Managing the complexity of communication: regulation of gap junctions by post-translational modification

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Managing the complexity of communication: regulation of gap junctions by post-translational modification. / Axelsen, Lene Nygaard; Callø, Kirstine; von Holstein-Rathlou, Niels-Henrik; Nielsen, Morten S.

In: Frontiers in Pharmacology, Vol. 4, 130, 10.2013, p. 1-18.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Axelsen, LN, Callø, K, von Holstein-Rathlou, N-H & Nielsen, MS 2013, 'Managing the complexity of communication: regulation of gap junctions by post-translational modification', Frontiers in Pharmacology, vol. 4, 130, pp. 1-18. https://doi.org/10.3389/fphar.2013.00130

APA

Axelsen, L. N., Callø, K., von Holstein-Rathlou, N-H., & Nielsen, M. S. (2013). Managing the complexity of communication: regulation of gap junctions by post-translational modification. Frontiers in Pharmacology, 4, 1-18. [130]. https://doi.org/10.3389/fphar.2013.00130

Vancouver

Axelsen LN, Callø K, von Holstein-Rathlou N-H, Nielsen MS. Managing the complexity of communication: regulation of gap junctions by post-translational modification. Frontiers in Pharmacology. 2013 Oct;4:1-18. 130. https://doi.org/10.3389/fphar.2013.00130

Author

Axelsen, Lene Nygaard ; Callø, Kirstine ; von Holstein-Rathlou, Niels-Henrik ; Nielsen, Morten S. / Managing the complexity of communication: regulation of gap junctions by post-translational modification. In: Frontiers in Pharmacology. 2013 ; Vol. 4. pp. 1-18.

Bibtex

@article{a939fbd57b7f4df684033cf5c63e0ec9,
title = "Managing the complexity of communication: regulation of gap junctions by post-translational modification",
abstract = "Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of connexin protein expression by transcription and translation is of great importance, the trafficking, channel activity and degradation are also under tight control. The function of connexins can be regulated by several post translational modifications, which affect numerous parameters; including number of channels, open probability, single channel conductance or selectivity. The most extensively investigated post translational modifications are phosphorylations, which have been documented in all mammalian connexins. Besides phosphorylations, some connexins are known to be ubiquitinated, SUMOylated, nitrosylated, hydroxylated, acetylated, methylated, and γ-carboxyglutamated. The aim of the present review is to summarize our current knowledge of post translational regulation of the connexin family of proteins.",
author = "Axelsen, {Lene Nygaard} and Kirstine Call{\o} and {von Holstein-Rathlou}, Niels-Henrik and Nielsen, {Morten S}",
year = "2013",
month = "10",
doi = "10.3389/fphar.2013.00130",
language = "English",
volume = "4",
pages = "1--18",
journal = "Frontiers in Pharmacology",
issn = "1663-9812",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Managing the complexity of communication: regulation of gap junctions by post-translational modification

AU - Axelsen, Lene Nygaard

AU - Callø, Kirstine

AU - von Holstein-Rathlou, Niels-Henrik

AU - Nielsen, Morten S

PY - 2013/10

Y1 - 2013/10

N2 - Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of connexin protein expression by transcription and translation is of great importance, the trafficking, channel activity and degradation are also under tight control. The function of connexins can be regulated by several post translational modifications, which affect numerous parameters; including number of channels, open probability, single channel conductance or selectivity. The most extensively investigated post translational modifications are phosphorylations, which have been documented in all mammalian connexins. Besides phosphorylations, some connexins are known to be ubiquitinated, SUMOylated, nitrosylated, hydroxylated, acetylated, methylated, and γ-carboxyglutamated. The aim of the present review is to summarize our current knowledge of post translational regulation of the connexin family of proteins.

AB - Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of connexin protein expression by transcription and translation is of great importance, the trafficking, channel activity and degradation are also under tight control. The function of connexins can be regulated by several post translational modifications, which affect numerous parameters; including number of channels, open probability, single channel conductance or selectivity. The most extensively investigated post translational modifications are phosphorylations, which have been documented in all mammalian connexins. Besides phosphorylations, some connexins are known to be ubiquitinated, SUMOylated, nitrosylated, hydroxylated, acetylated, methylated, and γ-carboxyglutamated. The aim of the present review is to summarize our current knowledge of post translational regulation of the connexin family of proteins.

U2 - 10.3389/fphar.2013.00130

DO - 10.3389/fphar.2013.00130

M3 - Journal article

C2 - 24155720

VL - 4

SP - 1

EP - 18

JO - Frontiers in Pharmacology

JF - Frontiers in Pharmacology

SN - 1663-9812

M1 - 130

ER -

ID: 92092927