Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration
Research output: Contribution to journal › Journal article › peer-review
The glucose-lowering drug metformin has been shown to inhibit complex I of the mitochondrial electron transport chain in skeletal muscle. To investigate this effect in vivo we studied skeletal muscle mitochondrial respiratory capacity and content from patients with type 2 diabetes treated with metformin (n = 14) or sulfonylurea (n = 8) and healthy control (n = 18) participants.
Original language | English |
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Journal | Diabetologia |
Volume | 55 |
Issue number | 2 |
Pages (from-to) | 443-9 |
Number of pages | 7 |
ISSN | 0012-186X |
DOIs | |
Publication status | Published - 2012 |
- Blood Glucose, Body Mass Index, Case-Control Studies, Cell Respiration, Citrate (si)-Synthase, Diabetes Mellitus, Type 2, Electron Transport Complex I, Hemoglobin A, Glycosylated, Humans, Hypoglycemic Agents, Insulin, Male, Metformin, Middle Aged, Models, Biological, Muscle, Skeletal, Oxygen Consumption, Sulfonylurea Compounds
Research areas
ID: 40176660