The relationship between coronary artery calcium and layer-specific global longitudinal strain in patients with suspected coronary artery disease
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
The relationship between coronary artery calcium and layer-specific global longitudinal strain in patients with suspected coronary artery disease. / Frimodt-Møller, Emilie Katrine; Olsen, Flemming Javier; Lassen, Mats Christian Højbjerg; Skaarup, Kristoffer Grundtvig; Brainin, Philip; Bech, Jan; Folke, Frederik; Fritz-Hansen, Thomas; Gislason, Gunnar; Biering-Sørensen, Tor.
In: Echocardiography, Vol. 41, No. 2, e15775, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The relationship between coronary artery calcium and layer-specific global longitudinal strain in patients with suspected coronary artery disease
AU - Frimodt-Møller, Emilie Katrine
AU - Olsen, Flemming Javier
AU - Lassen, Mats Christian Højbjerg
AU - Skaarup, Kristoffer Grundtvig
AU - Brainin, Philip
AU - Bech, Jan
AU - Folke, Frederik
AU - Fritz-Hansen, Thomas
AU - Gislason, Gunnar
AU - Biering-Sørensen, Tor
N1 - Publisher Copyright: © 2024 Wiley Periodicals LLC.
PY - 2024
Y1 - 2024
N2 - Purpose: Layer-specific global longitudinal strain (GLS) may provide important insights in patients with suspected coronary artery disease (CAD). We aimed to investigate the association between layer-specific GLS and coronary artery calcium score (CACS) in patients suspected of CAD. Methods: We performed a retrospective study of patients suspected of CAD who underwent both an echocardiogram and cardiac computed tomography (median 42 days between). Layer-specific (endocardial-, whole-layer-, and epicardial-) GLS was measured using speckle tracking echocardiography. We assessed the continuous association between layer-specific GLS and CACS by negative binomial regression, and the association with high CACS (≥400) using logistic regression. Results: Of the 496 patients included (mean age 59 years, 56% male), 64 (13%) had a high CACS. Those with high CACS had reduced GLS in all layers compared to those with CACS < 400 (endocardial GLS: −20.5 vs. −22.7%, whole-layer GLS: −17.7 vs. −19.4%, epicardial GLS: −15.3 vs. −16.9%, p <.001 for all). Negative binomial regression revealed a significant continuous association showing increasing CACS with worsening GLS in all layers, which remained significant after multivariable adjustment including SCORE chart risk factors. All layers of GLS were associated with high CACS in univariable analyses, which was consistent after multivariable adjustment (endocardial GLS: OR = 1.11 (1.03–1.20); whole-layer GLS: OR = 1.14 (1.04–1.24); epicardial GLS: OR = 1.16 (1.05–1.29), per 1% absolute decrease). Conclusion: In this study population with patients suspected of CAD and normal systolic function, impaired layer-specific GLS was continuously associated with increasing CACS, and decreasing GLS in all layers were associated with presence of high CACS.
AB - Purpose: Layer-specific global longitudinal strain (GLS) may provide important insights in patients with suspected coronary artery disease (CAD). We aimed to investigate the association between layer-specific GLS and coronary artery calcium score (CACS) in patients suspected of CAD. Methods: We performed a retrospective study of patients suspected of CAD who underwent both an echocardiogram and cardiac computed tomography (median 42 days between). Layer-specific (endocardial-, whole-layer-, and epicardial-) GLS was measured using speckle tracking echocardiography. We assessed the continuous association between layer-specific GLS and CACS by negative binomial regression, and the association with high CACS (≥400) using logistic regression. Results: Of the 496 patients included (mean age 59 years, 56% male), 64 (13%) had a high CACS. Those with high CACS had reduced GLS in all layers compared to those with CACS < 400 (endocardial GLS: −20.5 vs. −22.7%, whole-layer GLS: −17.7 vs. −19.4%, epicardial GLS: −15.3 vs. −16.9%, p <.001 for all). Negative binomial regression revealed a significant continuous association showing increasing CACS with worsening GLS in all layers, which remained significant after multivariable adjustment including SCORE chart risk factors. All layers of GLS were associated with high CACS in univariable analyses, which was consistent after multivariable adjustment (endocardial GLS: OR = 1.11 (1.03–1.20); whole-layer GLS: OR = 1.14 (1.04–1.24); epicardial GLS: OR = 1.16 (1.05–1.29), per 1% absolute decrease). Conclusion: In this study population with patients suspected of CAD and normal systolic function, impaired layer-specific GLS was continuously associated with increasing CACS, and decreasing GLS in all layers were associated with presence of high CACS.
KW - cardiac computed tomography
KW - coronary artery calcium
KW - coronary artery disease
KW - layered-specific global longitudinal strain
U2 - 10.1111/echo.15775
DO - 10.1111/echo.15775
M3 - Journal article
C2 - 38353468
AN - SCOPUS:85185135793
VL - 41
JO - Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques
JF - Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques
SN - 0742-2822
IS - 2
M1 - e15775
ER -
ID: 384410605