Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature
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Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature. / Kaagaard, Molly D.; Wegener, Alma; Gomes, Laura C.; Holm, Anna E.; Lima, Karine O.; Matos, Luan O.; Vieira, Isabelle V. M.; de Souza, Rodrigo Medeiros; Vestergaard, Lasse S.; Farias Marinho, Claudio Romero; Dos Santos, Flavia Barreto; Biering-Sorensen, Tor; Silvestre, Odilson M.; Brainin, Philip.
In: PLoS ONE, Vol. 17, No. 11, 0276725, 18.11.2022.Research output: Contribution to journal › Review › Research › peer-review
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T1 - Potential role of transthoracic echocardiography for screening LV systolic dysfunction in patients with a history of dengue infection. A cross-sectional and cohort study and review of the literature
AU - Kaagaard, Molly D.
AU - Wegener, Alma
AU - Gomes, Laura C.
AU - Holm, Anna E.
AU - Lima, Karine O.
AU - Matos, Luan O.
AU - Vieira, Isabelle V. M.
AU - de Souza, Rodrigo Medeiros
AU - Vestergaard, Lasse S.
AU - Farias Marinho, Claudio Romero
AU - Dos Santos, Flavia Barreto
AU - Biering-Sorensen, Tor
AU - Silvestre, Odilson M.
AU - Brainin, Philip
PY - 2022/11/18
Y1 - 2022/11/18
N2 - Background Dengue virus can affect the cardiovascular system and men may be at higher risk of severe complications than women. We hypothesized that clinical dengue virus (DENV) infection could induce myocardial alterations of the left ventricle (LV) and that these changes could be detected by transthoracic echocardiography.Methodology/Principal findings We examined individuals from Acre in the Amazon Basin of Brazil in 2020 as part of the Malaria Heart Study. By questionnaires we collected information on self-reported prior dengue infection. All individuals underwent transthoracic echocardiography, analysis of left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS). We included 521 persons (mean age 4015 years, 39% men, 50% urban areas) of which 253 (49%) had a history of dengue infection. In multivariable models adjusted for clinical and sociodemographic data, a history of self-reported dengue was significantly associated with lower LVEF (beta = -2.37, P < 0.01) and lower GLS (beta = 1.08, P < 0.01) in men, whereas no significant associations were found in women (P > 0.05). In line with these findings, men with a history of dengue had higher rates of LV systolic dysfunction (LVEF < 50% = 20%; GLS < 16% = 17%) than those without a history of dengue (LVEF < 50% = 7%; GLS < 16% = 8%; P < 0.01 and 0.06, respectively).Conclusions/Significance The findings of this study suggest that a clinical infection by dengue virus could induce myocardial alterations, mainly in men and in the LV, which could be detected by conventional transthoracic echocardiography. Hence, these results highlight a potential role of echocardiography for screening LV dysfunction in participants with a history of dengue infection. Further larger studies are warranted to validate the findings of this study.
AB - Background Dengue virus can affect the cardiovascular system and men may be at higher risk of severe complications than women. We hypothesized that clinical dengue virus (DENV) infection could induce myocardial alterations of the left ventricle (LV) and that these changes could be detected by transthoracic echocardiography.Methodology/Principal findings We examined individuals from Acre in the Amazon Basin of Brazil in 2020 as part of the Malaria Heart Study. By questionnaires we collected information on self-reported prior dengue infection. All individuals underwent transthoracic echocardiography, analysis of left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS). We included 521 persons (mean age 4015 years, 39% men, 50% urban areas) of which 253 (49%) had a history of dengue infection. In multivariable models adjusted for clinical and sociodemographic data, a history of self-reported dengue was significantly associated with lower LVEF (beta = -2.37, P < 0.01) and lower GLS (beta = 1.08, P < 0.01) in men, whereas no significant associations were found in women (P > 0.05). In line with these findings, men with a history of dengue had higher rates of LV systolic dysfunction (LVEF < 50% = 20%; GLS < 16% = 17%) than those without a history of dengue (LVEF < 50% = 7%; GLS < 16% = 8%; P < 0.01 and 0.06, respectively).Conclusions/Significance The findings of this study suggest that a clinical infection by dengue virus could induce myocardial alterations, mainly in men and in the LV, which could be detected by conventional transthoracic echocardiography. Hence, these results highlight a potential role of echocardiography for screening LV dysfunction in participants with a history of dengue infection. Further larger studies are warranted to validate the findings of this study.
KW - CARDIAC INVOLVEMENT
KW - CHIKUNGUNYA FEVER
KW - VIRUS-INFECTION
KW - MYOCARDITIS
KW - HEART
KW - BURDEN
KW - ASSOCIATION
KW - CHILDREN
KW - DISEASE
U2 - 10.1371/journal.pone.0276725
DO - 10.1371/journal.pone.0276725
M3 - Review
C2 - 36399460
VL - 17
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 11
M1 - 0276725
ER -
ID: 338350999