TY - JOUR

T1 - Photothermal therapy as adjuvant to surgery in an orthotopic mouse model of human fibrosarcoma

AU - Simón, Marina

AU - Jørgensen, Jesper Tranekjær

AU - Melander, Fredrik

AU - Andresen, Thomas Lars

AU - Christensen, Anders

AU - Kjaer, Andreas

PY - 2021

Y1 - 2021

N2 - Surgery is still the first-line treatment for multiple solid cancers. However, recurrence is a common issue, especially when dealing with aggressive tumors or tumors that are difficult to completely remove due to their location. Getting clear surgical margins can be challenging, but treatment strategies combining surgery with other anti-cancer therapies can potentially improve the outcome. Photothermal therapy (PTT) is a technique that relies on photoabsorbing agents, such as gold nanoparticles, to transform light into local hyperthermia. This technique can be used to ablate tumor tissue where the photoabsorbing agent accumulates, sparing healthy surrounding tissue. In this study, we examined the potential of gold nanoparticle-based PTT as an adjuvant treatment to surgery in a mouse model of human fibrosarcoma. For this we performed subtotal tumor resection to mimic a clinical situation where total tumor removal is not achieved, and subsequent PTT was applied on the surgical field. Our results showed that animals undergoing adjuvant PTT after surgery presented sustained delayed tumor growth and improved survival when compared to animals that only underwent surgery. We believe that these findings show the potential of PTT as an adjuvant method to traditional tumor surgery and could pave way to more personalized treatment options.

AB - Surgery is still the first-line treatment for multiple solid cancers. However, recurrence is a common issue, especially when dealing with aggressive tumors or tumors that are difficult to completely remove due to their location. Getting clear surgical margins can be challenging, but treatment strategies combining surgery with other anti-cancer therapies can potentially improve the outcome. Photothermal therapy (PTT) is a technique that relies on photoabsorbing agents, such as gold nanoparticles, to transform light into local hyperthermia. This technique can be used to ablate tumor tissue where the photoabsorbing agent accumulates, sparing healthy surrounding tissue. In this study, we examined the potential of gold nanoparticle-based PTT as an adjuvant treatment to surgery in a mouse model of human fibrosarcoma. For this we performed subtotal tumor resection to mimic a clinical situation where total tumor removal is not achieved, and subsequent PTT was applied on the surgical field. Our results showed that animals undergoing adjuvant PTT after surgery presented sustained delayed tumor growth and improved survival when compared to animals that only underwent surgery. We believe that these findings show the potential of PTT as an adjuvant method to traditional tumor surgery and could pave way to more personalized treatment options.

KW - Fibrosarcoma

KW - Magnetic resonance imaging (MRI)

KW - Photothermal therapy (PTT)

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=85119378032&partnerID=8YFLogxK

U2 - 10.3390/cancers13225820

DO - 10.3390/cancers13225820

M3 - Journal article

C2 - 34830974

AN - SCOPUS:85119378032

VL - 13

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 22

M1 - 5820

ER -