Mechanics and dynamics of triglyceride-phospholipid model membranes: Implications for cellular properties and function

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Mechanics and dynamics of triglyceride-phospholipid model membranes : Implications for cellular properties and function. / Pakkanen, Kirsi I.; Duelund, Lars; Qvortrup, Klaus; Ipsen, John Hjorth.

In: BBA General Subjects, Vol. 1808, No. 8, 08.2011, p. 1947-56.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pakkanen, KI, Duelund, L, Qvortrup, K & Ipsen, JH 2011, 'Mechanics and dynamics of triglyceride-phospholipid model membranes: Implications for cellular properties and function', BBA General Subjects, vol. 1808, no. 8, pp. 1947-56. https://doi.org/10.1016/j.bbamem.2011.04.006

APA

Pakkanen, K. I., Duelund, L., Qvortrup, K., & Ipsen, J. H. (2011). Mechanics and dynamics of triglyceride-phospholipid model membranes: Implications for cellular properties and function. BBA General Subjects, 1808(8), 1947-56. https://doi.org/10.1016/j.bbamem.2011.04.006

Vancouver

Pakkanen KI, Duelund L, Qvortrup K, Ipsen JH. Mechanics and dynamics of triglyceride-phospholipid model membranes: Implications for cellular properties and function. BBA General Subjects. 2011 Aug;1808(8):1947-56. https://doi.org/10.1016/j.bbamem.2011.04.006

Author

Pakkanen, Kirsi I. ; Duelund, Lars ; Qvortrup, Klaus ; Ipsen, John Hjorth. / Mechanics and dynamics of triglyceride-phospholipid model membranes : Implications for cellular properties and function. In: BBA General Subjects. 2011 ; Vol. 1808, No. 8. pp. 1947-56.

Bibtex

@article{4b9eb77208134dd9aad4d53e374873d8,
title = "Mechanics and dynamics of triglyceride-phospholipid model membranes: Implications for cellular properties and function",
abstract = "We demonstrate here that triolein alters the mechanical properties of phospholipid membranes and induces extraordinary conformational dynamics. Triolein containing membranes exhibit fluctuations up to size range of 100µm and with the help of these are e.g. able to squeeze through narrow passages between neighbouring structures. Triolein-phosphatidylcholine membranes were found to have bending rigidity significantly lower than that of corresponding pure phosphatidylcholine membrane. Moreover, the triolein containing membranes were found to be reluctant to fuse, which is in good accordance with larger lamellar distances observed in the TOPOPC membranes. These findings suggest repulsion between adjacent membranes. We provide a comprehensive discussion on the possible explanations for the observed mechanics and dynamics in the TOPOPC system and on their potential cellular implications.",
keywords = "Calorimetry, Differential Scanning, Cell Membrane, Elasticity, Fluorescence Resonance Energy Transfer, Membrane Fluidity, Membrane Fusion, Membranes, Artificial, Microscopy, Confocal, Microscopy, Electron, Transmission, Microscopy, Phase-Contrast, Molecular Conformation, Phosphatidylcholines, Scattering, Small Angle, Triolein",
author = "Pakkanen, {Kirsi I.} and Lars Duelund and Klaus Qvortrup and Ipsen, {John Hjorth}",
note = "Copyright {\textcopyright} 2011 Elsevier B.V. All rights reserved.",
year = "2011",
month = aug,
doi = "10.1016/j.bbamem.2011.04.006",
language = "English",
volume = "1808",
pages = "1947--56",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - Mechanics and dynamics of triglyceride-phospholipid model membranes

T2 - Implications for cellular properties and function

AU - Pakkanen, Kirsi I.

AU - Duelund, Lars

AU - Qvortrup, Klaus

AU - Ipsen, John Hjorth

N1 - Copyright © 2011 Elsevier B.V. All rights reserved.

PY - 2011/8

Y1 - 2011/8

N2 - We demonstrate here that triolein alters the mechanical properties of phospholipid membranes and induces extraordinary conformational dynamics. Triolein containing membranes exhibit fluctuations up to size range of 100µm and with the help of these are e.g. able to squeeze through narrow passages between neighbouring structures. Triolein-phosphatidylcholine membranes were found to have bending rigidity significantly lower than that of corresponding pure phosphatidylcholine membrane. Moreover, the triolein containing membranes were found to be reluctant to fuse, which is in good accordance with larger lamellar distances observed in the TOPOPC membranes. These findings suggest repulsion between adjacent membranes. We provide a comprehensive discussion on the possible explanations for the observed mechanics and dynamics in the TOPOPC system and on their potential cellular implications.

AB - We demonstrate here that triolein alters the mechanical properties of phospholipid membranes and induces extraordinary conformational dynamics. Triolein containing membranes exhibit fluctuations up to size range of 100µm and with the help of these are e.g. able to squeeze through narrow passages between neighbouring structures. Triolein-phosphatidylcholine membranes were found to have bending rigidity significantly lower than that of corresponding pure phosphatidylcholine membrane. Moreover, the triolein containing membranes were found to be reluctant to fuse, which is in good accordance with larger lamellar distances observed in the TOPOPC membranes. These findings suggest repulsion between adjacent membranes. We provide a comprehensive discussion on the possible explanations for the observed mechanics and dynamics in the TOPOPC system and on their potential cellular implications.

KW - Calorimetry, Differential Scanning

KW - Cell Membrane

KW - Elasticity

KW - Fluorescence Resonance Energy Transfer

KW - Membrane Fluidity

KW - Membrane Fusion

KW - Membranes, Artificial

KW - Microscopy, Confocal

KW - Microscopy, Electron, Transmission

KW - Microscopy, Phase-Contrast

KW - Molecular Conformation

KW - Phosphatidylcholines

KW - Scattering, Small Angle

KW - Triolein

U2 - 10.1016/j.bbamem.2011.04.006

DO - 10.1016/j.bbamem.2011.04.006

M3 - Journal article

C2 - 21545789

VL - 1808

SP - 1947

EP - 1956

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 8

ER -

ID: 38185999