Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. / Manville, Rían W.; Baldwin, Samuel N.; Eriksen, Emil Ørnberg; Jepps, Thomas A.; Abbott, Geoffrey W.

In: FASEB Journal, Vol. 37, No. 9, e23125, 2023, p. 1-15.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Manville, RW, Baldwin, SN, Eriksen, EØ, Jepps, TA & Abbott, GW 2023, 'Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels', FASEB Journal, vol. 37, no. 9, e23125, pp. 1-15. https://doi.org/10.1096/fj.202301132R

APA

Manville, R. W., Baldwin, S. N., Eriksen, E. Ø., Jepps, T. A., & Abbott, G. W. (2023). Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. FASEB Journal, 37(9), 1-15. [e23125]. https://doi.org/10.1096/fj.202301132R

Vancouver

Manville RW, Baldwin SN, Eriksen EØ, Jepps TA, Abbott GW. Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. FASEB Journal. 2023;37(9):1-15. e23125. https://doi.org/10.1096/fj.202301132R

Author

Manville, Rían W. ; Baldwin, Samuel N. ; Eriksen, Emil Ørnberg ; Jepps, Thomas A. ; Abbott, Geoffrey W. / Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels. In: FASEB Journal. 2023 ; Vol. 37, No. 9. pp. 1-15.

Bibtex

@article{cb2fd3fec6f847ff9ef367dc086de5f1,
title = "Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels",
abstract = "The evergreen plant rosemary (Salvia rosmarinus) has been employed medicinally for centuries as a memory aid, analgesic, spasmolytic, vasorelaxant and antihypertensive, with recent preclinical and clinical evidence rationalizing some applications. Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) subfamily are highly influential in the nervous system, muscle and epithelia. KCNQ4 and KCNQ5 regulate vascular smooth muscle excitability and contractility and are implicated as antihypertensive drug targets. Here, we found that rosemary extract potentiates homomeric and heteromeric KCNQ4 and KCNQ5 activity, resulting in membrane hyperpolarization. Two rosemary diterpenes, carnosol and carnosic acid, underlie the effects and, like rosemary, are efficacious KCNQ-dependent vasorelaxants, quantified by myography in rat mesenteric arteries. Sex- and estrous cycle stage-dependence of the vasorelaxation matches sex- and estrous cycle stage-dependent KCNQ expression. The results uncover a molecular mechanism underlying rosemary vasorelaxant effects and identify new chemical spaces for KCNQ-dependent vasorelaxants.",
keywords = "herbal medicine, KCNQ4, KCNQ5, Salvia rosmarinus, vasorelaxant",
author = "Manville, {R{\'i}an W.} and Baldwin, {Samuel N.} and Eriksen, {Emil {\O}rnberg} and Jepps, {Thomas A.} and Abbott, {Geoffrey W.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.",
year = "2023",
doi = "10.1096/fj.202301132R",
language = "English",
volume = "37",
pages = "1--15",
journal = "F A S E B Journal",
issn = "0892-6638",
publisher = "Federation of American Societies for Experimental Biology",
number = "9",

}

RIS

TY - JOUR

T1 - Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels

AU - Manville, Rían W.

AU - Baldwin, Samuel N.

AU - Eriksen, Emil Ørnberg

AU - Jepps, Thomas A.

AU - Abbott, Geoffrey W.

N1 - Publisher Copyright: © 2023 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.

PY - 2023

Y1 - 2023

N2 - The evergreen plant rosemary (Salvia rosmarinus) has been employed medicinally for centuries as a memory aid, analgesic, spasmolytic, vasorelaxant and antihypertensive, with recent preclinical and clinical evidence rationalizing some applications. Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) subfamily are highly influential in the nervous system, muscle and epithelia. KCNQ4 and KCNQ5 regulate vascular smooth muscle excitability and contractility and are implicated as antihypertensive drug targets. Here, we found that rosemary extract potentiates homomeric and heteromeric KCNQ4 and KCNQ5 activity, resulting in membrane hyperpolarization. Two rosemary diterpenes, carnosol and carnosic acid, underlie the effects and, like rosemary, are efficacious KCNQ-dependent vasorelaxants, quantified by myography in rat mesenteric arteries. Sex- and estrous cycle stage-dependence of the vasorelaxation matches sex- and estrous cycle stage-dependent KCNQ expression. The results uncover a molecular mechanism underlying rosemary vasorelaxant effects and identify new chemical spaces for KCNQ-dependent vasorelaxants.

AB - The evergreen plant rosemary (Salvia rosmarinus) has been employed medicinally for centuries as a memory aid, analgesic, spasmolytic, vasorelaxant and antihypertensive, with recent preclinical and clinical evidence rationalizing some applications. Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) subfamily are highly influential in the nervous system, muscle and epithelia. KCNQ4 and KCNQ5 regulate vascular smooth muscle excitability and contractility and are implicated as antihypertensive drug targets. Here, we found that rosemary extract potentiates homomeric and heteromeric KCNQ4 and KCNQ5 activity, resulting in membrane hyperpolarization. Two rosemary diterpenes, carnosol and carnosic acid, underlie the effects and, like rosemary, are efficacious KCNQ-dependent vasorelaxants, quantified by myography in rat mesenteric arteries. Sex- and estrous cycle stage-dependence of the vasorelaxation matches sex- and estrous cycle stage-dependent KCNQ expression. The results uncover a molecular mechanism underlying rosemary vasorelaxant effects and identify new chemical spaces for KCNQ-dependent vasorelaxants.

KW - herbal medicine

KW - KCNQ4

KW - KCNQ5

KW - Salvia rosmarinus

KW - vasorelaxant

UR - http://www.scopus.com/inward/record.url?scp=85166429859&partnerID=8YFLogxK

U2 - 10.1096/fj.202301132R

DO - 10.1096/fj.202301132R

M3 - Journal article

C2 - 37535015

AN - SCOPUS:85166429859

VL - 37

SP - 1

EP - 15

JO - F A S E B Journal

JF - F A S E B Journal

SN - 0892-6638

IS - 9

M1 - e23125

ER -

ID: 362058543