Stereomicroscopic and histologic changes in the colon of guinea pigs fed degraded carrageenan

Research output: Contribution to journal › Journal article › Research › peer-review

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Stereomicroscopic and histologic changes in the colon of guinea pigs fed degraded carrageenan. / Poulsen, Steen Seier.

In: Acta pathologica et microbiologica Scandinavica. Section A, Pathology, Vol. 88, No. 3, 05.1980, p. 135-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Poulsen, SS 1980, 'Stereomicroscopic and histologic changes in the colon of guinea pigs fed degraded carrageenan', Acta pathologica et microbiologica Scandinavica. Section A, Pathology, vol. 88, no. 3, pp. 135-41.

APA

Poulsen, S. S. (1980). Stereomicroscopic and histologic changes in the colon of guinea pigs fed degraded carrageenan. Acta pathologica et microbiologica Scandinavica. Section A, Pathology, 88(3), 135-41.

Vancouver

Poulsen SS. Stereomicroscopic and histologic changes in the colon of guinea pigs fed degraded carrageenan. Acta pathologica et microbiologica Scandinavica. Section A, Pathology. 1980 May;88(3):135-41.

Author

Poulsen, Steen Seier. / Stereomicroscopic and histologic changes in the colon of guinea pigs fed degraded carrageenan. In: Acta pathologica et microbiologica Scandinavica. Section A, Pathology. 1980 ; Vol. 88, No. 3. pp. 135-41.

Bibtex

@article{a9f9e680c7624db2a2e09cbfb1416c4b,
title = "Stereomicroscopic and histologic changes in the colon of guinea pigs fed degraded carrageenan",
abstract = "A colitis-like state induced in Guinea Pigs fed degraded carrageenan orally. By means of a combined semimacroscopic and histologic technique the course of the disease was followed during 28 days. The changes were primarily seen and became most prominent in the caecum. The first lesions were observed following 24 hours of treatment as small rounded foci initially with degenerative changes and inflammation in the surface epithelium, later forming superficial focal ulcerations. Ulcerative changes gradually progressed during the experiment, forming linear and later large, geographical ulcerations. Topographically the ulcerative process was strongly related to the larger submucosal vessels. Nonulcerated parts of the mucosa were not changed until following 7-14 days of treatment. The mucosa became bulging, granulated and finally villus-like. Accumulation of macrophages was found under the surface epithelium after 7-17 days. Possible pathogenetic mechanisms are discussed, especially the development of the early lesions and the significance of the macrophages.",
keywords = "Animals, Carrageenan, Colitis, Ulcerative, Colon, Food Additives, Guinea Pigs, Intestinal Mucosa, Time Factors",
author = "Poulsen, {Steen Seier}",
year = "1980",
month = may,
language = "English",
volume = "88",
pages = "135--41",
journal = "Acta Pathologica et Microbiologica Scandinavica - Section A Pathology",
issn = "0365-4184",
publisher = "Munksgaard International Publishers",
number = "3",

}

RIS

TY - JOUR

T1 - Stereomicroscopic and histologic changes in the colon of guinea pigs fed degraded carrageenan

AU - Poulsen, Steen Seier

PY - 1980/5

Y1 - 1980/5

N2 - A colitis-like state induced in Guinea Pigs fed degraded carrageenan orally. By means of a combined semimacroscopic and histologic technique the course of the disease was followed during 28 days. The changes were primarily seen and became most prominent in the caecum. The first lesions were observed following 24 hours of treatment as small rounded foci initially with degenerative changes and inflammation in the surface epithelium, later forming superficial focal ulcerations. Ulcerative changes gradually progressed during the experiment, forming linear and later large, geographical ulcerations. Topographically the ulcerative process was strongly related to the larger submucosal vessels. Nonulcerated parts of the mucosa were not changed until following 7-14 days of treatment. The mucosa became bulging, granulated and finally villus-like. Accumulation of macrophages was found under the surface epithelium after 7-17 days. Possible pathogenetic mechanisms are discussed, especially the development of the early lesions and the significance of the macrophages.

AB - A colitis-like state induced in Guinea Pigs fed degraded carrageenan orally. By means of a combined semimacroscopic and histologic technique the course of the disease was followed during 28 days. The changes were primarily seen and became most prominent in the caecum. The first lesions were observed following 24 hours of treatment as small rounded foci initially with degenerative changes and inflammation in the surface epithelium, later forming superficial focal ulcerations. Ulcerative changes gradually progressed during the experiment, forming linear and later large, geographical ulcerations. Topographically the ulcerative process was strongly related to the larger submucosal vessels. Nonulcerated parts of the mucosa were not changed until following 7-14 days of treatment. The mucosa became bulging, granulated and finally villus-like. Accumulation of macrophages was found under the surface epithelium after 7-17 days. Possible pathogenetic mechanisms are discussed, especially the development of the early lesions and the significance of the macrophages.

KW - Animals

KW - Carrageenan

KW - Colitis, Ulcerative

KW - Colon

KW - Food Additives

KW - Guinea Pigs

KW - Intestinal Mucosa

KW - Time Factors

M3 - Journal article

C2 - 7386207

VL - 88

SP - 135

EP - 141

JO - Acta Pathologica et Microbiologica Scandinavica - Section A Pathology

JF - Acta Pathologica et Microbiologica Scandinavica - Section A Pathology

SN - 0365-4184

IS - 3

ER -

ID: 47490060