Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.

Research output: Contribution to journalJournal articlepeer-review

Standard

Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. / Meier, Juris J; Gallwitz, Baptist; Kask, Bartholomaeus; Deacon, Carolyn F; Holst, Jens J; Schmidt, Wolfgang E; Nauck, Michael A.

In: Diabetes, Vol. 53 Suppl 3, 2004, p. S220-4.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Meier, JJ, Gallwitz, B, Kask, B, Deacon, CF, Holst, JJ, Schmidt, WE & Nauck, MA 2004, 'Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.', Diabetes, vol. 53 Suppl 3, pp. S220-4.

APA

Meier, J. J., Gallwitz, B., Kask, B., Deacon, C. F., Holst, J. J., Schmidt, W. E., & Nauck, M. A. (2004). Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. Diabetes, 53 Suppl 3, S220-4.

Vancouver

Meier JJ, Gallwitz B, Kask B, Deacon CF, Holst JJ, Schmidt WE et al. Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. Diabetes. 2004;53 Suppl 3:S220-4.

Author

Meier, Juris J ; Gallwitz, Baptist ; Kask, Bartholomaeus ; Deacon, Carolyn F ; Holst, Jens J ; Schmidt, Wolfgang E ; Nauck, Michael A. / Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects. In: Diabetes. 2004 ; Vol. 53 Suppl 3. pp. S220-4.

Bibtex

@article{dad82c40ab4b11ddb5e9000ea68e967b,
title = "Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.",
abstract = "A reduced insulinotropic effect of gastric inhibitory polypeptide (GIP) is a characteristic of patients with type 2 diabetes. It was the aim of this study to determine the response of insulin secretion to different GIP doses administered by intravenous bolus injection and via continuous infusion in both healthy subjects and patients with type 2 diabetes. Eight patients with type 2 diabetes and eight healthy subjects participated in a 240-min hyperglycemic clamp (140 mg/dl) with intravenous infusion of placebo, GIP at a low dose, and GIP at a high dose, each administered continuously over 60 min. Boluses of placebo, 20 pmol GIP/kg, and 80 pmol GIP/kg were injected intravenously at 0, 60, and 120 min, respectively. Capillary and venous blood was drawn for glucose, insulin, C-peptide, and GIP. Plasma insulin and C-peptide concentrations were lower in patients than in control subjects during all infusion periods. GIP bolus administration evoked a significant increase in plasma insulin levels in both patients with type 2 diabetes and healthy subjects. In contrast, the continuous GIP infusion led to a weak increase in insulin secretion in both healthy subjects and type 2 diabetic patients. The dose-response relationship for the increase in insulin secretion after GIP bolus administration was similar in both groups, although at different degrees of beta-cell function. The stimulation of insulin secretion by GIP is stronger after its bolus administration than during continuous infusion. Even though the insulin secretory capacity is generally impaired in patients with type 2 diabetes, the relative sensitivity of insulin secretion to a bolus administration of GIP is almost preserved. Therefore, the existence of a specific GIP receptor defect in type 2 diabetes appears unlikely.",
author = "Meier, {Juris J} and Baptist Gallwitz and Bartholomaeus Kask and Deacon, {Carolyn F} and Holst, {Jens J} and Schmidt, {Wolfgang E} and Nauck, {Michael A}",
note = "Keywords: Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Humans; Infusions, Intravenous; Injections, Intravenous; Insulin; Middle Aged; Reference Values",
year = "2004",
language = "English",
volume = "53 Suppl 3",
pages = "S220--4",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",

}

RIS

TY - JOUR

T1 - Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.

AU - Meier, Juris J

AU - Gallwitz, Baptist

AU - Kask, Bartholomaeus

AU - Deacon, Carolyn F

AU - Holst, Jens J

AU - Schmidt, Wolfgang E

AU - Nauck, Michael A

N1 - Keywords: Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Humans; Infusions, Intravenous; Injections, Intravenous; Insulin; Middle Aged; Reference Values

PY - 2004

Y1 - 2004

N2 - A reduced insulinotropic effect of gastric inhibitory polypeptide (GIP) is a characteristic of patients with type 2 diabetes. It was the aim of this study to determine the response of insulin secretion to different GIP doses administered by intravenous bolus injection and via continuous infusion in both healthy subjects and patients with type 2 diabetes. Eight patients with type 2 diabetes and eight healthy subjects participated in a 240-min hyperglycemic clamp (140 mg/dl) with intravenous infusion of placebo, GIP at a low dose, and GIP at a high dose, each administered continuously over 60 min. Boluses of placebo, 20 pmol GIP/kg, and 80 pmol GIP/kg were injected intravenously at 0, 60, and 120 min, respectively. Capillary and venous blood was drawn for glucose, insulin, C-peptide, and GIP. Plasma insulin and C-peptide concentrations were lower in patients than in control subjects during all infusion periods. GIP bolus administration evoked a significant increase in plasma insulin levels in both patients with type 2 diabetes and healthy subjects. In contrast, the continuous GIP infusion led to a weak increase in insulin secretion in both healthy subjects and type 2 diabetic patients. The dose-response relationship for the increase in insulin secretion after GIP bolus administration was similar in both groups, although at different degrees of beta-cell function. The stimulation of insulin secretion by GIP is stronger after its bolus administration than during continuous infusion. Even though the insulin secretory capacity is generally impaired in patients with type 2 diabetes, the relative sensitivity of insulin secretion to a bolus administration of GIP is almost preserved. Therefore, the existence of a specific GIP receptor defect in type 2 diabetes appears unlikely.

AB - A reduced insulinotropic effect of gastric inhibitory polypeptide (GIP) is a characteristic of patients with type 2 diabetes. It was the aim of this study to determine the response of insulin secretion to different GIP doses administered by intravenous bolus injection and via continuous infusion in both healthy subjects and patients with type 2 diabetes. Eight patients with type 2 diabetes and eight healthy subjects participated in a 240-min hyperglycemic clamp (140 mg/dl) with intravenous infusion of placebo, GIP at a low dose, and GIP at a high dose, each administered continuously over 60 min. Boluses of placebo, 20 pmol GIP/kg, and 80 pmol GIP/kg were injected intravenously at 0, 60, and 120 min, respectively. Capillary and venous blood was drawn for glucose, insulin, C-peptide, and GIP. Plasma insulin and C-peptide concentrations were lower in patients than in control subjects during all infusion periods. GIP bolus administration evoked a significant increase in plasma insulin levels in both patients with type 2 diabetes and healthy subjects. In contrast, the continuous GIP infusion led to a weak increase in insulin secretion in both healthy subjects and type 2 diabetic patients. The dose-response relationship for the increase in insulin secretion after GIP bolus administration was similar in both groups, although at different degrees of beta-cell function. The stimulation of insulin secretion by GIP is stronger after its bolus administration than during continuous infusion. Even though the insulin secretory capacity is generally impaired in patients with type 2 diabetes, the relative sensitivity of insulin secretion to a bolus administration of GIP is almost preserved. Therefore, the existence of a specific GIP receptor defect in type 2 diabetes appears unlikely.

M3 - Journal article

C2 - 15561915

VL - 53 Suppl 3

SP - S220-4

JO - Diabetes

JF - Diabetes

SN - 0012-1797

ER -

ID: 8417310