Prostaglandin H synthase immunoreactivity in human gut. An immunohistochemical study

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Standard

Prostaglandin H synthase immunoreactivity in human gut. An immunohistochemical study. / Mikkelsen, H B; Rumessen, J J; Qvortrup, K.

In: Histochemistry, Vol. 96, No. 4, 1991, p. 295-299.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mikkelsen, HB, Rumessen, JJ & Qvortrup, K 1991, 'Prostaglandin H synthase immunoreactivity in human gut. An immunohistochemical study', Histochemistry, vol. 96, no. 4, pp. 295-299.

APA

Mikkelsen, H. B., Rumessen, J. J., & Qvortrup, K. (1991). Prostaglandin H synthase immunoreactivity in human gut. An immunohistochemical study. Histochemistry, 96(4), 295-299.

Vancouver

Mikkelsen HB, Rumessen JJ, Qvortrup K. Prostaglandin H synthase immunoreactivity in human gut. An immunohistochemical study. Histochemistry. 1991;96(4):295-299.

Author

Mikkelsen, H B ; Rumessen, J J ; Qvortrup, K. / Prostaglandin H synthase immunoreactivity in human gut. An immunohistochemical study. In: Histochemistry. 1991 ; Vol. 96, No. 4. pp. 295-299.

Bibtex

@article{6758041d46b443bba9b0f5ad92a2f88d,
title = "Prostaglandin H synthase immunoreactivity in human gut. An immunohistochemical study",
abstract = "Prostaglandins exhibit a variety of actions on intestinal smooth muscle depending upon the type, dose and muscle layer studied. As the cellular origin of prostaglandin H (PGH) synthase has not been established with certainty in the human gut wall, we studied the localization of PGH synthase in the human duodenum, jejunum, ileum and colon by immunohistochemistry. PGH synthase immunoreactivity appeared to be similar in all segments of the intestine. Most smooth muscle cells seemed to contain PGH synthase; however, the reaction in the lamina muscularis mucosae was much stronger than in the longitudinal and circular muscle layers. Endothelial cells in capillaries and larger vessels showed a positive reaction. In addition, unidentified cells in subserosa, at the level of Auerbach's plexus and in the submucosa were stained. We concluded that the smooth muscle cells of the human gut has a rather large capacity for PGH synthesis and the present results may provide a basis for a better understanding of both normal physiological functions as well as intestinal disease states involving disorders of prostaglandin synthesis.",
keywords = "Aged, Aged, 80 and over, Antibodies, Colon, Duodenum, Endothelium, Vascular, Humans, Ileum, Immunohistochemistry, Intestinal Mucosa, Intestine, Large, Intestine, Small, Jejunum, Middle Aged, Muscle, Smooth, Prostaglandin-Endoperoxide Synthases, Staining and Labeling, Journal Article",
author = "Mikkelsen, {H B} and Rumessen, {J J} and K Qvortrup",
year = "1991",
language = "English",
volume = "96",
pages = "295--299",
journal = "Histochemistry",
issn = "0301-5564",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Prostaglandin H synthase immunoreactivity in human gut. An immunohistochemical study

AU - Mikkelsen, H B

AU - Rumessen, J J

AU - Qvortrup, K

PY - 1991

Y1 - 1991

N2 - Prostaglandins exhibit a variety of actions on intestinal smooth muscle depending upon the type, dose and muscle layer studied. As the cellular origin of prostaglandin H (PGH) synthase has not been established with certainty in the human gut wall, we studied the localization of PGH synthase in the human duodenum, jejunum, ileum and colon by immunohistochemistry. PGH synthase immunoreactivity appeared to be similar in all segments of the intestine. Most smooth muscle cells seemed to contain PGH synthase; however, the reaction in the lamina muscularis mucosae was much stronger than in the longitudinal and circular muscle layers. Endothelial cells in capillaries and larger vessels showed a positive reaction. In addition, unidentified cells in subserosa, at the level of Auerbach's plexus and in the submucosa were stained. We concluded that the smooth muscle cells of the human gut has a rather large capacity for PGH synthesis and the present results may provide a basis for a better understanding of both normal physiological functions as well as intestinal disease states involving disorders of prostaglandin synthesis.

AB - Prostaglandins exhibit a variety of actions on intestinal smooth muscle depending upon the type, dose and muscle layer studied. As the cellular origin of prostaglandin H (PGH) synthase has not been established with certainty in the human gut wall, we studied the localization of PGH synthase in the human duodenum, jejunum, ileum and colon by immunohistochemistry. PGH synthase immunoreactivity appeared to be similar in all segments of the intestine. Most smooth muscle cells seemed to contain PGH synthase; however, the reaction in the lamina muscularis mucosae was much stronger than in the longitudinal and circular muscle layers. Endothelial cells in capillaries and larger vessels showed a positive reaction. In addition, unidentified cells in subserosa, at the level of Auerbach's plexus and in the submucosa were stained. We concluded that the smooth muscle cells of the human gut has a rather large capacity for PGH synthesis and the present results may provide a basis for a better understanding of both normal physiological functions as well as intestinal disease states involving disorders of prostaglandin synthesis.

KW - Aged

KW - Aged, 80 and over

KW - Antibodies

KW - Colon

KW - Duodenum

KW - Endothelium, Vascular

KW - Humans

KW - Ileum

KW - Immunohistochemistry

KW - Intestinal Mucosa

KW - Intestine, Large

KW - Intestine, Small

KW - Jejunum

KW - Middle Aged

KW - Muscle, Smooth

KW - Prostaglandin-Endoperoxide Synthases

KW - Staining and Labeling

KW - Journal Article

M3 - Journal article

C2 - 1723975

VL - 96

SP - 295

EP - 299

JO - Histochemistry

JF - Histochemistry

SN - 0301-5564

IS - 4

ER -

ID: 176538763