PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe

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Standard

PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe. / Severin, G. W.; Fonslet, J.; Kristensen, L. K.; Nielsen, C. H.; Jensen, A. I.; Kjær, A.; Mazar, A. P.; Johnston, K.; Köster, U.

In: Scientific Reports, Vol. 12, No. 1, 3863, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Severin, GW, Fonslet, J, Kristensen, LK, Nielsen, CH, Jensen, AI, Kjær, A, Mazar, AP, Johnston, K & Köster, U 2022, 'PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe', Scientific Reports, vol. 12, no. 1, 3863. https://doi.org/10.1038/s41598-022-07147-x

APA

Severin, G. W., Fonslet, J., Kristensen, L. K., Nielsen, C. H., Jensen, A. I., Kjær, A., Mazar, A. P., Johnston, K., & Köster, U. (2022). PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe. Scientific Reports, 12(1), [3863]. https://doi.org/10.1038/s41598-022-07147-x

Vancouver

Severin GW, Fonslet J, Kristensen LK, Nielsen CH, Jensen AI, Kjær A et al. PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe. Scientific Reports. 2022;12(1). 3863. https://doi.org/10.1038/s41598-022-07147-x

Author

Severin, G. W. ; Fonslet, J. ; Kristensen, L. K. ; Nielsen, C. H. ; Jensen, A. I. ; Kjær, A. ; Mazar, A. P. ; Johnston, K. ; Köster, U. / PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe. In: Scientific Reports. 2022 ; Vol. 12, No. 1.

Bibtex

@article{95d41667e7754a2e859d49c4ae25299e,
title = "PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe",
abstract = "The in vivo-generator radionuclides 140Nd (t1/2 = 3.4 d) and 134Ce (t1/2 = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair, making it an appropriate targeting vector for investigating the fate of in vivo generator daughters on internalizing probes. Ante-mortem and post-mortem PET imaging at 120 h post-injection gave no indication of redistribution of the positron emitting daughter nuclides 134La and 140Pr from tumor tissue (p > 0.5). The lack of redistribution indicates that the parent radionuclides 134Ce and 140Nd could be considered as long-lived PET-diagnostic matches to therapeutic radionuclides like 177Lu, 161Tb and 225Ac when internalizing bioconjugates are employed.",
author = "Severin, {G. W.} and J. Fonslet and Kristensen, {L. K.} and Nielsen, {C. H.} and Jensen, {A. I.} and A. Kj{\ae}r and Mazar, {A. P.} and K. Johnston and U. K{\"o}ster",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
doi = "10.1038/s41598-022-07147-x",
language = "English",
volume = "12",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - PET in vivo generators 134Ce and 140Nd on an internalizing monoclonal antibody probe

AU - Severin, G. W.

AU - Fonslet, J.

AU - Kristensen, L. K.

AU - Nielsen, C. H.

AU - Jensen, A. I.

AU - Kjær, A.

AU - Mazar, A. P.

AU - Johnston, K.

AU - Köster, U.

N1 - Publisher Copyright: © 2022, The Author(s).

PY - 2022

Y1 - 2022

N2 - The in vivo-generator radionuclides 140Nd (t1/2 = 3.4 d) and 134Ce (t1/2 = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair, making it an appropriate targeting vector for investigating the fate of in vivo generator daughters on internalizing probes. Ante-mortem and post-mortem PET imaging at 120 h post-injection gave no indication of redistribution of the positron emitting daughter nuclides 134La and 140Pr from tumor tissue (p > 0.5). The lack of redistribution indicates that the parent radionuclides 134Ce and 140Nd could be considered as long-lived PET-diagnostic matches to therapeutic radionuclides like 177Lu, 161Tb and 225Ac when internalizing bioconjugates are employed.

AB - The in vivo-generator radionuclides 140Nd (t1/2 = 3.4 d) and 134Ce (t1/2 = 3.2 d) were used to trace a urokinase-type plasminogen activator (uPA)-targeting mouse monoclonal antibody, ATN-291, in U87 MG xenograft tumor-bearing mice. ATN-291 is known to internalize on the uPA/uPA-receptor pair, making it an appropriate targeting vector for investigating the fate of in vivo generator daughters on internalizing probes. Ante-mortem and post-mortem PET imaging at 120 h post-injection gave no indication of redistribution of the positron emitting daughter nuclides 134La and 140Pr from tumor tissue (p > 0.5). The lack of redistribution indicates that the parent radionuclides 134Ce and 140Nd could be considered as long-lived PET-diagnostic matches to therapeutic radionuclides like 177Lu, 161Tb and 225Ac when internalizing bioconjugates are employed.

UR - http://www.scopus.com/inward/record.url?scp=85126078846&partnerID=8YFLogxK

U2 - 10.1038/s41598-022-07147-x

DO - 10.1038/s41598-022-07147-x

M3 - Journal article

C2 - 35264588

AN - SCOPUS:85126078846

VL - 12

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 3863

ER -

ID: 339129858