and protein levels was observed upon treatment with polyinosinic-polycytidylic acid, a toll-like receptor 3 agonist. Furthermore, in agreement with the increased expression of carbonic anhydrase II in atopic dermatitis skin, carbonic anhydrase II was upregulated by the Th2 cytokines interleukins-4 and-13. In conclusion, these results suggest a potential role of carbonic anhydrase II in Th2-dependent and toll-like receptor 3-induced pathways in inflammatory skin conditions.

KW - carbonic anhydrase II

KW - keratinocytes

KW - TLR3

KW - poly(I:C)

KW - Th2 cytokines

KW - inflammation

U2 - 10.2340/00015555-2963

DO - 10.2340/00015555-2963

M3 - Journal article

C2 - 29738048

VL - 98

SP - 762

EP - 765

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 8

ER -

ID: 212851600