Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy. / Diness, Jonas G.; Bentzen, Bo H.; S. Sørensen, Ulrik; Grunnet, Morten.

In: Journal of Cardiovascular Pharmacology, Vol. 66, No. 5, 11.2015, p. 441-448.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Diness, JG, Bentzen, BH, S. Sørensen, U & Grunnet, M 2015, 'Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy', Journal of Cardiovascular Pharmacology, vol. 66, no. 5, pp. 441-448. https://doi.org/10.1097/FJC.0000000000000249

APA

Diness, J. G., Bentzen, B. H., S. Sørensen, U., & Grunnet, M. (2015). Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy. Journal of Cardiovascular Pharmacology, 66(5), 441-448. https://doi.org/10.1097/FJC.0000000000000249

Vancouver

Diness JG, Bentzen BH, S. Sørensen U, Grunnet M. Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy. Journal of Cardiovascular Pharmacology. 2015 Nov;66(5):441-448. https://doi.org/10.1097/FJC.0000000000000249

Author

Diness, Jonas G. ; Bentzen, Bo H. ; S. Sørensen, Ulrik ; Grunnet, Morten. / Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy. In: Journal of Cardiovascular Pharmacology. 2015 ; Vol. 66, No. 5. pp. 441-448.

Bibtex

@article{b99a3699390540ab8744134d46ab52c8,
title = "Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy",
abstract = "Small-conductance Ca2+-activated potassium (SK) channels are relative newcomers within the field of cardiac electrophysiology. In recent years, an increased focus has been given to these channels since they might constitute a relatively atrial selective target. The present review will give a general introduction to SK channels followed by their proposed function in the heart under normal and pathophysiological conditions. It is revealed how anti-arrhythmic effects can be obtained by SK channel inhibition in a number of species in situations of atrial fibrillation. On the contrary, the beneficial effects of SK channel inhibition in situations of heart failure are questionable and still needs investigation. The understanding of cardiac SK channels is rapidly increasing these years, and hopefully this will clarify whether SK channel inhibition has potential as a new anti-atrial fibrillation principle.",
author = "Diness, {Jonas G.} and Bentzen, {Bo H.} and {S. S{\o}rensen}, Ulrik and Morten Grunnet",
year = "2015",
month = nov,
doi = "10.1097/FJC.0000000000000249",
language = "English",
volume = "66",
pages = "441--448",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Role of calcium activated potassium channels in atrial fibrillation pathophysiology and therapy

AU - Diness, Jonas G.

AU - Bentzen, Bo H.

AU - S. Sørensen, Ulrik

AU - Grunnet, Morten

PY - 2015/11

Y1 - 2015/11

N2 - Small-conductance Ca2+-activated potassium (SK) channels are relative newcomers within the field of cardiac electrophysiology. In recent years, an increased focus has been given to these channels since they might constitute a relatively atrial selective target. The present review will give a general introduction to SK channels followed by their proposed function in the heart under normal and pathophysiological conditions. It is revealed how anti-arrhythmic effects can be obtained by SK channel inhibition in a number of species in situations of atrial fibrillation. On the contrary, the beneficial effects of SK channel inhibition in situations of heart failure are questionable and still needs investigation. The understanding of cardiac SK channels is rapidly increasing these years, and hopefully this will clarify whether SK channel inhibition has potential as a new anti-atrial fibrillation principle.

AB - Small-conductance Ca2+-activated potassium (SK) channels are relative newcomers within the field of cardiac electrophysiology. In recent years, an increased focus has been given to these channels since they might constitute a relatively atrial selective target. The present review will give a general introduction to SK channels followed by their proposed function in the heart under normal and pathophysiological conditions. It is revealed how anti-arrhythmic effects can be obtained by SK channel inhibition in a number of species in situations of atrial fibrillation. On the contrary, the beneficial effects of SK channel inhibition in situations of heart failure are questionable and still needs investigation. The understanding of cardiac SK channels is rapidly increasing these years, and hopefully this will clarify whether SK channel inhibition has potential as a new anti-atrial fibrillation principle.

U2 - 10.1097/FJC.0000000000000249

DO - 10.1097/FJC.0000000000000249

M3 - Journal article

C2 - 25830485

VL - 66

SP - 441

EP - 448

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - 5

ER -

ID: 135363194