The significance of left ventricular ejection time in heart failure with reduced ejection fraction

Research output: Contribution to journal › Review › Research › peer-review

Standard

The significance of left ventricular ejection time in heart failure with reduced ejection fraction. / Alhakak, Alia S.; Teerlink, John R.; Lindenfeld, Joann; Boehm, Michael; Rosano, Giuseppe M. C.; Biering-Sorensen, Tor.

In: European Journal of Heart Failure, Vol. 23, No. 4, 2021, p. 541-551.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Alhakak, AS, Teerlink, JR, Lindenfeld, J, Boehm, M, Rosano, GMC & Biering-Sorensen, T 2021, 'The significance of left ventricular ejection time in heart failure with reduced ejection fraction', European Journal of Heart Failure, vol. 23, no. 4, pp. 541-551. https://doi.org/10.1002/ejhf.2125

APA

Alhakak, A. S., Teerlink, J. R., Lindenfeld, J., Boehm, M., Rosano, G. M. C., & Biering-Sorensen, T. (2021). The significance of left ventricular ejection time in heart failure with reduced ejection fraction. European Journal of Heart Failure, 23(4), 541-551. https://doi.org/10.1002/ejhf.2125

Vancouver

Alhakak AS, Teerlink JR, Lindenfeld J, Boehm M, Rosano GMC, Biering-Sorensen T. The significance of left ventricular ejection time in heart failure with reduced ejection fraction. European Journal of Heart Failure. 2021;23(4):541-551. https://doi.org/10.1002/ejhf.2125

Author

Alhakak, Alia S. ; Teerlink, John R. ; Lindenfeld, Joann ; Boehm, Michael ; Rosano, Giuseppe M. C. ; Biering-Sorensen, Tor. / The significance of left ventricular ejection time in heart failure with reduced ejection fraction. In: European Journal of Heart Failure. 2021 ; Vol. 23, No. 4. pp. 541-551.

Bibtex

@article{9f1333ac1ac449d39097c454a8eb0f07,
title = "The significance of left ventricular ejection time in heart failure with reduced ejection fraction",
abstract = "Left ventricular ejection time (LVET) is defined as the time interval from aortic valve opening to aortic valve closure, and is the phase of systole during which the left ventricle ejects blood into the aorta. LVET has been used for several decades to assess left ventricular function and contractility. However, there is a recent interest in LVET as a measure of therapeutic action for novel drugs in patients with heart failure with reduced ejection fraction (HFrEF), since LVET is shortened in these patients. This review provides an overview of the available information on LVET including methods of measuring LVET, mechanistic understanding of LVET, association of LVET with outcomes, mechanisms behind shortened LVET in HFrEF and the potential implications of drugs that affect and normalize LVET.[GRAPHICS]",
keywords = "Left ventricular ejection time, Heart failure, Myotropes, Contractility, Outcomes, CARDIAC MYOSIN ACTIVATOR, MYOCARDIAL PERFORMANCE INDEX, M-MODE ECHOCARDIOGRAPHY, IMAGING M-MODE, OMECAMTIV MECARBIL, INCREASE CONTRACTILITY, INTERVALS, MECHANISMS, RISK, CARVEDILOL",
author = "Alhakak, {Alia S.} and Teerlink, {John R.} and Joann Lindenfeld and Michael Boehm and Rosano, {Giuseppe M. C.} and Tor Biering-Sorensen",
year = "2021",
doi = "10.1002/ejhf.2125",
language = "English",
volume = "23",
pages = "541--551",
journal = "European Journal of Heart Failure",
issn = "1567-4215",
publisher = "JohnWiley & Sons Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - The significance of left ventricular ejection time in heart failure with reduced ejection fraction

AU - Alhakak, Alia S.

AU - Teerlink, John R.

AU - Lindenfeld, Joann

AU - Boehm, Michael

AU - Rosano, Giuseppe M. C.

AU - Biering-Sorensen, Tor

PY - 2021

Y1 - 2021

N2 - Left ventricular ejection time (LVET) is defined as the time interval from aortic valve opening to aortic valve closure, and is the phase of systole during which the left ventricle ejects blood into the aorta. LVET has been used for several decades to assess left ventricular function and contractility. However, there is a recent interest in LVET as a measure of therapeutic action for novel drugs in patients with heart failure with reduced ejection fraction (HFrEF), since LVET is shortened in these patients. This review provides an overview of the available information on LVET including methods of measuring LVET, mechanistic understanding of LVET, association of LVET with outcomes, mechanisms behind shortened LVET in HFrEF and the potential implications of drugs that affect and normalize LVET.[GRAPHICS]

AB - Left ventricular ejection time (LVET) is defined as the time interval from aortic valve opening to aortic valve closure, and is the phase of systole during which the left ventricle ejects blood into the aorta. LVET has been used for several decades to assess left ventricular function and contractility. However, there is a recent interest in LVET as a measure of therapeutic action for novel drugs in patients with heart failure with reduced ejection fraction (HFrEF), since LVET is shortened in these patients. This review provides an overview of the available information on LVET including methods of measuring LVET, mechanistic understanding of LVET, association of LVET with outcomes, mechanisms behind shortened LVET in HFrEF and the potential implications of drugs that affect and normalize LVET.[GRAPHICS]

KW - Left ventricular ejection time

KW - Heart failure

KW - Myotropes

KW - Contractility

KW - Outcomes

KW - CARDIAC MYOSIN ACTIVATOR

KW - MYOCARDIAL PERFORMANCE INDEX

KW - M-MODE ECHOCARDIOGRAPHY

KW - IMAGING M-MODE

KW - OMECAMTIV MECARBIL

KW - INCREASE CONTRACTILITY

KW - INTERVALS

KW - MECHANISMS

KW - RISK

KW - CARVEDILOL

U2 - 10.1002/ejhf.2125

DO - 10.1002/ejhf.2125

M3 - Review

C2 - 33590579

VL - 23

SP - 541

EP - 551

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

SN - 1567-4215

IS - 4

ER -

ID: 274278065