TY - JOUR

T1 - Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid

AU - Malle, Ernst

AU - Marsche, Gunther

AU - Arnhold, Jürgen

AU - Davies, Michael Jonathan

PY - 2006/4

Y1 - 2006/4

N2 - Substantial evidence supports the notion that oxidative processes contribute to the pathogenesis of atherosclerosis and coronary heart disease. The nature of the oxidants that give rise to the elevated levels of oxidised lipids and proteins, and decreased levels of antioxidants, detected in human atherosclerotic lesions are, however, unclear, with multiple species having been invoked. Over the last few years, considerable data have been obtained in support of the hypothesis that oxidants generated by the heme enzyme myeloperoxidase play a key role in oxidation reactions in the artery wall. In this article, the evidence for a role of myeloperoxidase, and oxidants generated therefrom, in the modification of low-density lipoprotein, the major source of lipids in atherosclerotic lesions, is reviewed. Particular emphasis is placed on the reactions of the reactive species generated by this enzyme, the mechanisms and sites of damage, the role of modification of the different components of low-density lipoprotein, and the biological consequences of such oxidation on cell types present in the artery wall and in the circulation, respectively.

AB - Substantial evidence supports the notion that oxidative processes contribute to the pathogenesis of atherosclerosis and coronary heart disease. The nature of the oxidants that give rise to the elevated levels of oxidised lipids and proteins, and decreased levels of antioxidants, detected in human atherosclerotic lesions are, however, unclear, with multiple species having been invoked. Over the last few years, considerable data have been obtained in support of the hypothesis that oxidants generated by the heme enzyme myeloperoxidase play a key role in oxidation reactions in the artery wall. In this article, the evidence for a role of myeloperoxidase, and oxidants generated therefrom, in the modification of low-density lipoprotein, the major source of lipids in atherosclerotic lesions, is reviewed. Particular emphasis is placed on the reactions of the reactive species generated by this enzyme, the mechanisms and sites of damage, the role of modification of the different components of low-density lipoprotein, and the biological consequences of such oxidation on cell types present in the artery wall and in the circulation, respectively.

KW - Animals

KW - Apolipoprotein B-100

KW - Apolipoproteins B

KW - Atherosclerosis

KW - Humans

KW - Hypochlorous Acid

KW - Lipid Peroxidation

KW - Lipoproteins, LDL

KW - Oxidants

KW - Oxidation-Reduction

KW - Peroxidase

U2 - 10.1016/j.bbalip.2006.03.024

DO - 10.1016/j.bbalip.2006.03.024

M3 - Journal article

C2 - 16698314

VL - 1761

SP - 392

EP - 415

JO - Biochimica et Biophysica Acta - Reviews on Cancer

JF - Biochimica et Biophysica Acta - Reviews on Cancer

SN - 0304-419X

IS - 4

ER -