Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

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  • João M. Anghinoni
  • Paloma T. Birmann
  • Marcia J. da Rocha
  • Caroline S. Gomes
  • Davies, Michael J.
  • César A. Brüning
  • Lucielli Savegnago
  • Eder J. Lenardão

Selenium is an essential trace element in living organisms, and is present in selenoenzymes with antioxidant activity, like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR). The search for small selenium-containing molecules that mimic selenoenzymes is a strong field of research in organic and medicinal chemistry. In this review, we review the synthesis and bioassays of new and known organoselenium compounds with antioxidant activity, covering the last five years. A detailed description of the synthetic procedures and the performed in vitro and in vivo bioassays is presented, highlighting the most active compounds in each series.

Original languageEnglish
Article number7349
Issue number21
Pages (from-to)1-45
Publication statusPublished - 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

    Research areas

  • ABTS, antioxidant, catalase, DPPH, FRAP, GPx-like, lipid peroxidation, organoselenium, SOD

ID: 374307933