Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes. / Johansen, M. L.; Schou, M.; Rasmussen, J.; Rossignol, P.; Holm, M. R.; Chabanova, E.; Dela, F.; Faber, J.; Kistorp, C.

In: Diabetes & Metabolism, Vol. 45, No. 5, 2019, p. 429-435.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Johansen, ML, Schou, M, Rasmussen, J, Rossignol, P, Holm, MR, Chabanova, E, Dela, F, Faber, J & Kistorp, C 2019, 'Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes', Diabetes & Metabolism, vol. 45, no. 5, pp. 429-435. https://doi.org/10.1016/j.diabet.2018.11.003

APA

Johansen, M. L., Schou, M., Rasmussen, J., Rossignol, P., Holm, M. R., Chabanova, E., Dela, F., Faber, J., & Kistorp, C. (2019). Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes. Diabetes & Metabolism, 45(5), 429-435. https://doi.org/10.1016/j.diabet.2018.11.003

Vancouver

Johansen ML, Schou M, Rasmussen J, Rossignol P, Holm MR, Chabanova E et al. Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes. Diabetes & Metabolism. 2019;45(5):429-435. https://doi.org/10.1016/j.diabet.2018.11.003

Author

Johansen, M. L. ; Schou, M. ; Rasmussen, J. ; Rossignol, P. ; Holm, M. R. ; Chabanova, E. ; Dela, F. ; Faber, J. ; Kistorp, C. / Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes. In: Diabetes & Metabolism. 2019 ; Vol. 45, No. 5. pp. 429-435.

Bibtex

@article{e2b23b360e9742c1aa54b7d3b6b6d535,
title = "Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes",
abstract = "Aim: Natriuretic peptides (NPs) have emerged as important regulators of lipid metabolism. Reduced levels of NPs are reported in obesity and in patients with type 2 diabetes (T2D). This NP deficiency may affect their ectopic fat distribution and lead to high risk of non-alcoholic fatty liver disease (NAFLD). Methods: In this cross-sectional study, the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and liver fat content was quantified using 1H-magnetic resonance spectroscopy in 120 patients with T2D. Results: NAFLD (defined as liver fat content ≥ 5.6%) was found in 57 (48%) of the T2D patients, who also had significantly lower NT-proBNP (P = 0.002) levels compared with patients without NAFLD, but did not differ as regards the presence of cardiovascular disease (CVD) or in kidney function. After adjusting for potential confounders (age, gender, HbA1c, BMI, HOMA2-IR, CVD, eGFR), the odds ratio for the presence of NAFLD was increased by 2.9 (P = 0.048) for NT-proBNP levels < 45 ng/L. In a multivariable linear regression model, the relationship with NT-proBNP was further analyzed as a continuous variable, and was independently and inversely associated with increasing liver fat content after full adjustment (P = 0.031). Conclusion: Reduced plasma NT-proBNP levels are independently associated with high liver fat content in patients with T2D. The present study suggests that NP deficiency may play a role in the development of NAFLD in T2D.",
keywords = "Natriuretic peptide, Non-alcoholic fatty liver disease, Type 2 diabetes",
author = "Johansen, {M. L.} and M. Schou and J. Rasmussen and P. Rossignol and Holm, {M. R.} and E. Chabanova and F. Dela and J. Faber and C. Kistorp",
year = "2019",
doi = "10.1016/j.diabet.2018.11.003",
language = "English",
volume = "45",
pages = "429--435",
journal = "Diabetes & Metabolism",
issn = "1262-3636",
publisher = "Elsevier Masson",
number = "5",

}

RIS

TY - JOUR

T1 - Low N-terminal pro-brain natriuretic peptide levels are associated with non-alcoholic fatty liver disease in patients with type 2 diabetes

AU - Johansen, M. L.

AU - Schou, M.

AU - Rasmussen, J.

AU - Rossignol, P.

AU - Holm, M. R.

AU - Chabanova, E.

AU - Dela, F.

AU - Faber, J.

AU - Kistorp, C.

PY - 2019

Y1 - 2019

N2 - Aim: Natriuretic peptides (NPs) have emerged as important regulators of lipid metabolism. Reduced levels of NPs are reported in obesity and in patients with type 2 diabetes (T2D). This NP deficiency may affect their ectopic fat distribution and lead to high risk of non-alcoholic fatty liver disease (NAFLD). Methods: In this cross-sectional study, the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and liver fat content was quantified using 1H-magnetic resonance spectroscopy in 120 patients with T2D. Results: NAFLD (defined as liver fat content ≥ 5.6%) was found in 57 (48%) of the T2D patients, who also had significantly lower NT-proBNP (P = 0.002) levels compared with patients without NAFLD, but did not differ as regards the presence of cardiovascular disease (CVD) or in kidney function. After adjusting for potential confounders (age, gender, HbA1c, BMI, HOMA2-IR, CVD, eGFR), the odds ratio for the presence of NAFLD was increased by 2.9 (P = 0.048) for NT-proBNP levels < 45 ng/L. In a multivariable linear regression model, the relationship with NT-proBNP was further analyzed as a continuous variable, and was independently and inversely associated with increasing liver fat content after full adjustment (P = 0.031). Conclusion: Reduced plasma NT-proBNP levels are independently associated with high liver fat content in patients with T2D. The present study suggests that NP deficiency may play a role in the development of NAFLD in T2D.

AB - Aim: Natriuretic peptides (NPs) have emerged as important regulators of lipid metabolism. Reduced levels of NPs are reported in obesity and in patients with type 2 diabetes (T2D). This NP deficiency may affect their ectopic fat distribution and lead to high risk of non-alcoholic fatty liver disease (NAFLD). Methods: In this cross-sectional study, the association between N-terminal pro-B-type natriuretic peptide (NT-proBNP) and liver fat content was quantified using 1H-magnetic resonance spectroscopy in 120 patients with T2D. Results: NAFLD (defined as liver fat content ≥ 5.6%) was found in 57 (48%) of the T2D patients, who also had significantly lower NT-proBNP (P = 0.002) levels compared with patients without NAFLD, but did not differ as regards the presence of cardiovascular disease (CVD) or in kidney function. After adjusting for potential confounders (age, gender, HbA1c, BMI, HOMA2-IR, CVD, eGFR), the odds ratio for the presence of NAFLD was increased by 2.9 (P = 0.048) for NT-proBNP levels < 45 ng/L. In a multivariable linear regression model, the relationship with NT-proBNP was further analyzed as a continuous variable, and was independently and inversely associated with increasing liver fat content after full adjustment (P = 0.031). Conclusion: Reduced plasma NT-proBNP levels are independently associated with high liver fat content in patients with T2D. The present study suggests that NP deficiency may play a role in the development of NAFLD in T2D.

KW - Natriuretic peptide

KW - Non-alcoholic fatty liver disease

KW - Type 2 diabetes

U2 - 10.1016/j.diabet.2018.11.003

DO - 10.1016/j.diabet.2018.11.003

M3 - Journal article

C2 - 30472196

AN - SCOPUS:85057412168

VL - 45

SP - 429

EP - 435

JO - Diabetes & Metabolism

JF - Diabetes & Metabolism

SN - 1262-3636

IS - 5

ER -

ID: 220845483