Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1

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Regulation and control of nitric oxide (NO) in macrophages : Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1. / Kovacevic, Zaklina; Sahni, Sumit; Lok, K.H.; Davies, M J; Wink, D A; Richardson, Des R.

In: B B A - Reviews on Cancer, Vol. 1861, No. 5 Pt A, 05.2017, p. 995-999.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Kovacevic, Z, Sahni, S, Lok, KH, Davies, MJ, Wink, DA & Richardson, DR 2017, 'Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1', B B A - Reviews on Cancer, vol. 1861, no. 5 Pt A, pp. 995-999. https://doi.org/10.1016/j.bbagen.2017.02.021

APA

Kovacevic, Z., Sahni, S., Lok, K. H., Davies, M. J., Wink, D. A., & Richardson, D. R. (2017). Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1. B B A - Reviews on Cancer, 1861(5 Pt A), 995-999. https://doi.org/10.1016/j.bbagen.2017.02.021

Vancouver

Kovacevic Z, Sahni S, Lok KH, Davies MJ, Wink DA, Richardson DR. Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1. B B A - Reviews on Cancer. 2017 May;1861(5 Pt A):995-999. https://doi.org/10.1016/j.bbagen.2017.02.021

Author

Kovacevic, Zaklina ; Sahni, Sumit ; Lok, K.H. ; Davies, M J ; Wink, D A ; Richardson, Des R. / Regulation and control of nitric oxide (NO) in macrophages : Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1. In: B B A - Reviews on Cancer. 2017 ; Vol. 1861, No. 5 Pt A. pp. 995-999.

Bibtex

@article{2adacbc724be46a89434a1d9a7b82083,
title = "Regulation and control of nitric oxide (NO) in macrophages: Protecting the {"}professional killer cell{"} from its own cytotoxic arsenal via MRP1 and GSTP1",
abstract = "We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-M{\O}) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be freely diffusible, is a tightly-regulated species in M1-M{\O}s. These control systems prevent NO cytotoxicity and may be responsible for delivering cytotoxic NO as DNICs via MRP1 from M1-M{\O}s, to tumor cell targets.",
keywords = "Journal Article, Review",
author = "Zaklina Kovacevic and Sumit Sahni and K.H. Lok and Davies, {M J} and Wink, {D A} and Richardson, {Des R}",
note = "Copyright {\circledC} 2017 Elsevier B.V. All rights reserved.",
year = "2017",
month = "5",
doi = "10.1016/j.bbagen.2017.02.021",
language = "English",
volume = "1861",
pages = "995--999",
journal = "B B A - Reviews on Cancer",
issn = "0304-419X",
publisher = "Elsevier",
number = "5 Pt A",

}

RIS

TY - JOUR

T1 - Regulation and control of nitric oxide (NO) in macrophages

T2 - Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1

AU - Kovacevic, Zaklina

AU - Sahni, Sumit

AU - Lok, K.H.

AU - Davies, M J

AU - Wink, D A

AU - Richardson, Des R

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017/5

Y1 - 2017/5

N2 - We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MØ) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be freely diffusible, is a tightly-regulated species in M1-MØs. These control systems prevent NO cytotoxicity and may be responsible for delivering cytotoxic NO as DNICs via MRP1 from M1-MØs, to tumor cell targets.

AB - We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MØ) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be freely diffusible, is a tightly-regulated species in M1-MØs. These control systems prevent NO cytotoxicity and may be responsible for delivering cytotoxic NO as DNICs via MRP1 from M1-MØs, to tumor cell targets.

KW - Journal Article

KW - Review

U2 - 10.1016/j.bbagen.2017.02.021

DO - 10.1016/j.bbagen.2017.02.021

M3 - Review

C2 - 28219722

VL - 1861

SP - 995

EP - 999

JO - B B A - Reviews on Cancer

JF - B B A - Reviews on Cancer

SN - 0304-419X

IS - 5 Pt A

ER -

ID: 182331125