TY - JOUR

T1 - Predictive value of left atrial strain in relation to atrial fibrillation following acute myocardial infarction

AU - Svartstein, Anne Sophie Winther

AU - Lassen, Mats Højbjerg

AU - Skaarup, Kristoffer Grundtvig

AU - Grove, Gabriela Lladó

AU - Vyff, Frederikke

AU - Ravnkilde, Kirstine

AU - Pedersen, Sune

AU - Galatius, Søren

AU - Modin, Daniel

AU - Biering-Sørensen, Tor

N1 - Publisher Copyright: © 2022 The Author(s)

PY - 2022

Y1 - 2022

N2 - Background: Atrial fibrillation (AF) is the most common arrythmia following ST-segment elevation myocardial infarction (STEMI) and can lead to stroke and other heart-related diseases. This study aimed to determine the prognostic value of left atrial (LA) strain, obtained by speckle tracking echocardiography (STE), in predicting incident AF outcomes following STEMI treated with primary percutaneous coronary intervention (pPCI). Methods and results: This prospective study comprised of 392 STEMI patients treated with pPCI. The patients had an echocardiography performed at a median of two days after their STEMI. Along with conventional measures, LA strain was obtained by speckle tracking from two apical projections. The outcome was new-onset atrial fibrillation. LA reservoir, contractile and conduit strain were measurable from echocardiograms of 303 included patients. At a median follow-up time of 5.6 years (IQR: 5.0–6.1 years), 18 patients (6,3%) developed incident AF. Mean age was 62.0 years ±11.5 and follow-up was 100%. Significantly lower LA strain values were observed in patients who experienced AF during follow-up as compared to patients who didn't. Both reservoir, contractile and conduit strain were significant univariable predictors. In the multivariable model, only LA reservoir strain remained a significant independent predictor of AF. Conclusion: Left atrial reservoir strain obtained by two-dimensional speckle tracking echocardiography is an independent predictor of incident AF following STEMI.

AB - Background: Atrial fibrillation (AF) is the most common arrythmia following ST-segment elevation myocardial infarction (STEMI) and can lead to stroke and other heart-related diseases. This study aimed to determine the prognostic value of left atrial (LA) strain, obtained by speckle tracking echocardiography (STE), in predicting incident AF outcomes following STEMI treated with primary percutaneous coronary intervention (pPCI). Methods and results: This prospective study comprised of 392 STEMI patients treated with pPCI. The patients had an echocardiography performed at a median of two days after their STEMI. Along with conventional measures, LA strain was obtained by speckle tracking from two apical projections. The outcome was new-onset atrial fibrillation. LA reservoir, contractile and conduit strain were measurable from echocardiograms of 303 included patients. At a median follow-up time of 5.6 years (IQR: 5.0–6.1 years), 18 patients (6,3%) developed incident AF. Mean age was 62.0 years ±11.5 and follow-up was 100%. Significantly lower LA strain values were observed in patients who experienced AF during follow-up as compared to patients who didn't. Both reservoir, contractile and conduit strain were significant univariable predictors. In the multivariable model, only LA reservoir strain remained a significant independent predictor of AF. Conclusion: Left atrial reservoir strain obtained by two-dimensional speckle tracking echocardiography is an independent predictor of incident AF following STEMI.

KW - Atrial fibrillation

KW - Left atrial strain

KW - Speckle tracking echocardiography

UR - http://www.scopus.com/inward/record.url?scp=85132429742&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2022.05.026

DO - 10.1016/j.ijcard.2022.05.026

M3 - Journal article

C2 - 35577164

AN - SCOPUS:85132429742

VL - 364

SP - 52

EP - 59

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -