Resolution of the three dimensional structure of components of the glomerular filtration barrier
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Resolution of the three dimensional structure of components of the glomerular filtration barrier. / Arkill, Kenton P; Qvortrup, Klaus; Starborg, Tobias; Mantell, Judith M; Knupp, Carlo; Michel, Charles C; Harper, Steve J; Salmon, Andy Hj; Squire, John M; Bates, Dave O; Neal, Chris R.
In: B M C Nephrology, Vol. 15, No. 1, 24, 01.02.2014, p. 1-13.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Resolution of the three dimensional structure of components of the glomerular filtration barrier
AU - Arkill, Kenton P
AU - Qvortrup, Klaus
AU - Starborg, Tobias
AU - Mantell, Judith M
AU - Knupp, Carlo
AU - Michel, Charles C
AU - Harper, Steve J
AU - Salmon, Andy Hj
AU - Squire, John M
AU - Bates, Dave O
AU - Neal, Chris R
PY - 2014/2/1
Y1 - 2014/2/1
N2 - The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on the vascular side, and the sub-podocyte space on the urinary side. To investigate the structure of these additional layers is difficult as it requires three-dimensional reconstruction of delicate sub-microscopic (
AB - The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane and the podocyte foot processes. However, recent studies have suggested that at least two additional layers contribute to the function of the GFB, the endothelial glycocalyx on the vascular side, and the sub-podocyte space on the urinary side. To investigate the structure of these additional layers is difficult as it requires three-dimensional reconstruction of delicate sub-microscopic (
U2 - 10.1186/1471-2369-15-24
DO - 10.1186/1471-2369-15-24
M3 - Journal article
C2 - 24484633
VL - 15
SP - 1
EP - 13
JO - BMC Nephrology
JF - BMC Nephrology
SN - 1471-2369
IS - 1
M1 - 24
ER -
ID: 98563433