Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction. / Hundahl, Laura A.; Tfelt-Hansen, Jacob; Jespersen, Thomas.
In: Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 22, No. 6, 11.2017, p. 514-528.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Rat Models of Ventricular Fibrillation Following Acute Myocardial Infarction
AU - Hundahl, Laura A.
AU - Tfelt-Hansen, Jacob
AU - Jespersen, Thomas
PY - 2017/11
Y1 - 2017/11
N2 - A number of animal models have been designed in order to unravel the underlying mechanisms of acute ischemia-induced arrhythmias and to test compounds and interventions for antiarrhythmic therapy. This is important as acute myocardial infarction (AMI) continues to be the major cause of sudden cardiac death, and we are yet to discover safe and effective treatments of the lethal arrhythmias occurring in the acute setting. Animal models therefore continue to be relevant for our understanding and treatment of acute ischemic arrhythmias. This review discusses the applicability of the rat as a model for ventricular arrhythmias occurring during the acute phase of AMI. It provides a description of models developed, advantages and disadvantages of rats, as well as an overview of the most important interventions investigated and the relevance for human pathophysiology.
AB - A number of animal models have been designed in order to unravel the underlying mechanisms of acute ischemia-induced arrhythmias and to test compounds and interventions for antiarrhythmic therapy. This is important as acute myocardial infarction (AMI) continues to be the major cause of sudden cardiac death, and we are yet to discover safe and effective treatments of the lethal arrhythmias occurring in the acute setting. Animal models therefore continue to be relevant for our understanding and treatment of acute ischemic arrhythmias. This review discusses the applicability of the rat as a model for ventricular arrhythmias occurring during the acute phase of AMI. It provides a description of models developed, advantages and disadvantages of rats, as well as an overview of the most important interventions investigated and the relevance for human pathophysiology.
KW - myocardial infarction
KW - rat models
KW - sudden cardiac death
KW - ventricular arrhythmias
U2 - 10.1177/1074248417702894
DO - 10.1177/1074248417702894
M3 - Journal article
C2 - 28381093
AN - SCOPUS:85032289645
VL - 22
SP - 514
EP - 528
JO - Journal of Cardiovascular Pharmacology and Therapeutics
JF - Journal of Cardiovascular Pharmacology and Therapeutics
SN - 1074-2484
IS - 6
ER -
ID: 187624771