Normal values and reference ranges for left atrial strain by speckle-tracking echocardiography: the Copenhagen City Heart Study
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Normal values and reference ranges for left atrial strain by speckle-tracking echocardiography : the Copenhagen City Heart Study. / Nielsen, Anne Bjerg; Skaarup, Kristoffer Grundtvig; Hauser, Raphael; Johansen, Niklas Dyrby; Lassen, Mats Christian Højbjerg; Jensen, Gorm Boje; Schnohr, Peter; Møgelvang, Rasmus; Biering-Sørensen, Tor.
In: European Heart Journal Cardiovascular Imaging, Vol. 23, No. 1, 2022, p. 42-51.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Normal values and reference ranges for left atrial strain by speckle-tracking echocardiography
T2 - the Copenhagen City Heart Study
AU - Nielsen, Anne Bjerg
AU - Skaarup, Kristoffer Grundtvig
AU - Hauser, Raphael
AU - Johansen, Niklas Dyrby
AU - Lassen, Mats Christian Højbjerg
AU - Jensen, Gorm Boje
AU - Schnohr, Peter
AU - Møgelvang, Rasmus
AU - Biering-Sørensen, Tor
N1 - Publisher Copyright: © The Author(s) 2021.
PY - 2022
Y1 - 2022
N2 - Aims: Left atrial (LA) function assessed by two-dimensional speckle-tracking echocardiography has shown increasing clinical and prognostic significance. We sought to establish age- and sex-based normative values of LA strain in the general population and to assess the prognostic yield of lower limits of normality of LA strain in relation to future atrial fibrillation (AF). Methods and results: We determined normative values of peak atrial longitudinal strain (PALS), peak atrial contraction strain (PACS), and LA strain during the conduit phase (LACS) in 1641 healthy participants included in the fifth Copenhagen City Heart Study. In a secondary analysis, a validation cohort of 2016 participants, regardless of health status, were included to assess the prognostic value of the established reference values. In the healthy cohort, median age was 46 years (interquartile range 32-57), 62% were female. Median PALS, PACS, and LACS and corresponding limits of normality in the healthy participants were 39.4% (23.0-67.6%), 15.5% (6.4-28.0%), and 23.7% (8.8-44.8%), respectively. There was a tendency of lower values of PALS and LACS in males and older participants, while PACS tended to increase with advancing age. The established lower limits of normality showed high specificity (range 93-94%) regarding future AF, implying a low risk of developing AF in participants with LA strain above the lower limits of normality in their respective sex and age group. Conclusion: We report normal values for LA strain stratified by sex and age. The lower limits of normality showed high specificity regarding future AF.
AB - Aims: Left atrial (LA) function assessed by two-dimensional speckle-tracking echocardiography has shown increasing clinical and prognostic significance. We sought to establish age- and sex-based normative values of LA strain in the general population and to assess the prognostic yield of lower limits of normality of LA strain in relation to future atrial fibrillation (AF). Methods and results: We determined normative values of peak atrial longitudinal strain (PALS), peak atrial contraction strain (PACS), and LA strain during the conduit phase (LACS) in 1641 healthy participants included in the fifth Copenhagen City Heart Study. In a secondary analysis, a validation cohort of 2016 participants, regardless of health status, were included to assess the prognostic value of the established reference values. In the healthy cohort, median age was 46 years (interquartile range 32-57), 62% were female. Median PALS, PACS, and LACS and corresponding limits of normality in the healthy participants were 39.4% (23.0-67.6%), 15.5% (6.4-28.0%), and 23.7% (8.8-44.8%), respectively. There was a tendency of lower values of PALS and LACS in males and older participants, while PACS tended to increase with advancing age. The established lower limits of normality showed high specificity (range 93-94%) regarding future AF, implying a low risk of developing AF in participants with LA strain above the lower limits of normality in their respective sex and age group. Conclusion: We report normal values for LA strain stratified by sex and age. The lower limits of normality showed high specificity regarding future AF.
KW - 2D speckle-tracking echocardiography
KW - atrial fibrillation
KW - general population
KW - left atrial function
KW - left atrial strain
KW - normative values
U2 - 10.1093/ehjci/jeab201
DO - 10.1093/ehjci/jeab201
M3 - Journal article
C2 - 34632487
AN - SCOPUS:85121672558
VL - 23
SP - 42
EP - 51
JO - European Heart Journal Cardiovascular Imaging
JF - European Heart Journal Cardiovascular Imaging
SN - 2047-2404
IS - 1
ER -
ID: 302815468