The Combination of In vivo (124)I-PET and CT Small Animal Imaging for Evaluation of Thyroid Physiology and Dosimetry
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The Combination of In vivo (124)I-PET and CT Small Animal Imaging for Evaluation of Thyroid Physiology and Dosimetry. / El-Ali, Henrik H; Eckerwall, Martin; Skovgaard, Dorthe; Larsson, Erik; Strand, Sven-Erik; Kjaer, Andreas.
In: Diagnostics, Vol. 2, No. 2, 2012, p. 10-22.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The Combination of In vivo (124)I-PET and CT Small Animal Imaging for Evaluation of Thyroid Physiology and Dosimetry
AU - El-Ali, Henrik H
AU - Eckerwall, Martin
AU - Skovgaard, Dorthe
AU - Larsson, Erik
AU - Strand, Sven-Erik
AU - Kjaer, Andreas
PY - 2012
Y1 - 2012
N2 - OBJECTIVE: A thyroid rat model combining functional and anatomical information would be of great benefit for better modeling of thyroid physiology and for absorbed dose calculations. Our aim was to show that (124)I-PET and CT small animal imaging are useful as a combined model for studying thyroid physiology and dose calculation.METHODS: Seven rats were subjects for multiple thyroid (124)I-imaging and CT-scans. S-values [mGy/MBqs] for different thyroid sizes were simulated. A phantom with spheres was designed for validation of performances of the small animal PET and CT imaging systems.RESULTS: Small animal image-based measurements of the activity amount and the volumes of the spheres with a priori known volumes showed a good agreement with their corresponding actual volumes. The CT scans of the rats showed thyroid volumes from 34-70 mL.CONCLUSIONS: The wide span in volumes of thyroid glands indicates the importance of using an accurate volume-measuring technique such as the small animal CT. The small animal PET system was on the other hand able to accurately estimate the activity concentration in the thyroid volumes. We conclude that the combination of the PET and CT image information is essential for quantitative thyroid imaging and accurate thyroid absorbed dose calculation.
AB - OBJECTIVE: A thyroid rat model combining functional and anatomical information would be of great benefit for better modeling of thyroid physiology and for absorbed dose calculations. Our aim was to show that (124)I-PET and CT small animal imaging are useful as a combined model for studying thyroid physiology and dose calculation.METHODS: Seven rats were subjects for multiple thyroid (124)I-imaging and CT-scans. S-values [mGy/MBqs] for different thyroid sizes were simulated. A phantom with spheres was designed for validation of performances of the small animal PET and CT imaging systems.RESULTS: Small animal image-based measurements of the activity amount and the volumes of the spheres with a priori known volumes showed a good agreement with their corresponding actual volumes. The CT scans of the rats showed thyroid volumes from 34-70 mL.CONCLUSIONS: The wide span in volumes of thyroid glands indicates the importance of using an accurate volume-measuring technique such as the small animal CT. The small animal PET system was on the other hand able to accurately estimate the activity concentration in the thyroid volumes. We conclude that the combination of the PET and CT image information is essential for quantitative thyroid imaging and accurate thyroid absorbed dose calculation.
U2 - 10.3390/diagnostics2020010
DO - 10.3390/diagnostics2020010
M3 - Journal article
C2 - 26859394
VL - 2
SP - 10
EP - 22
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 2
ER -
ID: 156848956