The role of hypothiocyanous acid (HOSCN) in biological systems

Research output: Contribution to journalJournal articleCommissionedpeer-review

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The role of hypothiocyanous acid (HOSCN) in biological systems. / Hawkins, Clare L.

In: Free Radical Research, Vol. 43, No. 12, 12.2009, p. 1147-58.

Research output: Contribution to journalJournal articleCommissionedpeer-review

Harvard

Hawkins, CL 2009, 'The role of hypothiocyanous acid (HOSCN) in biological systems', Free Radical Research, vol. 43, no. 12, pp. 1147-58.

APA

Hawkins, C. L. (2009). The role of hypothiocyanous acid (HOSCN) in biological systems. Free Radical Research, 43(12), 1147-58.

Vancouver

Hawkins CL. The role of hypothiocyanous acid (HOSCN) in biological systems. Free Radical Research. 2009 Dec;43(12):1147-58.

Author

Hawkins, Clare L. / The role of hypothiocyanous acid (HOSCN) in biological systems. In: Free Radical Research. 2009 ; Vol. 43, No. 12. pp. 1147-58.

Bibtex

@article{e92bfd58582c47cea79844d777692229,
title = "The role of hypothiocyanous acid (HOSCN) in biological systems",
abstract = "Hypohalous acids (HOX), produced by peroxidase-catalysed reactions of halide and pseudohalide ions with H(2)O(2), play an important role in the human immune system. However, there is compelling evidence that these oxidants also mediate host tissue damage and contribute to the progression of a number of inflammatory diseases. Although it is well established that significant amounts of hypothiocyanous acid (HOSCN) are formed under physiological conditions, the reactions of this oxidant with host biological systems are relatively poorly characterized. It is generally accepted that HOSCN is a mild oxidant that reacts selectively with thiols. However, it is becoming increasingly recognized that this selectivity can result in the induction of significant cellular damage, which may contribute to disease. This review will outline the formation and reactivity of HOSCN and the role of this oxidant in biological systems.",
keywords = "Animals, Apoptosis, Humans, Oxidants, Oxidative Stress, Thiocyanates, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Hawkins, {Clare L}",
year = "2009",
month = "12",
language = "English",
volume = "43",
pages = "1147--58",
journal = "Free Radical Research",
issn = "1071-5762",
publisher = "Taylor & Francis",
number = "12",

}

RIS

TY - JOUR

T1 - The role of hypothiocyanous acid (HOSCN) in biological systems

AU - Hawkins, Clare L

PY - 2009/12

Y1 - 2009/12

N2 - Hypohalous acids (HOX), produced by peroxidase-catalysed reactions of halide and pseudohalide ions with H(2)O(2), play an important role in the human immune system. However, there is compelling evidence that these oxidants also mediate host tissue damage and contribute to the progression of a number of inflammatory diseases. Although it is well established that significant amounts of hypothiocyanous acid (HOSCN) are formed under physiological conditions, the reactions of this oxidant with host biological systems are relatively poorly characterized. It is generally accepted that HOSCN is a mild oxidant that reacts selectively with thiols. However, it is becoming increasingly recognized that this selectivity can result in the induction of significant cellular damage, which may contribute to disease. This review will outline the formation and reactivity of HOSCN and the role of this oxidant in biological systems.

AB - Hypohalous acids (HOX), produced by peroxidase-catalysed reactions of halide and pseudohalide ions with H(2)O(2), play an important role in the human immune system. However, there is compelling evidence that these oxidants also mediate host tissue damage and contribute to the progression of a number of inflammatory diseases. Although it is well established that significant amounts of hypothiocyanous acid (HOSCN) are formed under physiological conditions, the reactions of this oxidant with host biological systems are relatively poorly characterized. It is generally accepted that HOSCN is a mild oxidant that reacts selectively with thiols. However, it is becoming increasingly recognized that this selectivity can result in the induction of significant cellular damage, which may contribute to disease. This review will outline the formation and reactivity of HOSCN and the role of this oxidant in biological systems.

KW - Animals

KW - Apoptosis

KW - Humans

KW - Oxidants

KW - Oxidative Stress

KW - Thiocyanates

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

M3 - Journal article

C2 - 19905977

VL - 43

SP - 1147

EP - 1158

JO - Free Radical Research

JF - Free Radical Research

SN - 1071-5762

IS - 12

ER -

ID: 174497579