Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines. / Lundh, M; Christensen, D P; Rasmussen, D N; Mascagni, P; Dinarello, C A; Billestrup, N; Grunnet, L G; Mandrup-Poulsen, T.

In: Diabetologia, Vol. 53, No. 12, 01.12.2010, p. 2569-78.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lundh, M, Christensen, DP, Rasmussen, DN, Mascagni, P, Dinarello, CA, Billestrup, N, Grunnet, LG & Mandrup-Poulsen, T 2010, 'Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines', Diabetologia, vol. 53, no. 12, pp. 2569-78. https://doi.org/10.1007/s00125-010-1892-8

APA

Lundh, M., Christensen, D. P., Rasmussen, D. N., Mascagni, P., Dinarello, C. A., Billestrup, N., Grunnet, L. G., & Mandrup-Poulsen, T. (2010). Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines. Diabetologia, 53(12), 2569-78. https://doi.org/10.1007/s00125-010-1892-8

Vancouver

Lundh M, Christensen DP, Rasmussen DN, Mascagni P, Dinarello CA, Billestrup N et al. Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines. Diabetologia. 2010 Dec 1;53(12):2569-78. https://doi.org/10.1007/s00125-010-1892-8

Author

Lundh, M ; Christensen, D P ; Rasmussen, D N ; Mascagni, P ; Dinarello, C A ; Billestrup, N ; Grunnet, L G ; Mandrup-Poulsen, T. / Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines. In: Diabetologia. 2010 ; Vol. 53, No. 12. pp. 2569-78.

Bibtex

@article{5cfbf2e75e9a4bc7b3d089a9d2a09a65,
title = "Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines",
abstract = "Cytokine-induced beta cell toxicity is abrogated by non-selective inhibitors of lysine deacetylases (KDACs). The KDAC family consists of 11 members, namely histone deacetylases HDAC1 to HDAC11, but it is not known which KDAC members play a role in cytokine-mediated beta cell death. The aim of the present study was to examine the KDAC gene expression profile of the beta cell and to investigate whether KDAC expression is regulated by cytokines. In addition, the protective effect of the non-selective KDAC inhibitor ITF2357 and interdependent regulation of four selected KDACs were investigated.",
author = "M Lundh and Christensen, {D P} and Rasmussen, {D N} and P Mascagni and Dinarello, {C A} and N Billestrup and Grunnet, {L G} and T Mandrup-Poulsen",
year = "2010",
month = dec,
day = "1",
doi = "10.1007/s00125-010-1892-8",
language = "English",
volume = "53",
pages = "2569--78",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

AU - Lundh, M

AU - Christensen, D P

AU - Rasmussen, D N

AU - Mascagni, P

AU - Dinarello, C A

AU - Billestrup, N

AU - Grunnet, L G

AU - Mandrup-Poulsen, T

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Cytokine-induced beta cell toxicity is abrogated by non-selective inhibitors of lysine deacetylases (KDACs). The KDAC family consists of 11 members, namely histone deacetylases HDAC1 to HDAC11, but it is not known which KDAC members play a role in cytokine-mediated beta cell death. The aim of the present study was to examine the KDAC gene expression profile of the beta cell and to investigate whether KDAC expression is regulated by cytokines. In addition, the protective effect of the non-selective KDAC inhibitor ITF2357 and interdependent regulation of four selected KDACs were investigated.

AB - Cytokine-induced beta cell toxicity is abrogated by non-selective inhibitors of lysine deacetylases (KDACs). The KDAC family consists of 11 members, namely histone deacetylases HDAC1 to HDAC11, but it is not known which KDAC members play a role in cytokine-mediated beta cell death. The aim of the present study was to examine the KDAC gene expression profile of the beta cell and to investigate whether KDAC expression is regulated by cytokines. In addition, the protective effect of the non-selective KDAC inhibitor ITF2357 and interdependent regulation of four selected KDACs were investigated.

U2 - 10.1007/s00125-010-1892-8

DO - 10.1007/s00125-010-1892-8

M3 - Journal article

C2 - 20878317

VL - 53

SP - 2569

EP - 2578

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 12

ER -

ID: 32311947