Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities
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Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities. / Andersen, Ase B; Law, Ian; Ostrowski, Sisse R; Lebech, Anne Mette; Høyer-Hansen, Gunilla; Højgaard, Liselotte; Gerstoft, Jan; Ullum, Henrik; Kjaer, Andreas.
In: Neuroimmunomodulation, Vol. 13, No. 2, 2006, p. 69-75.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Self-reported fatigue common among optimally treated HIV patients: no correlation with cerebral FDG-PET scanning abnormalities
AU - Andersen, Ase B
AU - Law, Ian
AU - Ostrowski, Sisse R
AU - Lebech, Anne Mette
AU - Høyer-Hansen, Gunilla
AU - Højgaard, Liselotte
AU - Gerstoft, Jan
AU - Ullum, Henrik
AU - Kjaer, Andreas
N1 - Keywords: AIDS Dementia Complex; Adult; Aged; Anti-Retroviral Agents; CD4 Lymphocyte Count; Cerebral Cortex; Cohort Studies; Comorbidity; Fatigue Syndrome, Chronic; Female; Fluorodeoxyglucose F18; Glucose; HIV Infections; Humans; Inflammation Mediators; Interleukin-6; Male; Middle Aged; Positron-Emission Tomography; Questionnaires; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Tumor Necrosis Factor-alpha
PY - 2006
Y1 - 2006
N2 - OBJECTIVE: It was the aim of this study to determine the prevalence and severity of fatigue among optimally treated HIV patients and to investigate the potential association with systemic inflammation and abnormalities of the distribution of cerebral glucose metabolism. METHODS: A cohort of HIV patients (n = 95), known to be HIV positive for 5 years, on anti-retroviral therapy for a minimum of 3 years and with CD4 counts above 0.2 x 10(9) cells/l, completed a validated fatigue inventory, and plasma was analysed for pro-inflammatory markers including tumour necrosis factor-alpha, interleukin 6 and soluble urokinase receptor (suPAR) levels. The distribution of the regional cerebral metabolic rate of glucose was measured in a sub-group of patients suffering from severe fatigue (n = 9) and a group with no fatigue (n = 7) using fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) scanning. RESULTS: Fifteen percent suffered from severe fatigue, but no association with pro-inflammatory markers was found. About 50% of the FDG-PET-scanned patients showed minor abnormalities in the relative cerebral metabolic rate of glucose. These abnormalities were not associated with fatigue but tended to correlate with a short HIV history (p = 0.058), a low CD4 nadir (p = 0.082) and elevated tumour necrosis factor-alpha levels (p = 0.074). CONCLUSION: Fatigue is common among optimally treated HIV patients. FDG-PET-described signs of imminent neurodegeneration among HIV patients who had a low CD4 nadir may illustrate an aspect of HIV neuropathogenicity.
AB - OBJECTIVE: It was the aim of this study to determine the prevalence and severity of fatigue among optimally treated HIV patients and to investigate the potential association with systemic inflammation and abnormalities of the distribution of cerebral glucose metabolism. METHODS: A cohort of HIV patients (n = 95), known to be HIV positive for 5 years, on anti-retroviral therapy for a minimum of 3 years and with CD4 counts above 0.2 x 10(9) cells/l, completed a validated fatigue inventory, and plasma was analysed for pro-inflammatory markers including tumour necrosis factor-alpha, interleukin 6 and soluble urokinase receptor (suPAR) levels. The distribution of the regional cerebral metabolic rate of glucose was measured in a sub-group of patients suffering from severe fatigue (n = 9) and a group with no fatigue (n = 7) using fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) scanning. RESULTS: Fifteen percent suffered from severe fatigue, but no association with pro-inflammatory markers was found. About 50% of the FDG-PET-scanned patients showed minor abnormalities in the relative cerebral metabolic rate of glucose. These abnormalities were not associated with fatigue but tended to correlate with a short HIV history (p = 0.058), a low CD4 nadir (p = 0.082) and elevated tumour necrosis factor-alpha levels (p = 0.074). CONCLUSION: Fatigue is common among optimally treated HIV patients. FDG-PET-described signs of imminent neurodegeneration among HIV patients who had a low CD4 nadir may illustrate an aspect of HIV neuropathogenicity.
U2 - 10.1159/000095222
DO - 10.1159/000095222
M3 - Journal article
C2 - 16926555
VL - 13
SP - 69
EP - 75
JO - NeuroImmunoModulation
JF - NeuroImmunoModulation
SN - 1021-7401
IS - 2
ER -
ID: 12796781