Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): The NORDIC NEC study

Research output: Contribution to journalJournal articleResearchpeer-review

  • H Sorbye
  • S Welin
  • Langer, Seppo W.
  • L W Vestermark
  • N Holt
  • P Osterlund
  • S Dueland
  • E Hofsli
  • M G Guren
  • K Ohrling
  • E Birkemeyer
  • E Thiis-Evensen
  • Matteo Biagini
  • H Gronbaek
  • L M Soveri
  • I H Olsen
  • B Federspiel
  • J Assmus
  • E T Janson
  • Knigge, Ulrich
Background As studies on gastrointestinal neuroendocrine carcinoma (WHO G3) (GI-NEC) are limited, we reviewed clinical data to identify predictive and prognostic markers for advanced GI-NEC patients. Patients and methods Data from advanced GI-NEC patients diagnosed 2000-2009 were retrospectively registered at 12 Nordic hospitals. Results The median survival was 11 months in 252 patients given palliative chemotherapy and 1 month in 53 patients receiving best supportive care (BSC) only. The response rate to first-line chemotherapy was 31% and 33% had stable disease. Ki-67 
Original languageEnglish
JournalAnnals of Oncology
Volume24
Issue number1
Pages (from-to)152-60
Number of pages9
ISSN0923-7534
DOIs
Publication statusPublished - 2013

ID: 48501024