Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors

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Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors. / Rosenkilde, M M; Smit, M J; Waldhoer, M.

In: British Journal of Pharmacology, Vol. 153 Suppl 1, 2008, p. S154-66.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rosenkilde, MM, Smit, MJ & Waldhoer, M 2008, 'Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors', British Journal of Pharmacology, vol. 153 Suppl 1, pp. S154-66. https://doi.org/10.1038/sj.bjp.0707660

APA

Rosenkilde, M. M., Smit, M. J., & Waldhoer, M. (2008). Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors. British Journal of Pharmacology, 153 Suppl 1, S154-66. https://doi.org/10.1038/sj.bjp.0707660

Vancouver

Rosenkilde MM, Smit MJ, Waldhoer M. Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors. British Journal of Pharmacology. 2008;153 Suppl 1:S154-66. https://doi.org/10.1038/sj.bjp.0707660

Author

Rosenkilde, M M ; Smit, M J ; Waldhoer, M. / Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors. In: British Journal of Pharmacology. 2008 ; Vol. 153 Suppl 1. pp. S154-66.

Bibtex

@article{7f646da0e61611ddbf70000ea68e967b,
title = "Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors",
abstract = "A number of human and animal herpes viruses encode G-protein coupled receptors with seven transmembrane (7TM) segments-most of which are clearly related to human chemokine receptors. It appears, that these receptors are used by the virus for immune evasion, cellular transformation, tissue targeting, and possibly for cell entry. In addition, many virally-encoded chemokine 7TM receptors have been suggested to be causally involved in pathogenic phenotypes like Kaposi sarcoma, atherosclerosis, HIV-infection and tumour development. The role of these receptors during the viral life cycle and in viral pathogenesis is still poorly understood. Here we focus on the current knowledge of structure, function and trafficking patterns of virally encoded chemokine receptors and further address the putative roles of these receptors in virus survival and host -cell and/or -immune system modulation. Finally, we highlight the emerging impact of these receptor on virus-mediated diseases.",
author = "Rosenkilde, {M M} and Smit, {M J} and M Waldhoer",
note = "Keywords: Animals; Humans; Receptors, CCR7; Rhodopsin; Structure-Activity Relationship; Virus Diseases; Viruses",
year = "2008",
doi = "10.1038/sj.bjp.0707660",
language = "English",
volume = "153 Suppl 1",
pages = "S154--66",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors

AU - Rosenkilde, M M

AU - Smit, M J

AU - Waldhoer, M

N1 - Keywords: Animals; Humans; Receptors, CCR7; Rhodopsin; Structure-Activity Relationship; Virus Diseases; Viruses

PY - 2008

Y1 - 2008

N2 - A number of human and animal herpes viruses encode G-protein coupled receptors with seven transmembrane (7TM) segments-most of which are clearly related to human chemokine receptors. It appears, that these receptors are used by the virus for immune evasion, cellular transformation, tissue targeting, and possibly for cell entry. In addition, many virally-encoded chemokine 7TM receptors have been suggested to be causally involved in pathogenic phenotypes like Kaposi sarcoma, atherosclerosis, HIV-infection and tumour development. The role of these receptors during the viral life cycle and in viral pathogenesis is still poorly understood. Here we focus on the current knowledge of structure, function and trafficking patterns of virally encoded chemokine receptors and further address the putative roles of these receptors in virus survival and host -cell and/or -immune system modulation. Finally, we highlight the emerging impact of these receptor on virus-mediated diseases.

AB - A number of human and animal herpes viruses encode G-protein coupled receptors with seven transmembrane (7TM) segments-most of which are clearly related to human chemokine receptors. It appears, that these receptors are used by the virus for immune evasion, cellular transformation, tissue targeting, and possibly for cell entry. In addition, many virally-encoded chemokine 7TM receptors have been suggested to be causally involved in pathogenic phenotypes like Kaposi sarcoma, atherosclerosis, HIV-infection and tumour development. The role of these receptors during the viral life cycle and in viral pathogenesis is still poorly understood. Here we focus on the current knowledge of structure, function and trafficking patterns of virally encoded chemokine receptors and further address the putative roles of these receptors in virus survival and host -cell and/or -immune system modulation. Finally, we highlight the emerging impact of these receptor on virus-mediated diseases.

U2 - 10.1038/sj.bjp.0707660

DO - 10.1038/sj.bjp.0707660

M3 - Journal article

C2 - 18204488

VL - 153 Suppl 1

SP - S154-66

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

ER -

ID: 9830891