No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course. / Mikkelsen, Kristian H.; Vilsboll, Tina; Holst, Jens J.; Hartmann, Bolette; Knop, Filip K.; Frost, Morten.

In: BMC Endocrine Disorders, Vol. 18, 60, 2018.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Mikkelsen, KH, Vilsboll, T, Holst, JJ, Hartmann, B, Knop, FK & Frost, M 2018, 'No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course', BMC Endocrine Disorders, vol. 18, 60. https://doi.org/10.1186/s12902-018-0291-x

APA

Mikkelsen, K. H., Vilsboll, T., Holst, J. J., Hartmann, B., Knop, F. K., & Frost, M. (2018). No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course. BMC Endocrine Disorders, 18, [60]. https://doi.org/10.1186/s12902-018-0291-x

Vancouver

Mikkelsen KH, Vilsboll T, Holst JJ, Hartmann B, Knop FK, Frost M. No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course. BMC Endocrine Disorders. 2018;18. 60. https://doi.org/10.1186/s12902-018-0291-x

Author

Mikkelsen, Kristian H. ; Vilsboll, Tina ; Holst, Jens J. ; Hartmann, Bolette ; Knop, Filip K. ; Frost, Morten. / No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course. In: BMC Endocrine Disorders. 2018 ; Vol. 18.

Bibtex

@article{c709aef7ba01424e822782258436014e,
title = "No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course",
abstract = "Background: Intestinal bacteria influence bone remodeling in rodents, and antibiotic manipulation of the rodent gut microbiota increases bone formation and prevents ovariectomy-induced bone loss. In theory, these effects may be mediated by changes in sex hormone biotransformation in the gut, gut serotonin secretion or nutrition-induced secretion of glucagon-like peptide 2 (GLP-2) and glucose-dependent insulinotropic hormone (GIP). Antibiotics change the human gut microbiota, but the effect of antibiotic treatment on human bone turnover is unknown. Methods: We analyzed serum levels of bone turnover markers, serotonin, GLP-2 and sex hormones before, immediately after, and eight, 42 and 180 days after a 4-day per oral antibiotic cocktail (vancomycin 500 mg, gentamycin 40 mg and meropenem 500 mg once-daily) in twelve healthy adult males. Fasting and meal-stimulated procollagen type I amino-terminal propeptide (P1NP), C-telopeptide of type I collagen (CTX) and osteocalcin levels were measured. Results: While the antibiotic course reduced the stool abundance and composition of anaerobic bacteria as confirmed by cultivation studies, neither short nor long-term alterations in serum P1NP, CTX and osteocalcin were observed. Furthermore, we did not observe any changes in levels of serum GLP-2, serotonin or sex hormones. Conclusion: Eradication of anaerobic bacteria from healthy adult males had no effect on serum bone turnover markers.",
author = "Mikkelsen, {Kristian H.} and Tina Vilsboll and Holst, {Jens J.} and Bolette Hartmann and Knop, {Filip K.} and Morten Frost",
year = "2018",
doi = "10.1186/s12902-018-0291-x",
language = "English",
volume = "18",
journal = "B M C Endocrine Disorders",
issn = "1472-6823",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - No changes in levels of bone formation and resorption markers following a broad-spectrum antibiotic course

AU - Mikkelsen, Kristian H.

AU - Vilsboll, Tina

AU - Holst, Jens J.

AU - Hartmann, Bolette

AU - Knop, Filip K.

AU - Frost, Morten

PY - 2018

Y1 - 2018

N2 - Background: Intestinal bacteria influence bone remodeling in rodents, and antibiotic manipulation of the rodent gut microbiota increases bone formation and prevents ovariectomy-induced bone loss. In theory, these effects may be mediated by changes in sex hormone biotransformation in the gut, gut serotonin secretion or nutrition-induced secretion of glucagon-like peptide 2 (GLP-2) and glucose-dependent insulinotropic hormone (GIP). Antibiotics change the human gut microbiota, but the effect of antibiotic treatment on human bone turnover is unknown. Methods: We analyzed serum levels of bone turnover markers, serotonin, GLP-2 and sex hormones before, immediately after, and eight, 42 and 180 days after a 4-day per oral antibiotic cocktail (vancomycin 500 mg, gentamycin 40 mg and meropenem 500 mg once-daily) in twelve healthy adult males. Fasting and meal-stimulated procollagen type I amino-terminal propeptide (P1NP), C-telopeptide of type I collagen (CTX) and osteocalcin levels were measured. Results: While the antibiotic course reduced the stool abundance and composition of anaerobic bacteria as confirmed by cultivation studies, neither short nor long-term alterations in serum P1NP, CTX and osteocalcin were observed. Furthermore, we did not observe any changes in levels of serum GLP-2, serotonin or sex hormones. Conclusion: Eradication of anaerobic bacteria from healthy adult males had no effect on serum bone turnover markers.

AB - Background: Intestinal bacteria influence bone remodeling in rodents, and antibiotic manipulation of the rodent gut microbiota increases bone formation and prevents ovariectomy-induced bone loss. In theory, these effects may be mediated by changes in sex hormone biotransformation in the gut, gut serotonin secretion or nutrition-induced secretion of glucagon-like peptide 2 (GLP-2) and glucose-dependent insulinotropic hormone (GIP). Antibiotics change the human gut microbiota, but the effect of antibiotic treatment on human bone turnover is unknown. Methods: We analyzed serum levels of bone turnover markers, serotonin, GLP-2 and sex hormones before, immediately after, and eight, 42 and 180 days after a 4-day per oral antibiotic cocktail (vancomycin 500 mg, gentamycin 40 mg and meropenem 500 mg once-daily) in twelve healthy adult males. Fasting and meal-stimulated procollagen type I amino-terminal propeptide (P1NP), C-telopeptide of type I collagen (CTX) and osteocalcin levels were measured. Results: While the antibiotic course reduced the stool abundance and composition of anaerobic bacteria as confirmed by cultivation studies, neither short nor long-term alterations in serum P1NP, CTX and osteocalcin were observed. Furthermore, we did not observe any changes in levels of serum GLP-2, serotonin or sex hormones. Conclusion: Eradication of anaerobic bacteria from healthy adult males had no effect on serum bone turnover markers.

U2 - 10.1186/s12902-018-0291-x

DO - 10.1186/s12902-018-0291-x

M3 - Journal article

C2 - 30180841

VL - 18

JO - B M C Endocrine Disorders

JF - B M C Endocrine Disorders

SN - 1472-6823

M1 - 60

ER -

ID: 212423277