Occurrence, distribution and motor effects of galanin in the porcine lower esophageal sphincter

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Occurrence, distribution and motor effects of galanin in the porcine lower esophageal sphincter. / Holst, J J; Poulsen, Steen Seier.

In: Digestion, Vol. 42, No. 3, 1989, p. 151-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Holst, JJ & Poulsen, SS 1989, 'Occurrence, distribution and motor effects of galanin in the porcine lower esophageal sphincter', Digestion, vol. 42, no. 3, pp. 151-7.

APA

Holst, J. J., & Poulsen, S. S. (1989). Occurrence, distribution and motor effects of galanin in the porcine lower esophageal sphincter. Digestion, 42(3), 151-7.

Vancouver

Holst JJ, Poulsen SS. Occurrence, distribution and motor effects of galanin in the porcine lower esophageal sphincter. Digestion. 1989;42(3):151-7.

Author

Holst, J J ; Poulsen, Steen Seier. / Occurrence, distribution and motor effects of galanin in the porcine lower esophageal sphincter. In: Digestion. 1989 ; Vol. 42, No. 3. pp. 151-7.

Bibtex

@article{60f20831c7414e5f941c14db8daeca6a,
title = "Occurrence, distribution and motor effects of galanin in the porcine lower esophageal sphincter",
abstract = "Specimens from the lower esophageal sphincter (LES) region of the pig were analyzed for galanin-like immunoreactivity (GAL-LI) using radioimmunoassay and immunohistochemistry. The mean concentration of GAL-LI was 3.4 pmol/g tissue. GAL-LI nerve fibers were observed surrounding muscle bundles in the smooth circular muscle layer, and in ganglion cells of the myenteric plexus. Bolus injection of 40-200 pmol/kg of galanin directly into the arterial supply of the resting LES increased the LES pressure (LESP) dose-dependently, whereas slow infusion of 2-100 pmol galanin/kg/min had no effect on resting LESP. The vagally increased LESP was not modulated by simultaneous galanin infusion, and the concentration of galanin in the venous effluent of the LES declined insignificantly during vagal stimulation. It is concluded that galanin may be an important neuropeptide for the modulation of resting LES tone.",
keywords = "Animals, Electric Stimulation, Esophagus, Galanin, Immunohistochemistry, Movement, Neuropeptides, Osmolar Concentration, Peptides, Swine, Tissue Distribution, Vagus Nerve",
author = "Holst, {J J} and Poulsen, {Steen Seier}",
year = "1989",
language = "English",
volume = "42",
pages = "151--7",
journal = "Digestion",
issn = "0012-2823",
publisher = "S Karger AG",
number = "3",

}

RIS

TY - JOUR

T1 - Occurrence, distribution and motor effects of galanin in the porcine lower esophageal sphincter

AU - Holst, J J

AU - Poulsen, Steen Seier

PY - 1989

Y1 - 1989

N2 - Specimens from the lower esophageal sphincter (LES) region of the pig were analyzed for galanin-like immunoreactivity (GAL-LI) using radioimmunoassay and immunohistochemistry. The mean concentration of GAL-LI was 3.4 pmol/g tissue. GAL-LI nerve fibers were observed surrounding muscle bundles in the smooth circular muscle layer, and in ganglion cells of the myenteric plexus. Bolus injection of 40-200 pmol/kg of galanin directly into the arterial supply of the resting LES increased the LES pressure (LESP) dose-dependently, whereas slow infusion of 2-100 pmol galanin/kg/min had no effect on resting LESP. The vagally increased LESP was not modulated by simultaneous galanin infusion, and the concentration of galanin in the venous effluent of the LES declined insignificantly during vagal stimulation. It is concluded that galanin may be an important neuropeptide for the modulation of resting LES tone.

AB - Specimens from the lower esophageal sphincter (LES) region of the pig were analyzed for galanin-like immunoreactivity (GAL-LI) using radioimmunoassay and immunohistochemistry. The mean concentration of GAL-LI was 3.4 pmol/g tissue. GAL-LI nerve fibers were observed surrounding muscle bundles in the smooth circular muscle layer, and in ganglion cells of the myenteric plexus. Bolus injection of 40-200 pmol/kg of galanin directly into the arterial supply of the resting LES increased the LES pressure (LESP) dose-dependently, whereas slow infusion of 2-100 pmol galanin/kg/min had no effect on resting LESP. The vagally increased LESP was not modulated by simultaneous galanin infusion, and the concentration of galanin in the venous effluent of the LES declined insignificantly during vagal stimulation. It is concluded that galanin may be an important neuropeptide for the modulation of resting LES tone.

KW - Animals

KW - Electric Stimulation

KW - Esophagus

KW - Galanin

KW - Immunohistochemistry

KW - Movement

KW - Neuropeptides

KW - Osmolar Concentration

KW - Peptides

KW - Swine

KW - Tissue Distribution

KW - Vagus Nerve

M3 - Journal article

C2 - 2475382

VL - 42

SP - 151

EP - 157

JO - Digestion

JF - Digestion

SN - 0012-2823

IS - 3

ER -

ID: 47488259