TY - JOUR

T1 - Neuroendokrin aktivering ved hjerteinsufficiens I

T2 - Patofysiologi og farmakologisk intervention

AU - Kjaer, A.

PY - 2000/10/30

Y1 - 2000/10/30

N2 - The important neuroendocrine systems implicated in heart failure are reviewed here, with special emphasis on their possible role in path pathophysiology and the chances of pharmacological intervention. The part played by the sympathetic nervous system and the renin-angiotensin-aldosterone system and the beneficial effects of β-blockers, ACE inhibitors, and angiotensin II antagonists are well-established. The involvement of vasopressin, endothelin-1, ANP, BNP, and TNF-α and the interventional possibilities relating to these hormones are also discussed. It is concluded that, in addition to the known interventional principles of neuroendocrine activation, there is a series of new exciting principles and some of them might become important in the future.

AB - The important neuroendocrine systems implicated in heart failure are reviewed here, with special emphasis on their possible role in path pathophysiology and the chances of pharmacological intervention. The part played by the sympathetic nervous system and the renin-angiotensin-aldosterone system and the beneficial effects of β-blockers, ACE inhibitors, and angiotensin II antagonists are well-established. The involvement of vasopressin, endothelin-1, ANP, BNP, and TNF-α and the interventional possibilities relating to these hormones are also discussed. It is concluded that, in addition to the known interventional principles of neuroendocrine activation, there is a series of new exciting principles and some of them might become important in the future.

UR - http://www.scopus.com/inward/record.url?scp=0034735419&partnerID=8YFLogxK

M3 - Review

C2 - 11094549

AN - SCOPUS:0034735419

VL - 162

SP - 5905

EP - 5909

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 44

ER -