The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling

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The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling. / Benned-Jensen, Tau; Mokrosinski, Jacek; Rosenkilde, Mette M.

In: P L o S One, Vol. 6, No. 9, 2011, p. e24644.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Benned-Jensen, T, Mokrosinski, J & Rosenkilde, MM 2011, 'The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling', P L o S One, vol. 6, no. 9, pp. e24644. https://doi.org/10.1371/journal.pone.0024644

APA

Benned-Jensen, T., Mokrosinski, J., & Rosenkilde, M. M. (2011). The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling. P L o S One, 6(9), e24644. https://doi.org/10.1371/journal.pone.0024644

Vancouver

Benned-Jensen T, Mokrosinski J, Rosenkilde MM. The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling. P L o S One. 2011;6(9):e24644. https://doi.org/10.1371/journal.pone.0024644

Author

Benned-Jensen, Tau ; Mokrosinski, Jacek ; Rosenkilde, Mette M. / The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling. In: P L o S One. 2011 ; Vol. 6, No. 9. pp. e24644.

Bibtex

@article{f1c20971558145e399b2d1d073d01a00,
title = "The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling",
abstract = "The melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution found at position II:20/2.60 in the top of transmembrane helix II which has been identified in melanic mice and several other species. This mutation induces a pronounced increase in MC1R constitutive activity suggesting a link between constitutive activity and melanism which is corroborated by the attenuation of a-melanocyte stimulating hormone (aMSH) induced activation. However, the mechanism by which the mutation induces constitutive activity is currently not known.",
keywords = "Animals, Arrestin, Cell Line, Cyclic AMP, Enzyme-Linked Immunosorbent Assay, Extracellular Signal-Regulated MAP Kinases, Humans, Mice, Microscopy, Confocal, Mutagenesis, Site-Directed, Mutation, Phosphorylation, Receptor, Melanocortin, Type 1, Signal Transduction, alpha-MSH",
author = "Tau Benned-Jensen and Jacek Mokrosinski and Rosenkilde, {Mette M}",
year = "2011",
doi = "10.1371/journal.pone.0024644",
language = "English",
volume = "6",
pages = "e24644",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling

AU - Benned-Jensen, Tau

AU - Mokrosinski, Jacek

AU - Rosenkilde, Mette M

PY - 2011

Y1 - 2011

N2 - The melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution found at position II:20/2.60 in the top of transmembrane helix II which has been identified in melanic mice and several other species. This mutation induces a pronounced increase in MC1R constitutive activity suggesting a link between constitutive activity and melanism which is corroborated by the attenuation of a-melanocyte stimulating hormone (aMSH) induced activation. However, the mechanism by which the mutation induces constitutive activity is currently not known.

AB - The melanocortin 1 receptor (MC1R) constitutes a key regulator of melanism. Consequently, many naturally-occurring MC1R mutations are associated with a change in color. An example is the Glu-to-Lys substitution found at position II:20/2.60 in the top of transmembrane helix II which has been identified in melanic mice and several other species. This mutation induces a pronounced increase in MC1R constitutive activity suggesting a link between constitutive activity and melanism which is corroborated by the attenuation of a-melanocyte stimulating hormone (aMSH) induced activation. However, the mechanism by which the mutation induces constitutive activity is currently not known.

KW - Animals

KW - Arrestin

KW - Cell Line

KW - Cyclic AMP

KW - Enzyme-Linked Immunosorbent Assay

KW - Extracellular Signal-Regulated MAP Kinases

KW - Humans

KW - Mice

KW - Microscopy, Confocal

KW - Mutagenesis, Site-Directed

KW - Mutation

KW - Phosphorylation

KW - Receptor, Melanocortin, Type 1

KW - Signal Transduction

KW - alpha-MSH

U2 - 10.1371/journal.pone.0024644

DO - 10.1371/journal.pone.0024644

M3 - Journal article

C2 - 21931793

VL - 6

SP - e24644

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 9

ER -

ID: 38463832